gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Guenther L and Wexler D Efamol in the treatment of atopic dermatitis. 1987 J. Am. Acad. Dermatol. pmid:3680673
Ziboh VA and Chapkin RS Biologic significance of polyunsaturated fatty acids in the skin. 1987 Arch Dermatol pmid:3688908
Singh NK et al. Essential fatty acids and cancer with particular reference to Hodgkin's disease. 1987 J Assoc Physicians India pmid:3693269
Das UN et al. Beneficial effect of essential fatty acids in cirrhosis of the liver. 1987 J Assoc Physicians India pmid:3693270
Levy RJ and Lian JB gamma-Carboxyglutamate excretion and warfarin therapy. 1979 Clin. Pharmacol. Ther. pmid:373941
Sugano M et al. Hypocholesterolemic effect of gamma-linolenic acid as evening primrose oil in rats. 1986 Ann. Nutr. Metab. pmid:3752928
Puolakka J et al. Biochemical and clinical effects of treating the premenstrual syndrome with prostaglandin synthesis precursors. 1985 J Reprod Med pmid:3839018
Wright S Atopic dermatitis and essential fatty acids: a biochemical basis for atopy? 1985 Acta Derm Venereol Suppl (Stockh) pmid:3890448
Bamford JT et al. Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids). 1985 J. Am. Acad. Dermatol. pmid:3908514
Kumar S et al. Prediction of response to endocrine therapy in pronounced cyclical mastalgia using dynamic tests of prolactin release. 1985 Clin. Endocrinol. (Oxf) pmid:3938354
Soma M et al. The effects of hydrogenated coconut oil, safflower oil, and evening primrose oil on development of hypertension and sodium handling in spontaneously hypertensive rats. 1985 Can. J. Physiol. Pharmacol. pmid:4005704
Webb J and McCredie M Primary Sjögren's syndrome treated with Efamol/efavit. A double-blind cross-over investigation. 1985 Rheumatol. Int. pmid:4048763
Belch JJ et al. Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. 1985 Thromb. Haemost. pmid:4082084
Strong AM et al. The effect of oral linoleic acid and gamma-linolenic acid (Efamol [G]). 1985 Nov-Dec Br J Clin Pract pmid:4092010
Horrobin DF Essential fatty acid metabolism in diseases of connective tissue with special reference to scleroderma and to Sjogren's syndrome. 1984 Med. Hypotheses pmid:6088955
Mertin J Omega-6 and omega-3 polyunsaturates and the immune system. 1984 Br J Clin Pract Suppl pmid:6091715
Leonard BE Possible relationships between thiamine, carnitine, polyunsaturated fatty acids and the neurotoxicity of alcohol. 1984 Alcohol Alcohol. pmid:6093831
Traitler H et al. Characterization of gamma-linolenic acid in Ribes seed. 1984 Lipids pmid:6098796
Monnier L [Influence of metabolic and nutritional balance on platelet function in insulin-dependent diabetes]. 1984 Journ Annu Diabetol Hotel Dieu pmid:6100381
Lovell CR et al. Treatment of atopic eczema with evening primrose oil. 1981 Lancet pmid:6109930
Wright S and Burton JL Oral evening-primrose-seed oil improves atopic eczema. 1982 Lancet pmid:6128449
Chalmers RJ and Shuster S Evening primrose seed oil in ichthyosis vulgaris. 1983 Lancet pmid:6130264
Horrobin DF A biochemical basis for alcoholism and alcohol-induced damage including the fetal alcohol syndrome and cirrhosis: interference with essential fatty acid and prostaglandin metabolism. 1980 Med. Hypotheses pmid:6253773
Darcet P et al. [Study of the metabolism of fatty acids and total plasma lipids, and platelet aggregation of a population of elderly men using a diet enriched in gamma-linolenic acid]. 1980 Ann Nutr Aliment pmid:6254419
Beitz J et al. Influence of linseed oil diet on the pattern of serum phospholipids in man. 1981 Acta Biol. Med. Ger. pmid:6277115
