2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Pastor A et al. | A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women. | 2016 | PLoS ONE | pmid:26849214 |
Tegeder I | Endocannabinoids as Guardians of Metastasis. | 2016 | Int J Mol Sci | pmid:26875980 |
Gamelin FX et al. | Effects of chronic exercise on the endocannabinoid system in Wistar rats with high-fat diet-induced obesity. | 2016 | J. Physiol. Biochem. | pmid:26880264 |
Sanchez AM et al. | Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis. | 2016 | Reprod Sci | pmid:26887427 |
Brindisi M et al. | Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. | 2016 | J. Med. Chem. | pmid:26888301 |
Wang X et al. | Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. | 2016 | Biomed Res Int | pmid:26904688 |
Zhang L et al. | Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons. | 2016 | Neuroscience | pmid:26924019 |
Hartley ND et al. | 2-arachidonoylglycerol signaling impairs short-term fear extinction. | 2016 | Transl Psychiatry | pmid:26926885 |
Yan W et al. | NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication. | 2016 | Sci Rep | pmid:26928013 |
Leishman E et al. | Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain. | 2016 | Biochim. Biophys. Acta | pmid:26956082 |
Iannotti FA et al. | Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders. | 2016 | Prog. Lipid Res. | pmid:26965148 |
Limebeer CL et al. | Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model. | 2016 | Behav. Neurosci. | pmid:26974857 |
Feliszek M et al. | Lack of hippocampal CB1 receptor desensitization by Δ(9)-tetrahydrocannabinol in aged mice and by low doses of JZL 184. | 2016 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:26984820 |
Miller MR et al. | Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. | 2016 | Science | pmid:26989199 |
Keyshams N et al. | Cannabinoid-glutamate interactions in the regulation of food intake in neonatal layer- type chicks: role of glutamate NMDA and AMPA receptors. | 2016 | Vet. Res. Commun. | pmid:27000110 |
Delgado-Peraza F et al. | Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor. | 2016 | Mol. Pharmacol. | pmid:27009233 |
Martella A et al. | Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop. | 2016 | Endocrinology | pmid:27014939 |
Brose SA et al. | Brain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia-Injury Which Is Prevented by Microwave Irradiation. | 2016 | Lipids | pmid:27021494 |
Dong L et al. | Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2. | 2016 | J. Lipid Res. | pmid:27059979 |
Sido JM et al. | Production of endocannabinoids by activated TÂ cells and BÂ cells modulates inflammation associated with delayed-type hypersensitivity. | 2016 | Eur. J. Immunol. | pmid:27064137 |
Leishman E et al. | Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. | 2016 | Pharmacol. Res. | pmid:27109320 |
Zou Z et al. | Endocannabinoid 2-Arachidonoylglycerol Suppresses LPS-Induced Inhibition of A-Type Potassium Channel Currents in Caudate Nucleus Neurons Through CB1 Receptor. | 2016 | J. Mol. Neurosci. | pmid:27129498 |
Sharkey KA and Wiley JW | The Role of the Endocannabinoid System in the Brain-Gut Axis. | 2016 | Gastroenterology | pmid:27133395 |
Liisberg U et al. | Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice. | 2016 | J. Nutr. Biochem. | pmid:27155918 |
Chen Y et al. | Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum. | 2016 May-Jun | eNeuro | pmid:27182552 |
Reddy IA et al. | Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. | 2016 | Transl Psychiatry | pmid:27187231 |
Araki M et al. | Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase. | 2016 | J. Biochem. | pmid:27198176 |
Battista N and Sergi M | Determination of 2-Arachidonoylglycerol by μSPE-LC-MS/MS. | 2016 | Methods Mol. Biol. | pmid:27245888 |
Bisogno T | Assay of DAGLα/β Activity. | 2016 | Methods Mol. Biol. | pmid:27245901 |
Jung KM and Piomelli D | Assay of Monoacylglycerol Lipase Activity. | 2016 | Methods Mol. Biol. | pmid:27245902 |
Kudalkar SN et al. | Assay of Endocannabinoid Oxidation by Cyclooxygenase-2. | 2016 | Methods Mol. Biol. | pmid:27245906 |
van Zadelhoff G and van der Stelt M | Oxygenation of Anandamide by Lipoxygenases. | 2016 | Methods Mol. Biol. | pmid:27245907 |
Mwanza C et al. | Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27318292 |
Malek N et al. | The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain. | 2016 | Pharmacol. Res. | pmid:27326920 |
Wiley JL et al. | Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice. | 2016 | Behav Pharmacol | pmid:27385208 |
Janssen FJ and van der Stelt M | Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. | 2016 | Bioorg. Med. Chem. Lett. | pmid:27394666 |
