2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Zou Z et al. | Endocannabinoid 2-Arachidonoylglycerol Suppresses LPS-Induced Inhibition of A-Type Potassium Channel Currents in Caudate Nucleus Neurons Through CB1 Receptor. | 2016 | J. Mol. Neurosci. | pmid:27129498 |
Keyshams N et al. | Cannabinoid-glutamate interactions in the regulation of food intake in neonatal layer- type chicks: role of glutamate NMDA and AMPA receptors. | 2016 | Vet. Res. Commun. | pmid:27000110 |
Feliszek M et al. | Lack of hippocampal CB1 receptor desensitization by Δ(9)-tetrahydrocannabinol in aged mice and by low doses of JZL 184. | 2016 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:26984820 |
Zhang L et al. | Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons. | 2016 | Neuroscience | pmid:26924019 |
Wang X et al. | Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. | 2016 | Biomed Res Int | pmid:26904688 |
González-Mariscal I et al. | Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. | 2016 | Mol. Cell. Endocrinol. | pmid:26724516 |
Wills KL et al. | Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats. | 2016 | Neuropsychopharmacology | pmid:26647976 |
Gobira PH et al. | Role of the endocannabinoid 2-arachidonoylglycerol in aversive responses mediated by the dorsolateral periaqueductal grey. | 2016 | Eur Neuropsychopharmacol | pmid:26628106 |
Lu HC and Mackie K | An Introduction to the Endogenous Cannabinoid System. | 2016 | Biol. Psychiatry | pmid:26698193 |
Signorello MG and Leoncini G | Regulation of cAMP Intracellular Levels in Human Platelets Stimulated by 2-Arachidonoylglycerol. | 2016 | J. Cell. Biochem. | pmid:26460717 |
Wang F et al. | 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation. | 2016 | Rejuvenation Res | pmid:26414218 |
Sanchez AM et al. | Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis. | 2016 | Reprod Sci | pmid:26887427 |
Morena M et al. | Neurobiological Interactions Between Stress and the Endocannabinoid System. | 2016 | Neuropsychopharmacology | pmid:26068727 |
Knani I et al. | Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome. | 2016 | Mol Metab | pmid:27900261 |
Liu X et al. | Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase. | 2016 | Sci Rep | pmid:27775008 |
Tung LW et al. | Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. | 2016 | Nat Commun | pmid:27448020 |
Patel S et al. | The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models. | 2016 | Biol. Psychiatry | pmid:26212898 |
Kudalkar SN et al. | Assay of Endocannabinoid Oxidation by Cyclooxygenase-2. | 2016 | Methods Mol. Biol. | pmid:27245906 |
Jung KM and Piomelli D | Assay of Monoacylglycerol Lipase Activity. | 2016 | Methods Mol. Biol. | pmid:27245902 |
Reddy IA et al. | Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. | 2016 | Transl Psychiatry | pmid:27187231 |
Gray JM et al. | Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. | 2016 | Psychoneuroendocrinology | pmid:26821211 |
Artegoitia VM et al. | Endocannabinoids concentrations in plasma associated with feed efficiency and carcass composition of beef steers. | 2016 | J. Anim. Sci. | pmid:28046144 |
Morena M et al. | Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. | 2016 | Neuropharmacology | pmid:27553121 |
Veeraraghavan P et al. | A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro. | 2016 | Neuroscience | pmid:27450568 |
van Zadelhoff G and van der Stelt M | Oxygenation of Anandamide by Lipoxygenases. | 2016 | Methods Mol. Biol. | pmid:27245907 |
Martella A et al. | Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop. | 2016 | Endocrinology | pmid:27014939 |
Iannotti FA et al. | Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders. | 2016 | Prog. Lipid Res. | pmid:26965148 |
Yang W et al. | Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells. | 2016 | Neuroscience | pmid:26621126 |
Sustkova-Fiserova M et al. | Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens. | 2016 | Psychopharmacology (Berl.) | pmid:26507196 |
Leishman E et al. | Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. | 2016 | Pharmacol. Res. | pmid:27109320 |
Rajaraman G et al. | G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction. | 2016 | Mol Nutr Food Res | pmid:26337420 |
Leishman E et al. | Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain. | 2016 | Biochim. Biophys. Acta | pmid:26956082 |