Bodak A et al. [Comparative study of light and electron microscopic aspects of myocardial lesions induced in the rat by oils with several amounts of gamma-linolenic acid (author's transl)]. 1982 Pathol. Biol. pmid:6278382
Bonacossa A et al. Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. 1982 Prostaglandins pmid:6278538
Huang YS et al. Most biological effects of zinc deficiency corrected by gamma-linolenic acid (18: 3 omega 6) but not by linoleic acid (18: 2 omega 6). 1982 Atherosclerosis pmid:6279122
Simmons DA et al. Significance of tissue myo-inositol concentrations in metabolic regulation in nerve. 1982 Science pmid:6285474
Varma PK and Persaud TV Protection against ethanol-induced embryonic damage by administering gamma-linolenic and linoleic acids. 1982 Prostaglandins Leukot Med pmid:6287501
Leary WP et al. Some effects of gamma-linolenic acid on cultured human oesophageal carcinoma cells. 1982 S. Afr. Med. J. pmid:6291175
Dippenaar N et al. The reversibility of cancer: evidence that malignancy in human hepatoma cells is gamma-linolenic acid deficiency-dependent. 1982 S. Afr. Med. J. pmid:6291176
Renaud S et al. Comparative beneficial effects on platelet functions and atherosclerosis of dietary linoleic and gamma-linolenic acids in the rabbit. 1982 Atherosclerosis pmid:6297517
van der Merwe CF The reversibility of cancer. 1983 S. Afr. Med. J. pmid:6298954
Field EJ and Joyce G Multiple sclerosis: effect of gamma linolenate administration upon membranes and the need for extended clinical trials of unsaturated fatty acids. 1983 Eur. Neurol. pmid:6301844
Hansen TM et al. Treatment of rheumatoid arthritis with prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid. 1983 Scand. J. Rheumatol. pmid:6304871
Botha JH et al. Parenteral gamma-linolenic acid administration in nude mice bearing a range of human tumour xenografts. 1983 S. Afr. Med. J. pmid:6304925
Paccalin J et al. [Changes in the higher derivatives of linoleic acid in cirrhotics treated with gamma-linolenic acid]. 1983 May-Jun Therapie pmid:6310813
Kirstein D et al. Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes. 1983 Br. J. Nutr. pmid:6315055
Kemp P and Lander DJ The hydrogenation of gamma-linolenic acid by pure cultures of two rumen bacteria. 1983 Biochem. J. pmid:6318740
Hamberg M Omega 6-oxygenation of 6, 9, 12-octadecatrienoic acid in human platelets. 1983 Biochem. Biophys. Res. Commun. pmid:6318765
Van der Merwe CF The reversibility of cancer. 1984 S. Afr. Med. J. pmid:6320476
Booyens J and Katzeff IE Cancer: a simple metabolic disease? 1983 Med. Hypotheses pmid:6321917
Hamberg M Isotope effects in enzymatic and non-enzymatic oxygenation of 6,9,12-octadecatrienoic acid. 1984 Biochim. Biophys. Acta pmid:6322853
Chaintreuil J et al. Effects of dietary gamma-linolenate supplementation on serum lipids and platelet function in insulin-dependent diabetic patients. 1984 Hum Nutr Clin Nutr pmid:6323358
Mills DE and Ward R Attenuation of psychosocial stress-induced hypertension by gamma-linolenic acid (GLA) administration in rats. 1984 Proc. Soc. Exp. Biol. Med. pmid:6324224
Booyens J and Koenig L The effect of dietary supplementation with gamma-linolenic acid on the growth of induced tumours in rats. 1984 S. Afr. Med. J. pmid:6324397
Paccalin J et al. [Rediscovery of an oleaginous plant: Oenothera biennis. The importance of gamma-linolenic acid in nutrition]. 1983 Bull. Acad. Natl. Med. pmid:6324965
McCarty MF and Rubin EJ Rationales for micronutrient supplementation in diabetes. 1984 Med. Hypotheses pmid:6325854
van der Merwe CF The reversibility of cancer. 1984 S. Afr. Med. J. pmid:6326340
