| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alzheimer Disease | D000544 | 76 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Concussion | D001924 | 5 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fezza F et al. | Endocannabinoids, related compounds and their metabolic routes. | 2014 | Molecules | pmid:25347455 |
| Flores-Otero J et al. | Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. | 2014 | Nat Commun | pmid:25081814 |
| Bluett RJ et al. | Endocannabinoid signalling modulates susceptibility to traumatic stress exposure. | 2017 | Nat Commun | pmid:28348378 |
| Tung LW et al. | Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. | 2016 | Nat Commun | pmid:27448020 |
| Jung KM et al. | Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. | 2012 | Nat Commun | pmid:23011134 |
| Alpár A et al. | Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. | 2014 | Nat Commun | pmid:25030704 |
| Iannotti FA et al. | Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy. | 2018 | Nat Commun | pmid:30262909 |
| Duggan KC et al. | (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. | 2011 | Nat. Chem. Biol. | pmid:22053353 |
| Hsu KL et al. | DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. | 2012 | Nat. Chem. Biol. | pmid:23103940 |
| Nomura DK et al. | Activation of the endocannabinoid system by organophosphorus nerve agents. | 2008 | Nat. Chem. Biol. | pmid:18438404 |
| Long JZ et al. | Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. | 2009 | Nat. Chem. Biol. | pmid:19029917 |
| Kim J and Alger BE | Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. | 2004 | Nat. Neurosci. | pmid:15184902 |
| Lourenço J et al. | Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. | 2010 | Nat. Neurosci. | pmid:20081851 |
| Self DW | Anandamide: a candidate neurotransmitter heads for the big leagues. | 1999 | Nat. Neurosci. | pmid:10204533 |
| Giuffrida A et al. | Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. | 1999 | Nat. Neurosci. | pmid:10204543 |
| Shonesy BC et al. | CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling. | 2013 | Nat. Neurosci. | pmid:23502535 |
| Kim J and Alger BE | Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. | 2010 | Nat. Neurosci. | pmid:20348918 |
| Maccarrone M et al. | Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. | 2008 | Nat. Neurosci. | pmid:18204441 |
| Di Marzo V | Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. | 2011 | Nat. Neurosci. | pmid:21187849 |
| Marrs WR et al. | The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. | 2010 | Nat. Neurosci. | pmid:20657592 |