2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cristino L et al. | Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency. | 2016 | Neuropsychopharmacology | pmid:26081302 |
Morena M et al. | Neurobiological Interactions Between Stress and the Endocannabinoid System. | 2016 | Neuropsychopharmacology | pmid:26068727 |
La Porta C et al. | Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain. | 2015 | Pain | pmid:26067584 |
Ma L et al. | Involvement of cannabinoid receptors in infrasonic noise-induced neuronal impairment. | 2015 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:26058582 |
Hutch CR et al. | An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction. | 2015 | Neuroscience | pmid:26037800 |
Dotsey EY et al. | Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. | 2015 | Chem. Biol. | pmid:26000748 |
Chicca A et al. | 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. | 2015 | J Neuroinflammation | pmid:25962384 |
Juan CC et al. | Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome. | 2015 | Fertil. Steril. | pmid:25935491 |
Vázquez C et al. | Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies. | 2015 | Neurobiol. Dis. | pmid:25917763 |
Jokisch V et al. | Endocannabinoid Levels in Newborns in Relation to the Mode of Delivery. | 2015 | Am J Perinatol | pmid:25915139 |
Manduca A et al. | Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. | 2015 | Eur Neuropsychopharmacol | pmid:25914159 |
Alizadeh A et al. | Role of cannabinoidergic system on food intake in neonatal layer-type chicken. | 2015 | Vet. Res. Commun. | pmid:25902906 |
Gomez O et al. | A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways. | 2015 | J Neuroimmune Pharmacol | pmid:25900077 |
Shimizu T et al. | Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat. | 2015 | Neuropharmacology | pmid:25882827 |
Turcotte C et al. | Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites. | 2015 | J. Leukoc. Biol. | pmid:25877930 |
Spaziano G et al. | Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. | 2015 | Biomed Res Int | pmid:25866824 |
Gong Y et al. | Simultaneous determination of endocannabinoids in murine plasma and brain substructures by surrogate-based LC-MS/MS: Application in tumor-bearing mice. | 2015 | J Pharm Biomed Anal | pmid:25863017 |
Subbanna S et al. | Postnatal ethanol exposure alters levels of 2-arachidonylglycerol-metabolizing enzymes and pharmacological inhibition of monoacylglycerol lipase does not cause neurodegeneration in neonatal mice. | 2015 | J. Neurochem. | pmid:25857698 |
Nicholson J et al. | Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. | 2015 | PLoS ONE | pmid:25835291 |
Liu Z et al. | Involvement of GluR2 up-regulation in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptor in mice. | 2015 | Sci Rep | pmid:25830356 |