Manku MS et al. Essential fatty acids in the plasma phospholipids of patients with atopic eczema. 1984 Br. J. Dermatol. pmid:6329254
Sohal RS et al. Relationship between lipofuscin granules and polyunsaturated fatty acids in the housefly, Musca domestica. 1984 Mech. Ageing Dev. pmid:6330462
Hoffman P and Förster W Effects of sunflowerseed oil, linseed oil, evening primrose oil and hydrogenated palm kernel oil on hypertension development in spontaneously hypertensive rats. 1983 Prostaglandins Leukot Med pmid:6348801
Horrobin DF The role of essential fatty acids and prostaglandins in the premenstrual syndrome. 1983 J Reprod Med pmid:6350579
Haslett C et al. A double-blind evaluation of evening primrose oil as an antiobesity agent. 1983 Int J Obes pmid:6360923
Manthorpe R et al. Primary Sjögren's syndrome treated with Efamol/Efavit. A double-blind cross-over investigation. 1984 Rheumatol. Int. pmid:6385206
Olsson AG et al. [Ineffectiveness of Naudicelle in intermittent claudication]. 1984 Lakartidningen pmid:6394928
Weighill VE and Buglass D Weight change and psychological state in obese women. 1984 Appetite pmid:6517571
Phillips JS Oil of the evening primrose. 1984 N. Z. Med. J. pmid:6589527
Hanifin JM Diet, nutrition, and allergy in atopic dermatitis. 1983 J. Am. Acad. Dermatol. pmid:6863636
Kábrt J et al. [Serum lipid concentration in familial hyperlipoproteinemia type IV. Treatment with vitamin C and unsaturated fatty acids]. 1983 Cas. Lek. Cesk. pmid:6871949
Kábrt J et al. [Serum lipid concentrations in familial hyperlipoproteinaemia type IIa. Treatment with unsaturated fatty acids and vitamin C (author's transl)]. 1982 Cas. Lek. Cesk. pmid:7093988
Prencipe M et al. Naudicelle and platelet reactivity in TIA patients. 1982 Ital J Neurol Sci pmid:7166485
Karmali RA et al. Prostaglandins and essential fatty acids in regulation of autoimmunity and development of antibodies to DNA in NZB x NZW F1 mice. 1981 Prog. Lipid Res. pmid:7342118
Kunkel SL et al. Suppression of chronic inflammation by evening primrose oil. 1981 Prog. Lipid Res. pmid:7342138
Lindskov R and Petersen CS [Oral gamma-linoleic acid (Epogam) in the treatment of atopic dermatitis]. 1995 Ugeskr. Laeg. pmid:7483071
Hrelia S et al. Essential fatty acid metabolism in cultured rat cardiomyocytes in response to either N-6 or N-3 fatty acid supplementation. 1995 Biochem. Biophys. Res. Commun. pmid:7488075
Rose DP et al. Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. 1995 Nutr Cancer pmid:7491296
Kietzmann M [Pharmacotherapeutic use of antipruritic drugs in skin diseases]. 1995 Tierarztl Prax pmid:7545832
Larsson-Backström C et al. Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. 1995 Shock pmid:7552772
Rossetti RG et al. Differential regulation of human T lymphocyte protein kinase C activity by unsaturated fatty acids. 1995 Clin. Immunol. Immunopathol. pmid:7554442
Manninen P et al. Separation of gamma- and alpha-linolenic acid containing triacylglycerols by capillary supercritical fluid chromatography. 1995 Lipids pmid:7564922
Chajès V et al. Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: relationship to peroxides and vitamin-E. 1995 Breast Cancer Res. Treat. pmid:7579484
Jiang WG et al. Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). 1995 Cancer Res. pmid:7585549
Claassen N et al. Supplemented gamma-linolenic acid and eicosapentaenoic acid influence bone status in young male rats: effects on free urinary collagen crosslinks, total urinary hydroxyproline, and bone calcium content. 1995 Bone pmid:7626328
