2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Adermark L and Lovinger DM | Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077376 |
Cisneros JA et al. | Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. | 2007 | J. Med. Chem. | pmid:17764163 |
He F et al. | Involvement of the 90-kDa heat shock protein (Hsp-90) in CB2 cannabinoid receptor-mediated cell migration: a new role of Hsp-90 in migration signaling of a G protein-coupled receptor. | 2007 | Mol. Pharmacol. | pmid:17698952 |
Saario SM and Laitinen JT | Monoglyceride lipase as an enzyme hydrolyzing 2-arachidonoylglycerol. | 2007 | Chem. Biodivers. | pmid:17712832 |
Vadivel SK et al. | Conformationally constrained analogues of 2-arachidonoylglycerol. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17826996 |
Guindon J et al. | The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptors. | 2007 | Br. J. Pharmacol. | pmid:17179944 |
Scutt A and Williamson EM | Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. | 2007 | Calcif. Tissue Int. | pmid:17205329 |
Imming P | Fatty pain cures. | 2007 | Chem. Biol. | pmid:18096498 |
King AR et al. | URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. | 2007 | Chem. Biol. | pmid:18096504 |
Mukhopadhyay S and Tulis DA | Endocannabinoid regulation of matrix metalloproteinases: implications in ischemic stroke. | 2007 | Cardiovasc Hematol Agents Med Chem | pmid:17979695 |
Dainese E et al. | Modulation of the endocannabinoid system by lipid rafts. | 2007 | Curr. Med. Chem. | pmid:17979719 |
Fan SF and Yazulla S | Retrograde endocannabinoid inhibition of goldfish retinal cones is mediated by 2-arachidonoyl glycerol. | 2007 May-Jun | Vis. Neurosci. | pmid:17592669 |
Sakamoto Y et al. | Clinical responses and improvement of some laboratory parameters following polymyxin B-immobilized fiber treatment in septic shock. | 2007 Sep-Oct | ASAIO J. | pmid:17885340 |
Ortar G et al. | Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. | 2008 | Eur J Med Chem | pmid:17452063 |
Vellani V et al. | Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin. | 2008 | Neuropharmacology | pmid:18329052 |
Guindon J and Hohmann AG | A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism. | 2008 | Br. J. Pharmacol. | pmid:18297102 |
Hu SS et al. | Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity. | 2008 | Br. J. Pharmacol. | pmid:18297109 |
Friedman SL and Nieto N | Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors. | 2008 | Cell Metab. | pmid:18316020 |
Sheinin A et al. | Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. | 2008 | J. Neurophysiol. | pmid:18497350 |
Zhang J and Chen C | Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. | 2008 | J. Biol. Chem. | pmid:18534982 |