2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Inflammation D007249 119 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Alzheimer Disease D000544 76 associated lipids
Stomach Ulcer D013276 75 associated lipids
Colitis D003092 69 associated lipids
Reperfusion Injury D015427 65 associated lipids
Pain D010146 64 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Nerve Degeneration D009410 53 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Starvation D013217 47 associated lipids
Hyperalgesia D006930 42 associated lipids
Hypotension D007022 41 associated lipids
Nervous System Diseases D009422 37 associated lipids
Epilepsy D004827 35 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Memory Disorders D008569 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Catalepsy D002375 30 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Obesity D009765 29 associated lipids
Neuralgia D009437 28 associated lipids
Hyperinsulinism D006946 27 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Brain Edema D001929 20 associated lipids
Hypothermia D007035 19 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Encephalitis D004660 15 associated lipids
Hyperkinesis D006948 11 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Morphine Dependence D009021 9 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Brain Concussion D001924 5 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Head Injuries, Closed D016489 5 associated lipids
Acute Pain D059787 3 associated lipids
Neuromyelitis Optica D009471 2 associated lipids
Fetal Nutrition Disorders D048070 1 associated lipids
Ganglion Cysts D045888 1 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

Download all related citations
Per page 10 20 50 100 | Total 1060
Authors Title Published Journal PubMed Link
Amorós I et al. Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner. 2010 J. Mol. Cell. Cardiol. pmid:19616555
Frampton G et al. Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling. 2010 Exp. Cell Res. pmid:20347808
Kim J and Alger BE Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. 2010 Nat. Neurosci. pmid:20348918
Hoot MR et al. Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. 2010 Brain Res. pmid:20380816
Caraceni P et al. Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. 2010 Liver Int. pmid:19840245
Piccinetti CC et al. Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. 2010 Gen. Comp. Endocrinol. pmid:19800340
Banni S and Di Marzo V Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood. 2010 Mol Nutr Food Res pmid:20013888
Romigi A et al. Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. 2010 Epilepsia pmid:19817812
Lerner TN et al. Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. 2010 J. Neurosci. pmid:20147543
Reggio PH Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. 2010 Curr. Med. Chem. pmid:20166921
Weis F et al. Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure. 2010 J. Mol. Cell. Cardiol. pmid:19931541
Sang N et al. Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway. 2010 Neurochem. Int. pmid:20064571
Jyotaki M et al. Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors. 2010 Endocr. J. pmid:20431269
Mukhopadhyay B et al. Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. 2010 J. Biol. Chem. pmid:20410309
Maccarrone M Endocannabinoid-binding receptors: old friends and new comers. 2010 Curr. Med. Chem. pmid:20441559
Skonberg C et al. Pitfalls in the sample preparation and analysis of N-acylethanolamines. 2010 J. Lipid Res. pmid:20447930
Fino E et al. Distinct coincidence detectors govern the corticostriatal spike timing-dependent plasticity. 2010 J. Physiol. (Lond.) pmid:20603333
Keown OP et al. 2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors. 2010 Br J Clin Pharmacol pmid:20653671
Ho WS et al. Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex. 2010 Br. J. Pharmacol. pmid:20590576
Breunig E et al. The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. 2010 J. Neurosci. pmid:20592217
Frazier CJ Key questions of endocannabinoid signalling in the CNS: which, where and when? 2011 J. Physiol. (Lond.) pmid:22001725
Nomura DK et al. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. 2011 Science pmid:22021672
Muppidi JR et al. Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. 2011 J. Exp. Med. pmid:21875957
Duggan KC et al. (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. 2011 Nat. Chem. Biol. pmid:22053353
Du H et al. Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. 2011 Br. J. Pharmacol. pmid:21501147
Raman P et al. 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. 2011 Mol. Pharmacol. pmid:21511917
Hofmann ME et al. Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. 2011 J. Physiol. (Lond.) pmid:21646412
Martín-Couce L et al. Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors. 2011 J. Med. Chem. pmid:21675776
Busquets-Garcia A et al. Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. 2011 Biol. Psychiatry pmid:21684528
Sarmad S et al. Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. 2011 J. Neurochem. pmid:21375532
Howlett AC et al. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. 2011 Br. J. Pharmacol. pmid:21545414
Carr RL et al. Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. 2011 Toxicol. Sci. pmid:21507991
Chiba T et al. A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. 2011 J. Pharm. Pharmacol. pmid:21492165
Vecchio AJ and Malkowski MG The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. 2011 J. Biol. Chem. pmid:21489986
Balenga NA et al. GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. 2011 Cell Res. pmid:21467997
Chen X et al. Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults. 2011 Neuroscience pmid:21256197
Yoshida T et al. Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21282604
Liao HT et al. Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition. 2011 Br. J. Pharmacol. pmid:21232043
Soderstrom K et al. Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness. 2011 BMC Neurosci pmid:21211022
De Petrocellis L et al. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. 2011 Br. J. Pharmacol. pmid:21175579
Petrosino S et al. Alteration of the endocannabinoid system in mouse brain during prion disease. 2011 Neuroscience pmid:21195746
Jumpertz R et al. Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. 2011 J. Clin. Endocrinol. Metab. pmid:21177788
Sciolino NR et al. Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. 2011 Pharmacol. Res. pmid:21600985
Guindon J et al. Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. 2011 Br. J. Pharmacol. pmid:21198549
Shekhar C Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. 2011 Chem. Biol. pmid:21609833
Brizzi A et al. Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor. 2011 J. Med. Chem. pmid:22044209
Yoshino H et al. Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. 2011 J. Physiol. (Lond.) pmid:21807615
Chouinard F et al. The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis. 2011 J. Immunol. pmid:21278347
Khasabova IA et al. Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. 2011 Pharmacol. Res. pmid:21440630
Catanzaro G et al. Effect of capacitation on the endocannabinoid system of mouse sperm. 2011 Mol. Cell. Endocrinol. pmid:21723369