2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Midtbø LK et al. | Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice. | 2015 | J. Nutr. Biochem. | pmid:25776459 |
Niki M et al. | Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice. | 2015 | J. Physiol. (Lond.) | pmid:25728242 |
Bashashati M et al. | Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation. | 2015 | Br. J. Pharmacol. | pmid:25684407 |
Schaich CL et al. | Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. | 2015 | J. Cardiovasc. Pharmacol. | pmid:25636077 |
Belluomo I et al. | Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes. | 2015 | J. Neurochem. | pmid:25626460 |
Brosnihan KB et al. | Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. | 2015 | Reprod. Biol. Endocrinol. | pmid:25596750 |
Griebel G et al. | Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. | 2015 | Sci Rep | pmid:25560837 |
Zhang J et al. | Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. | 2015 | J. Cereb. Blood Flow Metab. | pmid:25492114 |
Shonesy BC et al. | The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. | 2015 | Neuropharmacology | pmid:25484252 |
Lecru L et al. | Cannabinoid receptor 1 is a major mediator of renal fibrosis. | 2015 | Kidney Int. | pmid:25760323 |
Mann A et al. | Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury. | 2015 | J Neuroimmune Pharmacol | pmid:25721934 |
Marcaggi P | Cerebellar endocannabinoids: retrograde signaling from purkinje cells. | 2015 | Cerebellum | pmid:25520276 |
Szekeres M et al. | Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension. | 2015 | Mol. Cell. Endocrinol. | pmid:25595485 |
Li B et al. | Endogenous 2-Arachidonoylglycerol Alleviates Cyclooxygenases-2 Elevation-Mediated Neuronal Injury From SO2 Inhalation via PPARγ Pathway. | 2015 | Toxicol. Sci. | pmid:26209559 |
Costa MA et al. | 2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental development. | 2015 | Mol. Cell. Endocrinol. | pmid:25199616 |
Ivanov I et al. | A simple method for simultaneous determination of N-arachidonoylethanolamine, N-oleoylethanolamine, N-palmitoylethanolamine and 2-arachidonoylglycerol in human cells. | 2015 | Anal Bioanal Chem | pmid:25519724 |
Walentiny DM et al. | Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice. | 2015 | Neuropharmacology | pmid:25698527 |
Monteleone AM et al. | Deranged endocannabinoid responses to hedonic eating in underweight and recently weight-restored patients with anorexia nervosa. | 2015 | Am. J. Clin. Nutr. | pmid:25646322 |
Gaskari SA et al. | Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids. | 2015 | J. Hepatol. | pmid:25640062 |
Scotchie JG et al. | Endocannabinoid regulation in human endometrium across the menstrual cycle. | 2015 | Reprod Sci | pmid:24819878 |
Pasquarelli N et al. | Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue. | 2015 | Neuropharmacology | pmid:25497453 |
Qi M et al. | A robust capillary liquid chromatography/tandem mass spectrometry method for quantitation of neuromodulatory endocannabinoids. | 2015 | Rapid Commun. Mass Spectrom. | pmid:26411510 |
Cascio MG and Marini P | Biosynthesis and Fate of Endocannabinoids. | 2015 | Handb Exp Pharmacol | pmid:26408157 |
Pisanti S et al. | Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. | 2015 | J. Cell. Physiol. | pmid:25684344 |
Aliczki M et al. | Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. | 2015 | Psychopharmacology (Berl.) | pmid:25547462 |
Urquhart P et al. | Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases. | 2015 | Biochim. Biophys. Acta | pmid:25543004 |
Liu J et al. | Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum. | 2015 | Neurotoxicology | pmid:26215119 |
Ford GK et al. | Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. | 2015 | Eur J Pain | pmid:25504741 |
Sticht MA et al. | Intra-visceral insular cortex 2-arachidonoylglycerol, but not N-arachidonoylethanolamide, suppresses acute nausea-induced conditioned gaping in rats. | 2015 | Neuroscience | pmid:25499318 |
Orellana-Serradell O et al. | Proapoptotic effect of endocannabinoids in prostate cancer cells. | 2015 | Oncol. Rep. | pmid:25606819 |
Pacioni G et al. | Truffles contain endocannabinoid metabolic enzymes and anandamide. | 2015 | Phytochemistry | pmid:25433633 |
Wollank Y et al. | Inhibition of FAAH confers increased stem cell migration via PPARα. | 2015 | J. Lipid Res. | pmid:26263913 |
Szafran B et al. | Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate inflammation. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26403860 |
Mitchener MM et al. | Competition and allostery govern substrate selectivity of cyclooxygenase-2. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26392530 |
Wang H et al. | Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. | 2015 | Cell Rep | pmid:26365195 |
Ho WS et al. | Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol. | 2015 | Br. J. Pharmacol. | pmid:26294342 |
DiPatrizio NV et al. | Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. | 2015 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:26290104 |
Mounsey RB et al. | Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. | 2015 | Exp. Neurol. | pmid:26244281 |
Guggenhuber S et al. | Impaired 2-AG Signaling in Hippocampal Glutamatergic Neurons: Aggravation of Anxiety-Like Behavior and Unaltered Seizure Susceptibility. | 2015 | Int. J. Neuropsychopharmacol. | pmid:26232789 |
Imperatore R et al. | Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CBâ‚R signaling and anxiety-like behavior. | 2015 | J. Neurochem. | pmid:26223500 |
Anderson GR et al. | β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. | 2015 | Cell | pmid:26213384 |
Viader A et al. | Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. | 2015 | Cell Rep | pmid:26212325 |
Straiker A et al. | Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model. | 2015 | Pharmacol. Res. | pmid:26211948 |
González-Mariscal I et al. | Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. | 2016 | Mol. Cell. Endocrinol. | pmid:26724516 |
Rajaraman G et al. | G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction. | 2016 | Mol Nutr Food Res | pmid:26337420 |
Aso C et al. | Protein purification and cloning of diacylglycerol lipase from rat brain. | 2016 | J. Biochem. | pmid:26790472 |
Buczynski MW et al. | Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26755579 |
Imperatore R et al. | Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation. | 2016 | Pharmacol. Res. | pmid:27436148 |
Janssen FJ and van der Stelt M | Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. | 2016 | Bioorg. Med. Chem. Lett. | pmid:27394666 |
Mwanza C et al. | Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27318292 |