Petrosino S et al. | The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels. | 2016 | Br. J. Pharmacol. | pmid:25598150 |
Di S et al. | Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. | 2016 | J. Neurosci. | pmid:27511017 |
Aaltonen N et al. | In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048). | 2016 | J. Pharmacol. Exp. Ther. | pmid:27451409 |
Sharkey KA and Wiley JW | The Role of the Endocannabinoid System in the Brain-Gut Axis. | 2016 | Gastroenterology | pmid:27133395 |
Yan W et al. | NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication. | 2016 | Sci Rep | pmid:26928013 |
Hartley ND et al. | 2-arachidonoylglycerol signaling impairs short-term fear extinction. | 2016 | Transl Psychiatry | pmid:26926885 |
Brindisi M et al. | Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. | 2016 | J. Med. Chem. | pmid:26888301 |
Tegeder I | Endocannabinoids as Guardians of Metastasis. | 2016 | Int J Mol Sci | pmid:26875980 |
Pastor A et al. | A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women. | 2016 | PLoS ONE | pmid:26849214 |
Wilkerson JL et al. | The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. | 2016 | J. Pharmacol. Exp. Ther. | pmid:26791602 |
Aso C et al. | Protein purification and cloning of diacylglycerol lipase from rat brain. | 2016 | J. Biochem. | pmid:26790472 |
Buczynski MW et al. | Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26755579 |
Ogasawara D et al. | Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26668358 |
Hanlon EC et al. | Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. | 2016 | Sleep | pmid:26612385 |
Vujic N et al. | Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice. | 2016 | Atherosclerosis | pmid:26584135 |
Mann A et al. | Are the endocannabinoid-like compounds N-acyl aminoacids neuroprotective after traumatic brain injury? | 2016 | J Basic Clin Physiol Pharmacol | pmid:26565551 |
Grabner GF et al. | Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation. | 2016 | J. Biol. Chem. | pmid:26565024 |
Matthews AT et al. | Oxyradical stress increases the biosynthesis of 2-arachidonoylglycerol: involvement of NADPH oxidase. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:27784678 |
Sticht MA et al. | Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex. | 2016 | Neuropharmacology | pmid:26541329 |
McReynolds JR et al. | CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. | 2016 | Psychopharmacology (Berl.) | pmid:26455361 |
Stark DT and Caprioli J | Subcellular Localization of a 2-Arachidonoyl Glycerol Signaling Cassette in Retinal Ganglion Cell Axonal Growth In Vitro. | 2016 | Invest. Ophthalmol. Vis. Sci. | pmid:28002563 |
Wang X et al. | Endogenous cannabinoid system alterations and their role in epileptogenesis after brain injury in rat. | 2016 | Epilepsy Res. | pmid:27810514 |
Volk DW and Lewis DA | The Role of Endocannabinoid Signaling in Cortical Inhibitory Neuron Dysfunction in Schizophrenia. | 2016 | Biol. Psychiatry | pmid:26210060 |
Araki M et al. | Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase. | 2016 | J. Biochem. | pmid:27198176 |
Fisette A et al. | α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. | 2016 | Cell Rep | pmid:27783937 |
Sugaya Y et al. | Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures. | 2016 | Cell Rep | pmid:27452464 |
Bosch-Bouju C et al. | Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress. | 2016 | Cell Rep | pmid:27452462 |
Cristino L et al. | Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency. | 2016 | Neuropsychopharmacology | pmid:26081302 |
Imperatore R et al. | Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation. | 2016 | Pharmacol. Res. | pmid:27436148 |
Wiley JL et al. | Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice. | 2016 | Behav Pharmacol | pmid:27385208 |
Janssen FJ and van der Stelt M | Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. | 2016 | Bioorg. Med. Chem. Lett. | pmid:27394666 |
Mwanza C et al. | Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27318292 |
Bisogno T | Assay of DAGLα/β Activity. | 2016 | Methods Mol. Biol. | pmid:27245901 |
Battista N and Sergi M | Determination of 2-Arachidonoylglycerol by μSPE-LC-MS/MS. | 2016 | Methods Mol. Biol. | pmid:27245888 |
Liisberg U et al. | Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice. | 2016 | J. Nutr. Biochem. | pmid:27155918 |
Bashashati M et al. | Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation. | 2015 | Br. J. Pharmacol. | pmid:25684407 |
