| MeSH term | MeSH ID | Detail |
|---|---|---|
| Fetal Nutrition Disorders | D048070 | 1 associated lipids |
| Ganglion Cysts | D045888 | 1 associated lipids |
| Neuromyelitis Optica | D009471 | 2 associated lipids |
| Acute Pain | D059787 | 3 associated lipids |
| Head Injuries, Closed | D016489 | 5 associated lipids |
| Brain Concussion | D001924 | 5 associated lipids |
| Fragile X Syndrome | D005600 | 5 associated lipids |
| Cholangiocarcinoma | D018281 | 7 associated lipids |
| Hepatic Encephalopathy | D006501 | 9 associated lipids |
| Morphine Dependence | D009021 | 9 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Frazier CJ | Key questions of endocannabinoid signalling in the CNS: which, where and when? | 2011 | J. Physiol. (Lond.) | pmid:22001725 |
| Hill MN et al. | Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. | 2011 | J. Neurosci. | pmid:21775596 |
| Sumislawski JJ et al. | Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. | 2011 | Neuropsychopharmacology | pmid:21849983 |
| Zhong P et al. | Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. | 2011 | J. Physiol. (Lond.) | pmid:21911610 |
| Marazzi J et al. | Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. | 2011 | J. Immunol. Methods | pmid:21920367 |
| Signorello MG et al. | Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway. | 2011 | J. Cell. Biochem. | pmid:21608016 |
| Du H et al. | Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. | 2011 | Br. J. Pharmacol. | pmid:21501147 |
| Raman P et al. | 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. | 2011 | Mol. Pharmacol. | pmid:21511917 |
| Higuchi S et al. | Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors. | 2011 | Behav. Brain Res. | pmid:20817042 |
| Ludányi A et al. | Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. | 2011 | Neuroscience | pmid:21035522 |
| Hofmann ME et al. | Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. | 2011 | J. Physiol. (Lond.) | pmid:21646412 |
| MartÃn-Couce L et al. | Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors. | 2011 | J. Med. Chem. | pmid:21675776 |
| Busquets-Garcia A et al. | Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. | 2011 | Biol. Psychiatry | pmid:21684528 |
| Sarmad S et al. | Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. | 2011 | J. Neurochem. | pmid:21375532 |
| Howlett AC et al. | Endocannabinoid tone versus constitutive activity of cannabinoid receptors. | 2011 | Br. J. Pharmacol. | pmid:21545414 |
| Mulder J et al. | Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. | 2011 | Brain | pmid:21459826 |
| Carr RL et al. | Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. | 2011 | Toxicol. Sci. | pmid:21507991 |
| Chiba T et al. | A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. | 2011 | J. Pharm. Pharmacol. | pmid:21492165 |
| Vecchio AJ and Malkowski MG | The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. | 2011 | J. Biol. Chem. | pmid:21489986 |
| Balenga NA et al. | GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. | 2011 | Cell Res. | pmid:21467997 |
| Chen X et al. | Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults. | 2011 | Neuroscience | pmid:21256197 |
| Yoshida T et al. | Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21282604 |
| Liao HT et al. | Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition. | 2011 | Br. J. Pharmacol. | pmid:21232043 |
| Soderstrom K et al. | Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness. | 2011 | BMC Neurosci | pmid:21211022 |
| De Petrocellis L et al. | Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. | 2011 | Br. J. Pharmacol. | pmid:21175579 |
| Petrosino S et al. | Alteration of the endocannabinoid system in mouse brain during prion disease. | 2011 | Neuroscience | pmid:21195746 |
| Jumpertz R et al. | Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. | 2011 | J. Clin. Endocrinol. Metab. | pmid:21177788 |
| Sciolino NR et al. | Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. | 2011 | Pharmacol. Res. | pmid:21600985 |
| Uchigashima M et al. | Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. | 2011 | J. Neurosci. | pmid:21613483 |
| Alhouayek M et al. | Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. | 2011 | FASEB J. | pmid:21551239 |
| Justinová Z et al. | The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys. | 2011 | J. Neurosci. | pmid:21562266 |
| Guindon J et al. | Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. | 2011 | Br. J. Pharmacol. | pmid:21198549 |
| Shekhar C | Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. | 2011 | Chem. Biol. | pmid:21609833 |
