2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Guida M et al. | The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma. | 2010 | Endocrinology | pmid:20133454 |
Nithipatikom K et al. | Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells. | 2012 | Endocrinology | pmid:22087025 |
Forner-Piquer I et al. | Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish. | 2017 | Endocrinology | pmid:28938452 |
Martella A et al. | Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop. | 2016 | Endocrinology | pmid:27014939 |
Chen Y et al. | Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum. | 2016 May-Jun | eNeuro | pmid:27182552 |
Forner-Piquer I et al. | Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. | 2018 | Environ. Pollut. | pmid:29793103 |
Romigi A et al. | Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. | 2010 | Epilepsia | pmid:19817812 |
Wang X et al. | Endogenous cannabinoid system alterations and their role in epileptogenesis after brain injury in rat. | 2016 | Epilepsy Res. | pmid:27810514 |
Kranaster L et al. | Electroconvulsive therapy enhances endocannabinoids in the cerebrospinal fluid of patients with major depression: a preliminary prospective study. | 2017 | Eur Arch Psychiatry Clin Neurosci | pmid:28342110 |
Schaefer C et al. | Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders. | 2014 | Eur Arch Psychiatry Clin Neurosci | pmid:24253425 |
Ortar G et al. | Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. | 2008 | Eur J Med Chem | pmid:17452063 |
Monteleone AM et al. | Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity. | 2016 | Eur J Nutr | pmid:26759262 |
Ford GK et al. | Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. | 2015 | Eur J Pain | pmid:25504741 |
Matuszak N et al. | Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth. | 2012 | Eur J Pharm Sci | pmid:22127371 |
Aaltonen N et al. | Brain regional cannabinoid CB(1) receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice. | 2014 | Eur J Pharm Sci | pmid:24012970 |
Gobira PH et al. | Role of the endocannabinoid 2-arachidonoylglycerol in aversive responses mediated by the dorsolateral periaqueductal grey. | 2016 | Eur Neuropsychopharmacol | pmid:26628106 |
McLaughlin RJ et al. | Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. | 2012 | Eur Neuropsychopharmacol | pmid:22325231 |
Manduca A et al. | Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. | 2015 | Eur Neuropsychopharmacol | pmid:25914159 |
Ellgren M et al. | Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. | 2008 | Eur Neuropsychopharmacol | pmid:18674887 |
Quercioli A et al. | Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. | 2011 | Eur. Heart J. | pmid:21303779 |