Das UN et al. Local application of gamma-linolenic acid in the treatment of human gliomas. 1995 Cancer Lett. pmid:7634242
Akahane N et al. Antithrombotic activity of a symmetrical triglyceride with eicosapentaenoic acid and gamma-linolenic acid in guinea pig mesenteric microvasculature. 1995 Thromb. Res. pmid:7660360
Fan YY et al. Dietary gamma-linolenic acid modulates macrophage-vascular smooth muscle cell interactions. Evidence for a macrophage-derived soluble factor that downregulates DNA synthesis in smooth muscle cells. 1995 Arterioscler. Thromb. Vasc. Biol. pmid:7670954
Sherrington EJ et al. The effect of dietary lipid manipulation on macrophage cell surface molecule expression. 1995 Biochem. Soc. Trans. pmid:7672298
Beno DW et al. Gamma-linolenic acid suppression of hepatic Ito cell mitogenesis: post-PDGF receptor prostaglandin-independent mechanism. 1993 Am. J. Physiol. pmid:7694498
Goldfien A Premenstrual syndrome. 1994 Curr Ther Endocrinol Metab pmid:7704719
Jiang WG et al. Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. 1995 Br. J. Cancer pmid:7710939
Karasu C et al. Effects of anti-oxidant treatment on sciatic nerve dysfunction in streptozotocin-diabetic rats; comparison with essential fatty acids. 1995 Diabetologia pmid:7713308
Dines KC et al. Comparison of the effects of evening primrose oil and triglycerides containing gamma-linolenic acid on nerve conduction and blood flow in diabetic rats. 1995 J. Pharmacol. Exp. Ther. pmid:7714803
Scholey JW and Mills DE Dietary fatty acids and the glomerular hemodynamic response to cyclosporine in borderline hypertensive rats. 1995 Kidney Int. pmid:7723248
Tate GA and Zurier RB Suppression of monosodium urate crystal-induced inflammation by black currant seed oil. 1994 Agents Actions pmid:7741038
Darlington LG and Ramsey NW Review of dietary therapy for rheumatoid arthritis. 1994 Compr Ther pmid:7805365
BeLieu RM Mastodynia. 1994 Obstet. Gynecol. Clin. North Am. pmid:7816407
Berth-Jones J and Graham-Brown RA Evening primrose oil. Does not show promise in atopic dermatitis. 1994 BMJ pmid:7819863
Horrobin DF and Morse PF Evening primrose oil and atopic eczema. 1995 Lancet pmid:7823743
Araya J and Cagalj A [Exclusion of alpha-linolenic acid from diets for rats during several generations. I. Effect on reproduction and postnatal growth]. 1993 Arch Latinoam Nutr pmid:7826185
Hauben M Comment: evening primrose oil in the treatment of rheumatoid arthritis--proper application of statistical analysis. 1994 Jul-Aug Ann Pharmacother pmid:7832860
Guivernau M et al. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846101
McCaul JA and Lamey PJ Multiple oral mucoceles treated with gamma-linolenic acid: report of a case. 1994 Br J Oral Maxillofac Surg pmid:7849001
Falconer JS et al. Polyunsaturated fatty acids in the treatment of weight-losing patients with pancreatic cancer. 1994 World Rev Nutr Diet pmid:7856240
Berth-Jones J et al. Evening primrose oil and atopic eczema. 1995 Lancet pmid:7861894
Tulloch I et al. Evening primrose oil reduces urinary calcium excretion in both normal and hypercalciuric rats. 1994 Urol. Res. pmid:7871634
Purasiri P et al. Modulation of cytokine production in vivo by dietary essential fatty acids in patients with colorectal cancer. 1994 Clin. Sci. pmid:7874864
Cartwright-Shamoon JM et al. A complex biochemical modulation of intestinal ion transport in rats fed on high-fat diets. 1995 J. Pediatr. Gastroenterol. Nutr. pmid:7884616
Cameron NE and Cotter MA Effects of evening primrose oil treatment on sciatic nerve blood flow and endoneurial oxygen tension in streptozotocin-diabetic rats. 1994 Acta Diabetol pmid:7888693