| Ho YC et al. | Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition. | 2011 | J. Neurosci. | pmid:21994376 |
| Cippitelli A et al. | Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. | 2011 | PLoS ONE | pmid:22140525 |
| Brizzi A et al. | Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor. | 2011 | J. Med. Chem. | pmid:22044209 |
| Yoshino H et al. | Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. | 2011 | J. Physiol. (Lond.) | pmid:21807615 |
| Chouinard F et al. | The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis. | 2011 | J. Immunol. | pmid:21278347 |
| Khasabova IA et al. | Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. | 2011 | Pharmacol. Res. | pmid:21440630 |
| Catanzaro G et al. | Effect of capacitation on the endocannabinoid system of mouse sperm. | 2011 | Mol. Cell. Endocrinol. | pmid:21723369 |
| Urbanski MJ et al. | Endocannabinoid-mediated synaptically evoked suppression of GABAergic transmission in the cerebellar cortex. | 2010 | Neuroscience | pmid:20553815 |
| Smith SL and Rasmussen EB | Effects of 2-AG on the reinforcing properties of wheel activity in obese and lean Zucker rats. | 2010 | Behav Pharmacol | pmid:20512031 |
| Mecs L et al. | Peripheral antinociceptive effect of 2-arachidonoyl-glycerol and its interaction with endomorphin-1 in arthritic rat ankle joints. | 2010 | Clin. Exp. Pharmacol. Physiol. | pmid:20529093 |
| Carrasquer A et al. | Functional consequences of nonsynonymous single nucleotide polymorphisms in the CB2 cannabinoid receptor. | 2010 | Pharmacogenet. Genomics | pmid:20124950 |
| Gao Y et al. | Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. | 2010 | J. Neurosci. | pmid:20147530 |
| Best AR and Regehr WG | Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain. | 2010 | Neuron | pmid:20159441 |
| Yasuo S et al. | An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes. | 2010 | Cell Tissue Res. | pmid:20165884 |
| Casida JE et al. | S-Arachidonoyl-2-thioglycerol synthesis and use for fluorimetric and colorimetric assays of monoacylglycerol lipase. | 2010 | Bioorg. Med. Chem. | pmid:20138526 |
| Guida M et al. | The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma. | 2010 | Endocrinology | pmid:20133454 |
| Lourenço J et al. | Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. | 2010 | Nat. Neurosci. | pmid:20081851 |
| Amorós I et al. | Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner. | 2010 | J. Mol. Cell. Cardiol. | pmid:19616555 |
| Frampton G et al. | Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling. | 2010 | Exp. Cell Res. | pmid:20347808 |
| Kim J and Alger BE | Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. | 2010 | Nat. Neurosci. | pmid:20348918 |
| Hoot MR et al. | Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. | 2010 | Brain Res. | pmid:20380816 |
| Musella A et al. | Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum. | 2010 | Neuroscience | pmid:20219639 |
| Caraceni P et al. | Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. | 2010 | Liver Int. | pmid:19840245 |
| Sagar DR et al. | Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. | 2010 | Arthritis Rheum. | pmid:20722027 |
| Jiang S et al. | Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. | 2010 | J. Biol. Chem. | pmid:20826813 |
| Piccinetti CC et al. | Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. | 2010 | Gen. Comp. Endocrinol. | pmid:19800340 |
| Banni S and Di Marzo V | Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood. | 2010 | Mol Nutr Food Res | pmid:20013888 |
| Romigi A et al. | Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. | 2010 | Epilepsia | pmid:19817812 |
| Ying-Ying Y and Lin HC | Endocannabinoids and non-endocannabinoid fatty acid amides in cirrhosis. | 2010 | Liver Int. | pmid:20408944 |
| Spradley JM et al. | Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. | 2010 | Pharmacol. Res. | pmid:20416378 |
| Placzek EA et al. | Lipidomic metabolism analysis of the endogenous cannabinoid anandamide (N-arachidonylethanolamide). | 2010 | J Pharm Biomed Anal | pmid:20417049 |
| Massa F et al. | Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. | 2010 | J. Neurosci. | pmid:20445053 |
| Bardell TK and Barker EL | Activation of TRPC6 channels promotes endocannabinoid biosynthesis in neuronal CAD cells. | 2010 | Neurochem. Int. | pmid:20466028 |
| Naccarato M et al. | Possible Anandamide and Palmitoylethanolamide involvement in human stroke. | 2010 | Lipids Health Dis | pmid:20470384 |
