2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Labar G et al. | Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling. | 2007 | Chembiochem | pmid:17579916 |
Sang N et al. | COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity. | 2007 | J. Neurochem. | pmid:17539917 |
Jung KM et al. | A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. | 2007 | Mol. Pharmacol. | pmid:17584991 |
Suhara Y et al. | Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. | 2007 | Bioorg. Med. Chem. | pmid:17110113 |
Yu Y et al. | Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. | 2007 | J. Biol. Chem. | pmid:17110378 |
Straiker A and Mackie K | Metabotropic suppression of excitation in murine autaptic hippocampal neurons. | 2007 | J. Physiol. (Lond.) | pmid:17110416 |
Waku K | [Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol]. | 2006 | Yakugaku Zasshi | pmid:16462096 |
Guagnini F et al. | Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. | 2006 | Gut | pmid:16423891 |
Avraham Y et al. | Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice. | 2006 | Neurobiol. Dis. | pmid:16102970 |
D'Argenio G et al. | Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. | 2006 | FASEB J. | pmid:16403786 |
Suplita RL et al. | Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. | 2006 | Neuropharmacology | pmid:16316669 |
Juan-Picó P et al. | Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. | 2006 | Cell Calcium | pmid:16321437 |
Oka S et al. | Suppression by WIN55212-2, a cannabinoid receptor agonist, of inflammatory reactions in mouse ear: Interference with the actions of an endogenous ligand, 2-arachidonoylglycerol. | 2006 | Eur. J. Pharmacol. | pmid:16647054 |
Melis M et al. | Protective activation of the endocannabinoid system during ischemia in dopamine neurons. | 2006 | Neurobiol. Dis. | pmid:16762556 |
Malcher-Lopes R et al. | Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. | 2006 | J. Neurosci. | pmid:16775153 |
Kishimoto S et al. | Chemotaxis of human peripheral blood eosinophils to 2-arachidonoylglycerol: comparison with other eosinophil chemoattractants. | 2006 | Int. Arch. Allergy Immunol. | pmid:16772720 |
Hermann A et al. | 2-Arachidonoylglycerol (2-AG) membrane transport: history and outlook. | 2006 | AAPS J | pmid:16808043 |
Yoshida T et al. | Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. | 2006 | J. Neurosci. | pmid:16672646 |
Sugiura T et al. | Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. | 2006 | Prog. Lipid Res. | pmid:16678907 |
Katona I et al. | Molecular composition of the endocannabinoid system at glutamatergic synapses. | 2006 | J. Neurosci. | pmid:16723519 |