2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Suhara Y et al. | Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues. | 2000 | Chem. Pharm. Bull. | pmid:10923815 |
Di Marzo V et al. | Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease. | 2000 | FASEB J. | pmid:10877836 |
Hillard CJ | Endocannabinoids and vascular function. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10871291 |
Jarrahian A et al. | Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter. | 2000 | J. Neurochem. | pmid:10820223 |
Sugiura T and Waku K | 2-arachidonoylglycerol: a possible multifunctional lipid mediator in the nervous and immune systems. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818479 |
Beltramo M and Piomelli D | Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol. | 2000 | Neuroreport | pmid:10817598 |
Sugiura T et al. | Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10814517 |
Kunos G et al. | Cardiovascular effects of endocannabinoids--the plot thickens. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785543 |
Di Marzo V et al. | Cannabimimetic fatty acid derivatives in cancer and inflammation. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785541 |
Hillard CJ | Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785538 |