2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Gantayet A et al. | Endocannabinoids and diacylglycerol kinase activity. | 2011 | Biochim. Biophys. Acta | pmid:21194521 |
Petrosino S et al. | Alteration of the endocannabinoid system in mouse brain during prion disease. | 2011 | Neuroscience | pmid:21195746 |
Guindon J et al. | Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. | 2011 | Br. J. Pharmacol. | pmid:21198549 |
Soderstrom K et al. | Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness. | 2011 | BMC Neurosci | pmid:21211022 |
Liao HT et al. | Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition. | 2011 | Br. J. Pharmacol. | pmid:21232043 |
Chen X et al. | Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults. | 2011 | Neuroscience | pmid:21256197 |
Chouinard F et al. | The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis. | 2011 | J. Immunol. | pmid:21278347 |
Yoshida T et al. | Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21282604 |
Quercioli A et al. | Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. | 2011 | Eur. Heart J. | pmid:21303779 |
Zhang L et al. | Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase. | 2011 | PLoS ONE | pmid:21305054 |
Schalk-Hihi C et al. | Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Ã… resolution. | 2011 | Protein Sci. | pmid:21308848 |
Ueda N et al. | Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol. | 2011 Jan-Feb | Biofactors | pmid:21328621 |
Borges BC et al. | Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21343543 |
Duclos RI et al. | A methodology for radiolabeling of the endocannabinoid 2-arachidonoylglycerol (2-AG). | 2011 | J. Org. Chem. | pmid:21370840 |
Shimizu T et al. | Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in bombesin-induced activation of central adrenomedullary outflow in rats. | 2011 | Eur. J. Pharmacol. | pmid:21371452 |
Sarmad S et al. | Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. | 2011 | J. Neurochem. | pmid:21375532 |
Lourbopoulos A et al. | Administration of 2-arachidonoylglycerol ameliorates both acute and chronic experimental autoimmune encephalomyelitis. | 2011 | Brain Res. | pmid:21406188 |
Kortleven C et al. | The endocannabinoid 2-arachidonoylglycerol inhibits long-term potentiation of glutamatergic synapses onto ventral tegmental area dopamine neurons in mice. | 2011 | Eur. J. Neurosci. | pmid:21410793 |
Oudin MJ et al. | Endocannabinoids regulate the migration of subventricular zone-derived neuroblasts in the postnatal brain. | 2011 | J. Neurosci. | pmid:21411643 |
Hashimotodani Y et al. | Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol. | 2011 | J. Neurosci. | pmid:21414931 |
Savinainen JR et al. | The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors. | 2012 | Acta Physiol (Oxf) | pmid:21418147 |
Khasabova IA et al. | Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. | 2011 | Pharmacol. Res. | pmid:21440630 |
Taschler U et al. | Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. | 2011 | J. Biol. Chem. | pmid:21454566 |
Mulder J et al. | Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. | 2011 | Brain | pmid:21459826 |
Balenga NA et al. | GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. | 2011 | Cell Res. | pmid:21467997 |
Sticht MA et al. | Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats. | 2012 | Br. J. Pharmacol. | pmid:21470205 |
Vecchio AJ and Malkowski MG | The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. | 2011 | J. Biol. Chem. | pmid:21489986 |
Chiba T et al. | A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. | 2011 | J. Pharm. Pharmacol. | pmid:21492165 |
Du H et al. | Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. | 2011 | Br. J. Pharmacol. | pmid:21501147 |
Booker L et al. | The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. | 2012 | Br. J. Pharmacol. | pmid:21506952 |
Carr RL et al. | Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. | 2011 | Toxicol. Sci. | pmid:21507991 |
Raman P et al. | 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. | 2011 | Mol. Pharmacol. | pmid:21511917 |
Howlett AC et al. | Endocannabinoid tone versus constitutive activity of cannabinoid receptors. | 2011 | Br. J. Pharmacol. | pmid:21545414 |
Alhouayek M et al. | Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. | 2011 | FASEB J. | pmid:21551239 |
Justinová Z et al. | The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys. | 2011 | J. Neurosci. | pmid:21562266 |
Sciolino NR et al. | Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. | 2011 | Pharmacol. Res. | pmid:21600985 |
Signorello MG et al. | Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway. | 2011 | J. Cell. Biochem. | pmid:21608016 |
Shekhar C | Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. | 2011 | Chem. Biol. | pmid:21609833 |
Uchigashima M et al. | Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. | 2011 | J. Neurosci. | pmid:21613483 |
Hofmann ME et al. | Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. | 2011 | J. Physiol. (Lond.) | pmid:21646412 |
Whyte LS et al. | Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro. | 2012 | Br. J. Pharmacol. | pmid:21649637 |
Marrs WR et al. | Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. | 2011 | J. Biol. Chem. | pmid:21665953 |
MartÃn-Couce L et al. | Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors. | 2011 | J. Med. Chem. | pmid:21675776 |
Signorello MG et al. | Activation of human platelets by 2-arachidonoylglycerol: role of PKC in NO/cGMP pathway modulation. | 2011 | Curr Neurovasc Res | pmid:21675954 |
Busquets-Garcia A et al. | Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. | 2011 | Biol. Psychiatry | pmid:21684528 |
Chanda D et al. | Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes. | 2011 | J. Biol. Chem. | pmid:21693703 |
Catanzaro G et al. | Effect of capacitation on the endocannabinoid system of mouse sperm. | 2011 | Mol. Cell. Endocrinol. | pmid:21723369 |
Zoerner AA et al. | Simultaneous UPLC-MS/MS quantification of the endocannabinoids 2-arachidonoyl glycerol (2AG), 1-arachidonoyl glycerol (1AG), and anandamide in human plasma: minimization of matrix-effects, 2AG/1AG isomerization and degradation by toluene solvent extraction. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21752730 |
Hill MN et al. | Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. | 2011 | J. Neurosci. | pmid:21775596 |
Yoshino H et al. | Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. | 2011 | J. Physiol. (Lond.) | pmid:21807615 |