2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Alzheimer Disease D000544 76 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Body Weight D001835 333 associated lipids
Brain Concussion D001924 5 associated lipids
Brain Edema D001929 20 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Catalepsy D002375 30 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Encephalitis D004660 15 associated lipids
Epilepsy D004827 35 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Glioma D005910 112 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Hyperalgesia D006930 42 associated lipids
Hyperinsulinism D006946 27 associated lipids
Hyperkinesis D006948 11 associated lipids
Hypotension D007022 41 associated lipids
Hypothermia D007035 19 associated lipids
Inflammation D007249 119 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Memory Disorders D008569 33 associated lipids
Morphine Dependence D009021 9 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neuralgia D009437 28 associated lipids
Neuromyelitis Optica D009471 2 associated lipids
Obesity D009765 29 associated lipids
Pain D010146 64 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Starvation D013217 47 associated lipids
Stomach Ulcer D013276 75 associated lipids
Reperfusion Injury D015427 65 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Weight Gain D015430 101 associated lipids
Head Injuries, Closed D016489 5 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Ganglion Cysts D045888 1 associated lipids
Fetal Nutrition Disorders D048070 1 associated lipids
Acute Lung Injury D055371 33 associated lipids
Acute Pain D059787 3 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

Download all related citations
Per page 10 20 50 100 | Total 1060
Authors Title Published Journal PubMed Link
Marco EM and Viveros MP The critical role of the endocannabinoid system in emotional homeostasis: avoiding excess and deficiencies. 2009 Mini Rev Med Chem pmid:19929814
Katona I Endocannabinoid receptors: CNS localization of the CB₁ cannabinoid receptor. 2009 Curr Top Behav Neurosci pmid:21104380
Sun X and Dey SK Cannabinoid/Endocannabinoid signaling impact on early pregnancy events. 2009 Curr Top Behav Neurosci pmid:21104387
Alvarez-Jaimes L et al. Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats. 2009 J. Neurochem. pmid:19650871
Maccarrone M et al. Lipid rafts regulate 2-arachidonoylglycerol metabolism and physiological activity in the striatum. 2009 J. Neurochem. pmid:19187444
Bisogno T et al. Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. 2009 ChemMedChem pmid:19266526
Kreutz S et al. 2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal-cannabidiol-sensitive receptors on microglial cells. 2009 Glia pmid:18837048
Di Marzo V et al. Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors. 2009 Diabetologia pmid:18972095
Avraham Y et al. Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice. 2009 Br. J. Pharmacol. pmid:19764982
Straiker A et al. Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. 2009 Mol. Pharmacol. pmid:19767452
Bisogno T et al. Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. 2009 Biochim. Biophys. Acta pmid:19027877
Long JZ et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. 2009 Nat. Chem. Biol. pmid:19029917
Koppel J et al. Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study. 2009 Lipids Health Dis pmid:19144193
Won YJ et al. Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons. 2009 J. Neurosci. pmid:19864572
Maison P et al. BDNF regulates neuronal sensitivity to endocannabinoids. 2009 Neurosci. Lett. pmid:19818836
Gkini E et al. Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase. 2009 Platelets pmid:19811221
Avraham Y et al. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the evolution of experimental cholestatic liver disease. 2008 Jul-Aug Prostaglandins Leukot. Essent. Fatty Acids pmid:18771906
Llorente R et al. Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system. 2008 Dev Neurobiol pmid:18666205
Nomura DK et al. Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. 2008 Bioorg. Med. Chem. Lett. pmid:18752948
DiPatrizio NV and Simansky KJ Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats. 2008 J. Neurosci. pmid:18815256
Baldassarri S et al. The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors. 2008 J. Thromb. Haemost. pmid:18647220
Ortar G et al. Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. 2008 Eur J Med Chem pmid:17452063
Shiratsuchi A et al. Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis. 2008 Immunol. Cell Biol. pmid:17909562
Duan Y et al. Inhibition of [3H]batrachotoxinin A-20alpha-benzoate binding to sodium channels and sodium channel function by endocannabinoids. 2008 Neurochem. Int. pmid:17888543
Rimmerman N et al. Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line. 2008 Br. J. Pharmacol. pmid:17965731
Vellani V et al. Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin. 2008 Neuropharmacology pmid:18329052
Guindon J and Hohmann AG A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism. 2008 Br. J. Pharmacol. pmid:18297102
Hu SS et al. Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity. 2008 Br. J. Pharmacol. pmid:18297109
Friedman SL and Nieto N Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors. 2008 Cell Metab. pmid:18316020
Jeong WI et al. Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. 2008 Cell Metab. pmid:18316028
Ortar G et al. Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. 2008 J. Med. Chem. pmid:18831576
Palmer JA et al. Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. 2008 Neuroscience pmid:18541380
Hoover HS et al. Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. 2008 Bioorg. Med. Chem. Lett. pmid:18657971
Pertwee RG Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. 2008 Addict Biol pmid:18482430
Di Filippo M et al. Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. 2008 J. Neurol. Neurosurg. Psychiatr. pmid:18535023
Hill MN et al. Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. 2008 J Neural Transm pmid:18974922
Ellgren M et al. Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. 2008 Eur Neuropsychopharmacol pmid:18674887
Fowler CJ and Ghafouri N Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? 2008 Pharmacol. Res. pmid:18675915
Fowler CJ "The tools of the trade"--an overview of the pharmacology of the endocannabinoid system. 2008 Curr. Pharm. Des. pmid:18781976
Placzek EA et al. Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. 2008 J. Neurochem. pmid:18778304
Placzek EA et al. Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. 2008 Neuropharmacology pmid:18760289
Lehtonen M et al. Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes. 2008 Chem. Biodivers. pmid:19035572
Sheinin A et al. Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. 2008 J. Neurophysiol. pmid:18497350
Zhang J and Chen C Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. 2008 J. Biol. Chem. pmid:18534982
Nabemoto M et al. Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha. 2008 Eur. J. Pharmacol. pmid:18539271
Endsley MP et al. Expression and function of fatty acid amide hydrolase in prostate cancer. 2008 Int. J. Cancer pmid:18566995
Rockwell CE et al. A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells. 2008 Biochem. Pharmacol. pmid:18571623
Njie YF et al. Aqueous humor outflow effects of 2-arachidonylglycerol. 2008 Exp. Eye Res. pmid:18597752
Motaghedi R and McGraw TE The CB1 endocannabinoid system modulates adipocyte insulin sensitivity. 2008 Obesity (Silver Spring) pmid:18551116
Burston JJ et al. N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. 2008 J. Pharmacol. Exp. Ther. pmid:18682568