2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Frazier CJ | Key questions of endocannabinoid signalling in the CNS: which, where and when? | 2011 | J. Physiol. (Lond.) | pmid:22001725 |
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Stella N | Cell biology. Anatomy of prostaglandin signals. | 2011 | Science | pmid:22076368 |
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Hill MN et al. | Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. | 2011 | J. Neurosci. | pmid:21775596 |
Sumislawski JJ et al. | Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. | 2011 | Neuropsychopharmacology | pmid:21849983 |
Zhong P et al. | Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. | 2011 | J. Physiol. (Lond.) | pmid:21911610 |
Marazzi J et al. | Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. | 2011 | J. Immunol. Methods | pmid:21920367 |
Signorello MG et al. | Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway. | 2011 | J. Cell. Biochem. | pmid:21608016 |
Bari M et al. | Characterization of the endocannabinoid system in mouse embryonic stem cells. | 2011 | Stem Cells Dev. | pmid:20446814 |
Higuchi S et al. | Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors. | 2011 | Behav. Brain Res. | pmid:20817042 |
Ludányi A et al. | Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. | 2011 | Neuroscience | pmid:21035522 |
Chanda D et al. | Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes. | 2011 | J. Biol. Chem. | pmid:21693703 |
Signorello MG et al. | Activation of human platelets by 2-arachidonoylglycerol: role of PKC in NO/cGMP pathway modulation. | 2011 | Curr Neurovasc Res | pmid:21675954 |
Marrs WR et al. | Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. | 2011 | J. Biol. Chem. | pmid:21665953 |
Gantayet A et al. | Endocannabinoids and diacylglycerol kinase activity. | 2011 | Biochim. Biophys. Acta | pmid:21194521 |
Duclos RI et al. | A methodology for radiolabeling of the endocannabinoid 2-arachidonoylglycerol (2-AG). | 2011 | J. Org. Chem. | pmid:21370840 |
Shimizu T et al. | Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in bombesin-induced activation of central adrenomedullary outflow in rats. | 2011 | Eur. J. Pharmacol. | pmid:21371452 |
Lourbopoulos A et al. | Administration of 2-arachidonoylglycerol ameliorates both acute and chronic experimental autoimmune encephalomyelitis. | 2011 | Brain Res. | pmid:21406188 |
Kortleven C et al. | The endocannabinoid 2-arachidonoylglycerol inhibits long-term potentiation of glutamatergic synapses onto ventral tegmental area dopamine neurons in mice. | 2011 | Eur. J. Neurosci. | pmid:21410793 |
Oudin MJ et al. | Endocannabinoids regulate the migration of subventricular zone-derived neuroblasts in the postnatal brain. | 2011 | J. Neurosci. | pmid:21411643 |
Hashimotodani Y et al. | Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol. | 2011 | J. Neurosci. | pmid:21414931 |
Chiba T et al. | A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. | 2011 | J. Pharm. Pharmacol. | pmid:21492165 |
Soderstrom K et al. | Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness. | 2011 | BMC Neurosci | pmid:21211022 |
Petrosino S et al. | Alteration of the endocannabinoid system in mouse brain during prion disease. | 2011 | Neuroscience | pmid:21195746 |
Sciolino NR et al. | Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. | 2011 | Pharmacol. Res. | pmid:21600985 |
Uchigashima M et al. | Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. | 2011 | J. Neurosci. | pmid:21613483 |
Di Marzo V | Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. | 2011 | Nat. Neurosci. | pmid:21187849 |
Alhouayek M et al. | Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. | 2011 | FASEB J. | pmid:21551239 |
Justinová Z et al. | The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys. | 2011 | J. Neurosci. | pmid:21562266 |
Borges BC et al. | Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21343543 |
Ho YC et al. | Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition. | 2011 | J. Neurosci. | pmid:21994376 |
Quercioli A et al. | Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. | 2011 | Eur. Heart J. | pmid:21303779 |
Cippitelli A et al. | Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. | 2011 | PLoS ONE | pmid:22140525 |
Yoshino H et al. | Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. | 2011 | J. Physiol. (Lond.) | pmid:21807615 |
Urbanski MJ et al. | Endocannabinoid-mediated synaptically evoked suppression of GABAergic transmission in the cerebellar cortex. | 2010 | Neuroscience | pmid:20553815 |
Smith SL and Rasmussen EB | Effects of 2-AG on the reinforcing properties of wheel activity in obese and lean Zucker rats. | 2010 | Behav Pharmacol | pmid:20512031 |
Greco R et al. | Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat. | 2010 | Cephalalgia | pmid:19515121 |
Keimpema E et al. | Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. | 2010 | J. Neurosci. | pmid:20962221 |
Farkas I et al. | Retrograde endocannabinoid signaling reduces GABAergic synaptic transmission to gonadotropin-releasing hormone neurons. | 2010 | Endocrinology | pmid:20926585 |
Ho WS et al. | Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex. | 2010 | Br. J. Pharmacol. | pmid:20590576 |
Breunig E et al. | The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. | 2010 | J. Neurosci. | pmid:20592217 |
Marrs WR et al. | The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. | 2010 | Nat. Neurosci. | pmid:20657592 |
Shimizu T et al. | Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats. | 2010 | Eur. J. Pharmacol. | pmid:20519139 |
Haj-Dahmane S and Shen RY | Regulation of plasticity of glutamate synapses by endocannabinoids and the cyclic-AMP/protein kinase A pathway in midbrain dopamine neurons. | 2010 | J. Physiol. (Lond.) | pmid:20498231 |