| Muccioli GG | Endocannabinoid biosynthesis and inactivation, from simple to complex. | 2010 | Drug Discov. Today | pmid:20304091 |
| Kozono S et al. | Involvement of the endocannabinoid system in periodontal healing. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20233580 |
| Mukhopadhyay P et al. | CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. | 2010 | Br. J. Pharmacol. | pmid:20590569 |
| Gutierrez-Lopez MD et al. | Involvement of 2-arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine. | 2010 | Br. J. Pharmacol. | pmid:20590579 |
| Keimpema E et al. | Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. | 2010 | J. Neurosci. | pmid:20962221 |
| Farkas I et al. | Retrograde endocannabinoid signaling reduces GABAergic synaptic transmission to gonadotropin-releasing hormone neurons. | 2010 | Endocrinology | pmid:20926585 |
| Muccioli GG et al. | The endocannabinoid system links gut microbiota to adipogenesis. | 2010 | Mol. Syst. Biol. | pmid:20664638 |
| Suárez J et al. | Endocannabinoid system in the adult rat circumventricular areas: an immunohistochemical study. | 2010 | J. Comp. Neurol. | pmid:20533360 |
| Gomez O et al. | The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation. | 2010 | Glia | pmid:20878765 |
| Lichtman AH et al. | Endocannabinoid overload. | 2010 | Mol. Pharmacol. | pmid:20952498 |
| Jumpertz R et al. | Circulating endocannabinoids and N-acyl-ethanolamides in patients with sleep apnea--specific role of oleoylethanolamide. | 2010 | Exp. Clin. Endocrinol. Diabetes | pmid:20429051 |
| Lerner TN et al. | Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. | 2010 | J. Neurosci. | pmid:20147543 |
| Reggio PH | Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. | 2010 | Curr. Med. Chem. | pmid:20166921 |
| Higuchi S et al. | Reducing acyl migration during purification of 2-arachidonoylglycerol from biological samples before gas chromatography mass spectrometry analysis. | 2010 | Anal Sci | pmid:21079352 |
| Weis F et al. | Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure. | 2010 | J. Mol. Cell. Cardiol. | pmid:19931541 |
| Sang N et al. | Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway. | 2010 | Neurochem. Int. | pmid:20064571 |
| Duclos RI | The total synthesis of 2-O-arachidonoyl-1-O-stearoyl-sn-glycero-3-phosphocholine-1,3,1'-(13)C3 and -2,1'-(13)C2 by a novel chemoenzymatic method. | 2010 | Chem. Phys. Lipids | pmid:19682980 |
| Lane JR et al. | The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor. | 2010 | Biochem. Pharmacol. | pmid:19665453 |
| Ishii Y et al. | F2-isoprostanes and 2-arachidonylglycerol as biomarkers of lipid peroxidation in pigs with hepatic ischemia/reperfusion injury. | 2010 | J. Surg. Res. | pmid:19439322 |
| Bradshaw H | CB1-induced side effects of specific COX-2 inhibitors: a feature, not a bug. | 2010 | Pain | pmid:19913999 |
| Zhang MY et al. | Simultaneous determination of 2-arachidonoylglycerol, 1-arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry. | 2010 | J Mass Spectrom | pmid:19950120 |
| Labar G et al. | Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. | 2010 | Chembiochem | pmid:19957260 |
| Jyotaki M et al. | Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors. | 2010 | Endocr. J. | pmid:20431269 |
| Mukhopadhyay B et al. | Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. | 2010 | J. Biol. Chem. | pmid:20410309 |
| Maccarrone M | Endocannabinoid-binding receptors: old friends and new comers. | 2010 | Curr. Med. Chem. | pmid:20441559 |
| Skonberg C et al. | Pitfalls in the sample preparation and analysis of N-acylethanolamines. | 2010 | J. Lipid Res. | pmid:20447930 |
| Fino E et al. | Distinct coincidence detectors govern the corticostriatal spike timing-dependent plasticity. | 2010 | J. Physiol. (Lond.) | pmid:20603333 |
| Keown OP et al. | 2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors. | 2010 | Br J Clin Pharmacol | pmid:20653671 |
| Ho WS et al. | Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex. | 2010 | Br. J. Pharmacol. | pmid:20590576 |
| Breunig E et al. | The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. | 2010 | J. Neurosci. | pmid:20592217 |
| Marrs WR et al. | The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. | 2010 | Nat. Neurosci. | pmid:20657592 |
| Shimizu T et al. | Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats. | 2010 | Eur. J. Pharmacol. | pmid:20519139 |
| Haj-Dahmane S and Shen RY | Regulation of plasticity of glutamate synapses by endocannabinoids and the cyclic-AMP/protein kinase A pathway in midbrain dopamine neurons. | 2010 | J. Physiol. (Lond.) | pmid:20498231 |