Imperatore R et al. | Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation. | 2016 | Pharmacol. Res. | pmid:27436148 |
Tung LW et al. | Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. | 2016 | Nat Commun | pmid:27448020 |
Veeraraghavan P et al. | A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro. | 2016 | Neuroscience | pmid:27450568 |
Aaltonen N et al. | In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048). | 2016 | J. Pharmacol. Exp. Ther. | pmid:27451409 |
Bosch-Bouju C et al. | Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress. | 2016 | Cell Rep | pmid:27452462 |
Sugaya Y et al. | Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures. | 2016 | Cell Rep | pmid:27452464 |
Doenni VM et al. | Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. | 2016 | Brain Behav. Immun. | pmid:27453335 |
Di S et al. | Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. | 2016 | J. Neurosci. | pmid:27511017 |
Morena M et al. | Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. | 2016 | Neuropharmacology | pmid:27553121 |
Saravia R et al. | CB Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal. | 2017 | Biol. Psychiatry | pmid:27737762 |
Liu X et al. | Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase. | 2016 | Sci Rep | pmid:27775008 |
Fisette A et al. | α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. | 2016 | Cell Rep | pmid:27783937 |
Matthews AT et al. | Oxyradical stress increases the biosynthesis of 2-arachidonoylglycerol: involvement of NADPH oxidase. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:27784678 |
Wang X et al. | Endogenous cannabinoid system alterations and their role in epileptogenesis after brain injury in rat. | 2016 | Epilepsy Res. | pmid:27810514 |
Zelber-Sagi S et al. | Serum levels of endocannabinoids are independently associated with nonalcoholic fatty liver disease. | 2017 | Obesity (Silver Spring) | pmid:27863097 |
Barbonetti A et al. | 2-arachidonoylglycerol levels are increased in leukocytospermia and correlate with seminal macrophages. | 2017 | Andrology | pmid:27863106 |
Hassanzadeh P et al. | Application of carbon nanotubes as the carriers of the cannabinoid, 2-arachidonoylglycerol: Towards a novel treatment strategy in colitis. | 2017 | Life Sci. | pmid:27888115 |
Wilkerson JL et al. | The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. | 2017 | Neuropharmacology | pmid:27890602 |
Knani I et al. | Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome. | 2016 | Mol Metab | pmid:27900261 |
Schlabritz-Loutsevitch N et al. | Fetal Syndrome of Endocannabinoid Deficiency (FSECD) In Maternal Obesity. | 2016 | Med. Hypotheses | pmid:27959272 |
Kantae V et al. | Quantitative profiling of endocannabinoids and related -acylethanolamines in human CSF using nano LC-MS/MS. | 2017 | J. Lipid Res. | pmid:27999147 |
Stark DT and Caprioli J | Subcellular Localization of a 2-Arachidonoyl Glycerol Signaling Cassette in Retinal Ganglion Cell Axonal Growth In Vitro. | 2016 | Invest. Ophthalmol. Vis. Sci. | pmid:28002563 |
Thompson Z et al. | Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes. | 2017 | Physiol. Behav. | pmid:28017680 |
Artegoitia VM et al. | Endocannabinoids concentrations in plasma associated with feed efficiency and carcass composition of beef steers. | 2016 | J. Anim. Sci. | pmid:28046144 |
Argueta DA and DiPatrizio NV | Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity. | 2017 | Physiol. Behav. | pmid:28065722 |
Tanaka M et al. | WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism. | 2017 | J Neuroinflammation | pmid:28086912 |
Quartu M et al. | Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion. | 2017 | Lipids Health Dis | pmid:28103941 |
Li B et al. | Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain. | 2017 | J Environ Sci (China) | pmid:28115138 |
Pagano E et al. | Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis. | 2017 | Pharmacol. Res. | pmid:28193521 |
Dotsey E et al. | Transient Cannabinoid Receptor 2 Blockade during Immunization Heightens Intensity and Breadth of Antigen-specific Antibody Responses in Young and Aged mice. | 2017 | Sci Rep | pmid:28209996 |
Haruna T et al. | The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice. | 2017 | Pharmacology | pmid:28214870 |
Smaga I et al. | Changes in the Brain Endocannabinoid System in Rat Models of Depression. | 2017 | Neurotox Res | pmid:28247204 |
Bakas T et al. | The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABA receptors. | 2017 | Pharmacol. Res. | pmid:28249817 |
Gantz SC and Bean BP | Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling. | 2017 | Neuron | pmid:28262417 |
Cui N et al. | Restored Plasma Anandamide and Endometrial Expression of Fatty Acid Amide Hydrolase in Women With Polycystic Ovary Syndrome by the Combination Use of Diane-35 and Metformin. | 2017 | Clin Ther | pmid:28291580 |
