2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Fernández-Ochoa à et al. | Urinary and plasma metabolite differences detected by HPLC-ESI-QTOF-MS in systemic sclerosis patients. | 2019 | J Pharm Biomed Anal | pmid:30227356 |
Köse S et al. | Human bone marrow mesenchymal stem cells secrete endocannabinoids that stimulate in vitro hematopoietic stem cell migration effectively comparable to beta-adrenergic stimulation. | 2018 | Exp. Hematol. | pmid:29030083 |
Deng H and van der Stelt M | Chemical tools to modulate 2-arachidonoylglycerol biosynthesis. | 2018 | Biotechnol. Appl. Biochem. | pmid:28589628 |
Szafran BN et al. | Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions. | 2018 | Molecules | pmid:30513753 |
Iannotti FA et al. | Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy. | 2018 | Nat Commun | pmid:30262909 |
Biernacki M et al. | Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. | 2018 | Prostaglandins Other Lipid Mediat. | pmid:30201316 |
DeVuono MV et al. | Conditioned gaping produced by high dose Δ-tetrahydracannabinol: Dysregulation of the hypothalamic endocannabinoid system. | 2018 | Neuropharmacology | pmid:30195587 |
Covey DP et al. | Inhibition of endocannabinoid degradation rectifies motivational and dopaminergic deficits in the Q175 mouse model of Huntington's disease. | 2018 | Neuropsychopharmacology | pmid:29925886 |
Ratano P et al. | Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation. | 2018 | Neuropharmacology | pmid:29842858 |
Jehle J et al. | Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. | 2018 | PLoS ONE | pmid:29813086 |
Forner-Piquer I et al. | Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. | 2018 | Environ. Pollut. | pmid:29793103 |
Kamimura R et al. | Inhibition of 2-arachydonoylgycerol degradation attenuates orofacial neuropathic pain in trigeminal nerve-injured mice. | 2018 | J Oral Sci | pmid:29503395 |
Mecha M et al. | 2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs. | 2018 | Glia | pmid:29484707 |
Turunen PM et al. | Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels. | 2018 | Neuroscience | pmid:29438802 |
Shearer JA et al. | Detrimental effects of 2-arachidonoylglycerol on whole blood platelet aggregation and on cerebral blood flow after a focal ischemic insult in rats. | 2018 | Am. J. Physiol. Heart Circ. Physiol. | pmid:29351454 |
Heinitz S et al. | Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage. | 2018 | J. Clin. Endocrinol. Metab. | pmid:29300902 |
Morena M et al. | Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats. | 2018 | Neuropsychopharmacology | pmid:29265107 |
Eroli F et al. | Differential neuromodulatory role of endocannabinoids in the rodent trigeminal sensory ganglion and cerebral cortex relevant to pain processing. | 2018 | Neuropharmacology | pmid:29225040 |
Sepers MD et al. | Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model. | 2018 | J. Neurosci. | pmid:29192125 |
Signorello MG and Leoncini G | Activation of CaMKKβ/AMPKα pathway by 2-AG in human platelets. | 2018 | J. Cell. Biochem. | pmid:28661046 |