gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Vahedi K et al. A 3-month double-blind randomised study comparing an olive oil- with a soyabean oil-based intravenous lipid emulsion in home parenteral nutrition patients. 2005 Br. J. Nutr. pmid:16351767
Oikawa D et al. Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice. 2005 Br. J. Nutr. pmid:16115363
Huang YS et al. Effects of repeated gestation and lactation on milk n-6 fatty acid composition in rats fed on a diet rich in 18:2n-6 or 18:3n-6. 1992 Br. J. Nutr. pmid:1445816
Arab K et al. Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. 2006 Br. J. Nutr. pmid:17092368
Dodge JA et al. Paradoxical effects of essential fatty acid supplementation on lipid profiles and sweat electrolytes in cystic fibrosis. 1990 Br. J. Nutr. pmid:2185826
Kirstein D et al. Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes. 1983 Br. J. Nutr. pmid:6315055
De Spirt S et al. Intervention with flaxseed and borage oil supplements modulates skin condition in women. 2009 Br. J. Nutr. pmid:18761778
Javadi M et al. The effect of six different C18 fatty acids on body fat and energy metabolism in mice. 2004 Br. J. Nutr. pmid:15469642
Miles EA et al. The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. 2004 Br. J. Nutr. pmid:15182393
Safarinejad MR et al. Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. 2013 Br. J. Nutr. pmid:23199523
Wright S and Bolton C Breast milk fatty acids in mothers of children with atopic eczema. 1989 Br. J. Nutr. pmid:2557889
Harbige LS et al. Prevention of experimental autoimmune encephalomyelitis in Lewis rats by a novel fungal source of gamma-linolenic acid. 1995 Br. J. Nutr. pmid:8541276
Leigh-Firbank EC et al. Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. 2002 Br. J. Nutr. pmid:12010583
Geppert J et al. Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations. 2008 Br. J. Nutr. pmid:17678567
Rühl R et al. Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution. 2008 Br. J. Nutr. pmid:18005485
Lockett MJ and Tomlinson DR The effects of dietary treatment with essential fatty acids on sciatic nerve conduction and activity of the Na+/K+ pump in streptozotocin-diabetic rats. 1992 Br. J. Pharmacol. pmid:1313726
Cameron NE et al. The effects of evening primrose oil on nerve function and capillarization in streptozotocin-diabetic rats: modulation by the cyclo-oxygenase inhibitor flurbiprofen. 1993 Br. J. Pharmacol. pmid:8401950
Omawari N et al. Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L-NAME, L-arginine, sodium nitroprusside and evening primrose oil. 1996 Br. J. Pharmacol. pmid:8733594
Veale DJ et al. A double-blind placebo controlled trial of Efamol Marine on skin and joint symptoms of psoriatic arthritis. 1994 Br. J. Rheumatol. pmid:7921757
Leventhal LJ et al. Treatment of rheumatoid arthritis with blackcurrant seed oil. 1994 Br. J. Rheumatol. pmid:8081671
Brzeski M et al. Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs. 1991 Br. J. Rheumatol. pmid:1913008
Gateley CA and Mansel RE Management of the painful and nodular breast. 1991 Br. Med. Bull. pmid:1834299
Cerolini S et al. Dietary fish and evening primrose oil with vitamin E effects on semen variables in cockerels. 2005 Br. Poult. Sci. pmid:15957443
Murai A et al. Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail. 1995 Br. Poult. Sci. pmid:8746984
Bíró K et al. Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats. 1997 Brain Res. Bull. pmid:9323440
Hornych A et al. The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects. 2002 Bratisl Lek Listy pmid:12190041
Crowe DL and Chandraratna RA A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. 2004 Breast Cancer Res. pmid:15318936
Menéndez JA et al. Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells. 2002 Breast Cancer Res. Treat. pmid:12058962
Chajès V et al. Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: relationship to peroxides and vitamin-E. 1995 Breast Cancer Res. Treat. pmid:7579484
Goyal A and Mansel RE A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. 2005 Jan-Feb Breast J pmid:15647077
Sharma N et al. Mastalgia cured! Randomized trial comparing centchroman to evening primrose oil. 2012 Breast J pmid:22892074
Paccalin J et al. [Rediscovery of an oleaginous plant: Oenothera biennis. The importance of gamma-linolenic acid in nutrition]. 1983 Bull. Acad. Natl. Med. pmid:6324965
Girault C et al. Effect of dietary gamma-linolenic acid on specific activities of delta 6 desaturation in obese Zucker rats. 1992 C. R. Seances Soc. Biol. Fil. pmid:1337306
Poulsen RC et al. Specific effects of gamma-linolenic, eicosapentaenoic, and docosahexaenoic ethyl esters on bone post-ovariectomy in rats. 2007 Calcif. Tissue Int. pmid:18008020
Leyton E Disagreeing on how to treat CFS patients. 1993 Can Fam Physician pmid:8347205
Each of the following has been shown to be effective for cyclical breast pain. 1996 Can Fam Physician pmid:8704485
Soma M et al. The effects of hydrogenated coconut oil, safflower oil, and evening primrose oil on development of hypertension and sodium handling in spontaneously hypertensive rats. 1985 Can. J. Physiol. Pharmacol. pmid:4005704
Prociuk MA et al. Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet. 2008 Can. J. Physiol. Pharmacol. pmid:18418423
Harris NM et al. Epirubicin and meglumine gamma-linolenic acid: a logical choice of combination therapy for patients with superficial bladder carcinoma. 2003 Cancer pmid:12491507
González CA et al. Borage consumption as a possible gastric cancer protective factor. 1993 Mar-Apr Cancer Epidemiol. Biomarkers Prev. pmid:8385521
Pham H et al. Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by 15S-hydroxyeicosatrienoic acid parallels growth suppression of androgen-dependent prostatic adenocarcinoma cells. 2003 Cancer Lett. pmid:12445673
Awad AB et al. The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. 1996 Cancer Lett. pmid:8950205
Arimura T et al. Caspase-independent apoptosis induced by evening primrose extract in Ehrlich ascites tumor cells. 2003 Cancer Lett. pmid:14580681
Cantrill RC et al. Exogenous gamma-linolenic acid alters hormone stimulated cyclic AMP levels in U937 cells. 1996 Cancer Lett. pmid:8620439
Ito Y et al. Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. 2001 Cancer Lett. pmid:11165751
Agatha G et al. Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia. 2001 Cancer Lett. pmid:11597788
Cantrill RC et al. Concentration-dependent effect of iron on gamma-linolenic acid toxicity in ZR-75-1 human breast tumor cells in culture. 1993 Cancer Lett. pmid:8402582
Ells GW et al. Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity. 1996 Cancer Lett. pmid:8556710
Ramesh G and Das UN Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. 1998 Cancer Lett. pmid:9489490
Das UN Tumoricidal action of cis-unsaturated fatty acids and their relationship to free radicals and lipid peroxidation. 1991 Cancer Lett. pmid:1850658