Brellenthin AG et al. | Endocannabinoid and Mood Responses to Exercise in Adults with Varying Activity Levels. | 2017 | Med Sci Sports Exerc | pmid:28319590 |
Chanda D et al. | 2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes. | 2017 | J. Biol. Chem. | pmid:28320859 |
Marchioni C et al. | A column switching ultrahigh-performance liquid chromatography-tandem mass spectrometry method to determine anandamide and 2-arachidonoylglycerol in plasma samples. | 2017 | Anal Bioanal Chem | pmid:28337517 |
Kranaster L et al. | Electroconvulsive therapy enhances endocannabinoids in the cerebrospinal fluid of patients with major depression: a preliminary prospective study. | 2017 | Eur Arch Psychiatry Clin Neurosci | pmid:28342110 |
Bluett RJ et al. | Endocannabinoid signalling modulates susceptibility to traumatic stress exposure. | 2017 | Nat Commun | pmid:28348378 |
Karpińska O et al. | Activation of CB receptors by 2-arachidonoylglycerol attenuates vasoconstriction induced by U46619 and angiotensin II in human and rat pulmonary arteries. | 2017 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:28356298 |
Pasquarelli N et al. | Evaluation of monoacylglycerol lipase as a therapeutic target in a transgenic mouse model of ALS. | 2017 | Neuropharmacology | pmid:28373073 |
Vujic N et al. | Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice. | 2017 | Oncotarget | pmid:28380440 |
Soni N et al. | Anandamide and 2-AG are endogenously present within the laterodorsal tegmental nucleus: Functional implications for a role of eCBs in arousal. | 2017 | Brain Res. | pmid:28404451 |
Karwad MA et al. | The role of CB in intestinal permeability and inflammation. | 2017 | FASEB J. | pmid:28404744 |
Bedse G et al. | Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety. | 2017 | Biol. Psychiatry | pmid:28438413 |
Almeida-Santos AF et al. | 2-Arachidonoylglycerol endocannabinoid signaling coupled to metabotropic glutamate receptor type-5 modulates anxiety-like behavior in the rat ventromedial prefrontal cortex. | 2017 | J. Psychopharmacol. (Oxford) | pmid:28440729 |
Fanelli F et al. | Plasma 2-arachidonoylglycerol is a biomarker of age and menopause related insulin resistance and dyslipidemia in lean but not in obese men and women. | 2017 | Mol Metab | pmid:28462075 |
Becker TM et al. | Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese mice. | 2017 | Mol Metab | pmid:28580289 |
Chicca A et al. | Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28584105 |
Francou MM et al. | Human sperm motility, capacitation and acrosome reaction are impaired by 2-arachidonoylglycerol endocannabinoid. | 2017 | Histol. Histopathol. | pmid:28585678 |
Deng H and van der Stelt M | Chemical tools to modulate 2-arachidonoylglycerol biosynthesis. | 2018 | Biotechnol. Appl. Biochem. | pmid:28589628 |
Avraham Y et al. | 2-Arachidonoylglycerol as a possible treatment for anorexia nervosa in animal model in mice. | 2017 | Brain Res. | pmid:28606779 |
Signorello MG and Leoncini G | Activation of CaMKKβ/AMPKα pathway by 2-AG in human platelets. | 2018 | J. Cell. Biochem. | pmid:28661046 |
Abed SM et al. | Synthesis of 1,3-dioleoyl-2-arachidonoylglycerol-rich structured lipids by lipase-catalyzed acidolysis of microbial oil from Mortierella alpina. | 2017 | Bioresour. Technol. | pmid:28688328 |
Summers T et al. | Endocannabinoids Have Opposing Effects On Behavioral Responses To Nociceptive And Non-nociceptive Stimuli. | 2017 | Sci Rep | pmid:28724917 |
Xu C et al. | Endocannabinoids exert CB receptor-mediated neuroprotective effects in models of neuronal damage induced by HIV-1 Tat protein. | 2017 | Mol. Cell. Neurosci. | pmid:28733129 |
Feliú A et al. | 2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination. | 2017 | J. Neurosci. | pmid:28751457 |
Buntyn RW et al. | Inhibition of Endocannabinoid-Metabolizing Enzymes in Peripheral Tissues Following Developmental Chlorpyrifos Exposure in Rats. | Int. J. Toxicol. | pmid:28820005 | |
Pascual AC et al. | 2-Arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminals. | 2017 | Neuroscience | pmid:28844762 |
Martin GG et al. | Endocannabinoid Interaction with Human FABP1: Impact of the T94A Variant. | 2017 | Biochemistry | pmid:28853554 |
Raff H et al. | Increase in the circulating endocannabinoid 2-arachidonoylglycerol is associated with gabapentin use in septic ICU patients. | 2017 | Endocrine | pmid:28875451 |
Poursharifi P et al. | Monoacylglycerol signalling and ABHD6 in health and disease. | 2017 | Diabetes Obes Metab | pmid:28880480 |
Forner-Piquer I et al. | Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish. | 2017 | Endocrinology | pmid:28938452 |