2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Jordà MA et al. | The peripheral cannabinoid receptor Cb2, a novel oncoprotein, induces a reversible block in neutrophilic differentiation. | 2003 | Blood | pmid:12406867 |
Viganò D et al. | Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain. | 2003 | Neuropsychopharmacology | pmid:12637958 |
Oka S et al. | Ether-linked analogue of 2-arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species. | 2003 | J. Neurochem. | pmid:12787057 |
Jorda MA et al. | Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12799277 |
Walter L and Stella N | Endothelin-1 increases 2-arachidonoyl glycerol (2-AG) production in astrocytes. | 2003 | Glia | pmid:12951660 |
Wallace MJ et al. | The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12954810 |
Vannacci A et al. | Nitric oxide modulates the inhibitory effect of cannabinoids on the immunological activation of guinea pig mast cells. | 2003 | Inflamm. Res. | pmid:12755386 |
Kishimoto S et al. | 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. | 2003 | J. Biol. Chem. | pmid:12711605 |
Maccarrone M et al. | Activation of human platelets by 2-arachidonoylglycerol is enhanced by serotonin. | 2003 | Thromb. Haemost. | pmid:12574815 |
Fowler CJ et al. | Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. | 2003 | Biochem. Pharmacol. | pmid:12948856 |
Obata T et al. | Simultaneous determination of endocannabinoids (arachidonylethanolamide and 2-arachidonylglycerol) and isoprostane (8-epiprostaglandin F2alpha) by gas chromatography-mass spectrometry-selected ion monitoring for medical samples. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12829006 |
Maccarrone M et al. | Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. | 2003 | J. Biol. Chem. | pmid:12799380 |
Derkinderen P et al. | Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. | 2003 | J. Neurosci. | pmid:12657697 |
Maccarrone M et al. | Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. | 2003 | J. Neurochem. | pmid:12716433 |
Bouchard JF et al. | Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart. | 2003 | Life Sci. | pmid:12586223 |
McCarron RM et al. | Antioxidant properties of the vasoactive endocannabinoid, 2-arachidonoyl glycerol (2-AG). | 2003 | Acta Neurochir. Suppl. | pmid:14753451 |
Higgs S et al. | Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. | 2003 | Psychopharmacology (Berl.) | pmid:12447606 |
Bisogno T et al. | Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. | 2003 | J. Cell Biol. | pmid:14610053 |
Facchinetti F et al. | Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide. | 2003 | Glia | pmid:12509806 |
Mechoulam R and Lichtman AH | Neuroscience. Stout guards of the central nervous system. | 2003 | Science | pmid:14526067 |