Schaich CL et al. | Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. | 2015 | J. Cardiovasc. Pharmacol. | pmid:25636077 |
Belluomo I et al. | Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes. | 2015 | J. Neurochem. | pmid:25626460 |
Brosnihan KB et al. | Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. | 2015 | Reprod. Biol. Endocrinol. | pmid:25596750 |
Griebel G et al. | Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. | 2015 | Sci Rep | pmid:25560837 |
Zhang J et al. | Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. | 2015 | J. Cereb. Blood Flow Metab. | pmid:25492114 |
Marcaggi P | Cerebellar endocannabinoids: retrograde signaling from purkinje cells. | 2015 | Cerebellum | pmid:25520276 |
Szekeres M et al. | Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension. | 2015 | Mol. Cell. Endocrinol. | pmid:25595485 |
Li B et al. | Endogenous 2-Arachidonoylglycerol Alleviates Cyclooxygenases-2 Elevation-Mediated Neuronal Injury From SO2 Inhalation via PPARγ Pathway. | 2015 | Toxicol. Sci. | pmid:26209559 |
Ivanov I et al. | A simple method for simultaneous determination of N-arachidonoylethanolamine, N-oleoylethanolamine, N-palmitoylethanolamine and 2-arachidonoylglycerol in human cells. | 2015 | Anal Bioanal Chem | pmid:25519724 |
Walentiny DM et al. | Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice. | 2015 | Neuropharmacology | pmid:25698527 |
Monteleone AM et al. | Deranged endocannabinoid responses to hedonic eating in underweight and recently weight-restored patients with anorexia nervosa. | 2015 | Am. J. Clin. Nutr. | pmid:25646322 |
Gaskari SA et al. | Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids. | 2015 | J. Hepatol. | pmid:25640062 |
Scotchie JG et al. | Endocannabinoid regulation in human endometrium across the menstrual cycle. | 2015 | Reprod Sci | pmid:24819878 |
Pasquarelli N et al. | Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue. | 2015 | Neuropharmacology | pmid:25497453 |
Pisanti S et al. | Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. | 2015 | J. Cell. Physiol. | pmid:25684344 |
Aliczki M et al. | Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. | 2015 | Psychopharmacology (Berl.) | pmid:25547462 |
Urquhart P et al. | Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases. | 2015 | Biochim. Biophys. Acta | pmid:25543004 |
Liu J et al. | Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum. | 2015 | Neurotoxicology | pmid:26215119 |
Ford GK et al. | Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. | 2015 | Eur J Pain | pmid:25504741 |
Sticht MA et al. | Intra-visceral insular cortex 2-arachidonoylglycerol, but not N-arachidonoylethanolamide, suppresses acute nausea-induced conditioned gaping in rats. | 2015 | Neuroscience | pmid:25499318 |
Orellana-Serradell O et al. | Proapoptotic effect of endocannabinoids in prostate cancer cells. | 2015 | Oncol. Rep. | pmid:25606819 |
Pacioni G et al. | Truffles contain endocannabinoid metabolic enzymes and anandamide. | 2015 | Phytochemistry | pmid:25433633 |
Wollank Y et al. | Inhibition of FAAH confers increased stem cell migration via PPARα. | 2015 | J. Lipid Res. | pmid:26263913 |
Mitchener MM et al. | Competition and allostery govern substrate selectivity of cyclooxygenase-2. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26392530 |
Wang H et al. | Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. | 2015 | Cell Rep | pmid:26365195 |
Ho WS et al. | Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol. | 2015 | Br. J. Pharmacol. | pmid:26294342 |
DiPatrizio NV et al. | Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. | 2015 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:26290104 |
Mounsey RB et al. | Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. | 2015 | Exp. Neurol. | pmid:26244281 |
Guggenhuber S et al. | Impaired 2-AG Signaling in Hippocampal Glutamatergic Neurons: Aggravation of Anxiety-Like Behavior and Unaltered Seizure Susceptibility. | 2015 | Int. J. Neuropsychopharmacol. | pmid:26232789 |
Imperatore R et al. | Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CBâ‚R signaling and anxiety-like behavior. | 2015 | J. Neurochem. | pmid:26223500 |
Anderson GR et al. | β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. | 2015 | Cell | pmid:26213384 |
Viader A et al. | Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. | 2015 | Cell Rep | pmid:26212325 |