2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wang X et al. | Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. | 2016 | Biomed Res Int | pmid:26904688 |
Wills KL et al. | Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats. | 2016 | Neuropsychopharmacology | pmid:26647976 |
Gobira PH et al. | Role of the endocannabinoid 2-arachidonoylglycerol in aversive responses mediated by the dorsolateral periaqueductal grey. | 2016 | Eur Neuropsychopharmacol | pmid:26628106 |
Signorello MG and Leoncini G | Regulation of cAMP Intracellular Levels in Human Platelets Stimulated by 2-Arachidonoylglycerol. | 2016 | J. Cell. Biochem. | pmid:26460717 |
Wang F et al. | 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation. | 2016 | Rejuvenation Res | pmid:26414218 |
Morena M et al. | Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. | 2016 | Neuropharmacology | pmid:27553121 |
Yang W et al. | Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells. | 2016 | Neuroscience | pmid:26621126 |
Sustkova-Fiserova M et al. | Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens. | 2016 | Psychopharmacology (Berl.) | pmid:26507196 |
Petrosino S et al. | The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels. | 2016 | Br. J. Pharmacol. | pmid:25598150 |
Yan W et al. | NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication. | 2016 | Sci Rep | pmid:26928013 |
Hartley ND et al. | 2-arachidonoylglycerol signaling impairs short-term fear extinction. | 2016 | Transl Psychiatry | pmid:26926885 |
Brindisi M et al. | Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. | 2016 | J. Med. Chem. | pmid:26888301 |
Tegeder I | Endocannabinoids as Guardians of Metastasis. | 2016 | Int J Mol Sci | pmid:26875980 |
Matthews AT et al. | Oxyradical stress increases the biosynthesis of 2-arachidonoylglycerol: involvement of NADPH oxidase. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:27784678 |
Araki M et al. | Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase. | 2016 | J. Biochem. | pmid:27198176 |
Fisette A et al. | α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. | 2016 | Cell Rep | pmid:27783937 |
Sugaya Y et al. | Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures. | 2016 | Cell Rep | pmid:27452464 |
Shonesy BC et al. | The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. | 2015 | Neuropharmacology | pmid:25484252 |
Martins CJ et al. | Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. | 2015 | PLoS ONE | pmid:26561012 |
Hanlon EC et al. | Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol. | 2015 | J. Clin. Endocrinol. Metab. | pmid:25368979 |
Petrenko AB et al. | Genetic inactivation and prolonged pharmacologic inhibition of monoacylglycerol lipase have opposite effects on anesthetic sensitivity to propofol. | 2015 | Eur. J. Pharmacol. | pmid:26318148 |
Zou Z et al. | Effect of Homocysteine on Voltage-Gated Sodium Channel Currents in Primary Cultured Rat Caudate Nucleus Neurons and Its Modulation by 2-Arachidonylglycerol. | 2015 | J. Mol. Neurosci. | pmid:26179279 |
GarcÃa del Caño G et al. | Nuclear diacylglycerol lipase-α in rat brain cortical neurons: evidence of 2-arachidonoylglycerol production in concert with phospholipase C-β activity. | 2015 | J. Neurochem. | pmid:25308538 |
Ma L et al. | Involvement of cannabinoid receptors in infrasonic noise-induced neuronal impairment. | 2015 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:26058582 |
Katz PS et al. | Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury. | 2015 | J. Neurotrauma | pmid:25166905 |
Alizadeh A et al. | Role of cannabinoidergic system on food intake in neonatal layer-type chicken. | 2015 | Vet. Res. Commun. | pmid:25902906 |
Gomez O et al. | A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways. | 2015 | J Neuroimmune Pharmacol | pmid:25900077 |
Mennella I et al. | Food Liking Enhances the Plasma Response of 2-Arachidonoylglycerol and of Pancreatic Polypeptide upon Modified Sham Feeding in Humans. | 2015 | J. Nutr. | pmid:26180248 |
Dong M et al. | Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against homocysteine-induced impairments in rat caudate nucleus through CB1 receptor. | 2015 | J. Mol. Neurosci. | pmid:25007951 |
Turcotte C et al. | Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites. | 2015 | J. Leukoc. Biol. | pmid:25877930 |
Spaziano G et al. | Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. | 2015 | Biomed Res Int | pmid:25866824 |
Qi M et al. | A robust capillary liquid chromatography/tandem mass spectrometry method for quantitation of neuromodulatory endocannabinoids. | 2015 | Rapid Commun. Mass Spectrom. | pmid:26411510 |
Cascio MG and Marini P | Biosynthesis and Fate of Endocannabinoids. | 2015 | Handb Exp Pharmacol | pmid:26408157 |
Piyanova A et al. | Age-related changes in the endocannabinoid system in the mouse hippocampus. | 2015 | Mech. Ageing Dev. | pmid:26278494 |
Mecha M et al. | Endocannabinoids drive the acquisition of an alternative phenotype in microglia. | 2015 | Brain Behav. Immun. | pmid:26086345 |
Juan CC et al. | Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome. | 2015 | Fertil. Steril. | pmid:25935491 |
Vázquez C et al. | Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies. | 2015 | Neurobiol. Dis. | pmid:25917763 |
Jokisch V et al. | Endocannabinoid Levels in Newborns in Relation to the Mode of Delivery. | 2015 | Am J Perinatol | pmid:25915139 |
Manduca A et al. | Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. | 2015 | Eur Neuropsychopharmacol | pmid:25914159 |
Alhouayek M et al. | N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis. | 2015 | FASEB J. | pmid:25384424 |
Park SW et al. | Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species. | 2015 | Head Neck | pmid:24797795 |
Checa A et al. | Lipid mediator profile in vernix caseosa reflects skin barrier development. | 2015 | Sci Rep | pmid:26521946 |
Straiker A et al. | Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model. | 2015 | Pharmacol. Res. | pmid:26211948 |
Kita Y et al. | Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2. | 2015 | PLoS ONE | pmid:26196692 |
Lee SH et al. | Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release. | 2015 | J. Neurosci. | pmid:26157003 |
Parker KE et al. | Effects of co-administration of 2-arachidonylglycerol (2-AG) and a selective µ-opioid receptor agonist into the nucleus accumbens on high-fat feeding behaviors in the rat. | 2015 | Brain Res. | pmid:26100333 |
La Porta C et al. | Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain. | 2015 | Pain | pmid:26067584 |
Hutch CR et al. | An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction. | 2015 | Neuroscience | pmid:26037800 |
Dotsey EY et al. | Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. | 2015 | Chem. Biol. | pmid:26000748 |
Chicca A et al. | 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. | 2015 | J Neuroinflammation | pmid:25962384 |