| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acute Pain | D059787 | 3 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Fetal Nutrition Disorders | D048070 | 1 associated lipids |
| Ganglion Cysts | D045888 | 1 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Cholangiocarcinoma | D018281 | 7 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Baggelaar MP et al. | Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:24173880 |
| Ueda N et al. | Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways. | 2013 | FEBS J. | pmid:23425575 |
| Sugaya Y et al. | The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus. | 2013 | J. Neurosci. | pmid:23426686 |
| DiPatrizio NV et al. | Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. | 2013 | FASEB J. | pmid:23463697 |
| Yuan S and Burrell BD | Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation. | 2013 | J. Neurosci. | pmid:23467351 |
| Kinsey SG et al. | Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23412396 |
| Rea K et al. | Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats. | 2013 | Pain | pmid:23414578 |
| Shonesy BC et al. | CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling. | 2013 | Nat. Neurosci. | pmid:23502535 |
| Siegmund SV et al. | Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23806692 |
| Keimpema E et al. | Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling. | 2013 | Sci Rep | pmid:23806960 |
| Pérez-Morales M et al. | 2-AG into the lateral hypothalamus increases REM sleep and cFos expression in melanin concentrating hormone neurons in rats. | 2013 | Pharmacol. Biochem. Behav. | pmid:23603032 |
| Chiou LC et al. | Targeting the cannabinoid system for pain relief? | 2013 | Acta Anaesthesiol Taiwan | pmid:24529672 |
| Cristino L et al. | Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23630288 |
| Barricklow J and Blatnik M | 2-Arachidonoylglycerol is a substrate for butyrylcholinesterase: A potential mechanism for extracellular endocannabinoid regulation. | 2013 | Arch. Biochem. Biophys. | pmid:23689009 |
| Bari M et al. | In vitro and in vivo models of Huntington's disease show alterations in the endocannabinoid system. | 2013 | FEBS J. | pmid:23659592 |
| Chouinard F et al. | 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV. | 2013 | J. Leukoc. Biol. | pmid:23242611 |
| Iannotti FA et al. | Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23830028 |
| Almeida-Santos AF et al. | Modulation of anxiety-like behavior by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray. | 2013 | Behav. Brain Res. | pmid:23714073 |
| Perez-Rosello T et al. | Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis. | 2013 | J. Neurosci. | pmid:23719795 |
| Yang Y et al. | Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. | 2013 | Cell. Signal. | pmid:23142606 |
| Sticht MA et al. | 2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus. | 2013 | Physiol. Behav. | pmid:23958470 |
| Chanda D et al. | Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH. | 2013 | PLoS ONE | pmid:23894352 |
| Pellkofer HL et al. | The major brain endocannabinoid 2-AG controls neuropathic pain and mechanical hyperalgesia in patients with neuromyelitis optica. | 2013 | PLoS ONE | pmid:23951176 |
| Costola-de-Souza C et al. | Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice. | 2013 | PLoS ONE | pmid:24204926 |
| Du H et al. | Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG. | 2013 | J. Neurosci. | pmid:24048832 |
| Guindon J et al. | Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. | 2013 | Pharmacol. Res. | pmid:23127915 |
| Hashimotodani Y et al. | Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: evidence for on-demand biosynthesis of 2-arachidonoylglycerol. | 2013 | J. Physiol. (Lond.) | pmid:23858009 |
| Kerr DM et al. | The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. | 2013 | Br. J. Pharmacol. | pmid:23043675 |
| Han B et al. | Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor. | 2013 | Anal. Biochem. | pmid:23044255 |
| Carr RL et al. | Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure. | 2013 | Toxicol. Sci. | pmid:23761300 |
| Ilayan E et al. | Do cannabinoids exhibit a tyramine-like effect? | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23900610 |
| Krumbholz A et al. | Diagnostic value of concentration profiles of glucocorticosteroids and endocannabinoids in hair. | 2013 | Ther Drug Monit | pmid:23942543 |
| Blasio A et al. | Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala. | 2013 | Neuropsychopharmacology | pmid:23793355 |
| Gesell FK et al. | Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. | 2013 | BMC Vet. Res. | pmid:24370333 |
| Fonseca BM et al. | Endogenous cannabinoids revisited: a biochemistry perspective. | 2013 Apr-May | Prostaglandins Other Lipid Mediat. | pmid:23474290 |
| Pascual AC et al. | Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. | 2013 Mar-Apr | Biofactors | pmid:23281018 |
| Fezza F et al. | Endocannabinoids, related compounds and their metabolic routes. | 2014 | Molecules | pmid:25347455 |
| Tsurumura T and Tsuge H | Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure. | 2014 | J. Struct. Funct. Genomics | pmid:24894647 |
| Pascual AC et al. | Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging. | 2014 | Exp. Gerontol. | pmid:24768821 |
| Khasabova IA et al. | JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. | 2014 | Pharmacol. Res. | pmid:25304184 |
| McDougle DR et al. | Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. | 2014 | J. Pharmacol. Exp. Ther. | pmid:25277139 |
| Özdemir B et al. | Endocannabinoids and inflammatory response in periodontal ligament cells. | 2014 | PLoS ONE | pmid:25226300 |
| Navarria A et al. | The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. | 2014 | Pharmacol. Res. | pmid:24861565 |
| Oleson EB et al. | Cannabinoid receptor activation shifts temporally engendered patterns of dopamine release. | 2014 | Neuropsychopharmacology | pmid:24345819 |
| Brantl SA et al. | Mechanism of platelet activation induced by endocannabinoids in blood and plasma. | 2014 | Platelets | pmid:23789792 |
| Koltyn KF et al. | Mechanisms of exercise-induced hypoalgesia. | 2014 | J Pain | pmid:25261342 |
| Alvheim AR et al. | Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet. | 2014 | Lipids | pmid:24081493 |
| Jergas B et al. | O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus. | 2014 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:24853577 |
| Kim J and Watkins BA | Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity. | 2014 | J. Nutr. Biochem. | pmid:24854955 |
| Manna JD et al. | Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. | 2014 | J. Biol. Chem. | pmid:25301951 |