2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fowler CJ et al. | Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. | 2001 | Biochem. Pharmacol. | pmid:11585048 |
Baker D et al. | Endocannabinoids control spasticity in a multiple sclerosis model. | 2001 | FASEB J. | pmid:11156943 |
MacCarrone M et al. | Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor. | 2001 | Eur. J. Biochem. | pmid:11168423 |
Al-Hayani A et al. | The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice. | 2001 | Neuropharmacology | pmid:11747904 |
Kagota S et al. | 2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor. | 2001 | Eur. J. Pharmacol. | pmid:11275004 |
Wang Y et al. | Simultaneous measurement of anandamide and 2-arachidonoylglycerol by polymyxin B-selective adsorption and subsequent high-performance liquid chromatography analysis: increase in endogenous cannabinoids in the sera of patients with endotoxic shock. | 2001 | Anal. Biochem. | pmid:11412008 |
Maccarrone M et al. | Gas chromatography-mass spectrometry analysis of endogenous cannabinoids in healthy and tumoral human brain and human cells in culture. | 2001 | J. Neurochem. | pmid:11208922 |
Berdyshev EV et al. | Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cells. | 2001 | FASEB J. | pmid:11641243 |
Sugiura T and Waku K | 2-arachidonoylglycerol: a possible multifunctional lipid mediator in the nervous and immune systems. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818479 |
Sinor AD et al. | Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats. | 2000 | Neurosci. Lett. | pmid:10653017 |
Sugiura T et al. | Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10814517 |
Basavarajappa BS et al. | Stimulation of cannabinoid receptor agonist 2-arachidonylglycerol by chronic ethanol and its modulation by specific neuromodulators in cerebellar granule neurons. | 2000 | Biochim. Biophys. Acta | pmid:11113634 |
Pryor SR | Is platelet release of 2-arachidonoyl-glycerol a mediator of cognitive deficits? An endocannabinoid theory of schizophrenia and arousal. | 2000 | Med. Hypotheses | pmid:11090297 |
Rhee MH et al. | Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor. | 2000 | J. Neurochem. | pmid:11080201 |
Melck D et al. | Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. | 2000 | Endocrinology | pmid:10614630 |
Hillard CJ | Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785538 |
Di Marzo V et al. | Cannabimimetic fatty acid derivatives in cancer and inflammation. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785541 |
Kunos G et al. | Cardiovascular effects of endocannabinoids--the plot thickens. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785543 |
Schmid PC et al. | A sensitive endocannabinoid assay. The simultaneous analysis of N-acylethanolamines and 2-monoacylglycerols. | 2000 | Chem. Phys. Lipids | pmid:10669310 |
González S et al. | Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733937 |