2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Spivak CE et al. | Blockade of β-cell K(ATP) channels by the endocannabinoid, 2-arachidonoylglycerol. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22609205 |
Chicca A et al. | The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors. | 2012 | Br. J. Pharmacol. | pmid:22646533 |
Mimura T et al. | Involvement of the endogenous cannabinoid 2 ligand 2-arachidonyl glycerol in allergic inflammation. | 2012 | Int. Arch. Allergy Immunol. | pmid:22652530 |
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Forsell PK et al. | Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. | 2012 | Lipids | pmid:22684912 |
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Raman P et al. | 15-Deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor γ ligand, modulates nuclear factor of activated T cells. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22700433 |
Deshmukh RR and Sharma PL | Stimulation of accumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats. | 2012 | Pharmacol. Res. | pmid:22728691 |
Higuchi S et al. | Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. | 2012 | PLoS ONE | pmid:22737214 |
Li C et al. | Expression and function of monoacylglycerol lipase in mouse β-cells and human islets of Langerhans. | 2012 | Cell. Physiol. Biochem. | pmid:22739267 |
Tanimura A et al. | Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22783023 |
Gregg LC et al. | Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. | 2012 | J. Neurosci. | pmid:22787031 |
Luchicchi A and Pistis M | Anandamide and 2-arachidonoylglycerol: pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids. | 2012 | Mol. Neurobiol. | pmid:22801993 |
Krishnan G and Chatterjee N | Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation. | 2012 | Glia | pmid:22807196 |
Carloni S et al. | Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. | 2012 | Pediatr. Res. | pmid:22821058 |
Lara-Celador I et al. | Endocannabinoids reduce cerebral damage after hypoxic-ischemic injury in perinatal rats. | 2012 | Brain Res. | pmid:22841538 |
Echigo R et al. | Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells. | 2012 | Oncol. Rep. | pmid:22842590 |
Sergi M et al. | Determination of the two major endocannabinoids in human plasma by μ-SPE followed by HPLC-MS/MS. | 2013 | Anal Bioanal Chem | pmid:22847477 |
Chicca A et al. | Evidence for bidirectional endocannabinoid transport across cell membranes. | 2012 | J. Biol. Chem. | pmid:22879589 |
Kortleven C et al. | Neurotensin inhibits glutamate-mediated synaptic inputs onto ventral tegmental area dopamine neurons through the release of the endocannabinoid 2-AG. | 2012 | Neuropharmacology | pmid:22884466 |
Tanveer R et al. | The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats. | 2012 | J. Biol. Chem. | pmid:22891244 |
Alhouayek M and Muccioli GG | The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. | 2012 | Trends Mol Med | pmid:22917662 |
Woodhams SG et al. | Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. | 2012 | Br. J. Pharmacol. | pmid:22924700 |
Wang DJ et al. | Cytosolic phospholipase A2 alpha/arachidonic acid signaling mediates depolarization-induced suppression of excitation in the cerebellum. | 2012 | PLoS ONE | pmid:22927908 |
Chon SH et al. | Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity. | 2012 | PLoS ONE | pmid:22937137 |
Musee J and Marnett LJ | Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid. | 2012 | J. Biol. Chem. | pmid:22942274 |
Navia-Paldanius D et al. | Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). | 2012 | J. Lipid Res. | pmid:22969151 |
Chanda D et al. | Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene. | 2012 | J. Biol. Chem. | pmid:22989885 |
Hauer D et al. | Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression. | 2012 | Rev Neurosci | pmid:23006898 |
Jung KM et al. | Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. | 2012 | Nat Commun | pmid:23011134 |
Strewe C et al. | Effects of parabolic flight and spaceflight on the endocannabinoid system in humans. | 2012 | Rev Neurosci | pmid:23023882 |
Kerr DM et al. | The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. | 2013 | Br. J. Pharmacol. | pmid:23043675 |
Han B et al. | Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor. | 2013 | Anal. Biochem. | pmid:23044255 |
Bisogno T et al. | A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. | 2013 | Br. J. Pharmacol. | pmid:23072382 |
Jones BR et al. | Surrogate matrix and surrogate analyte approaches for definitive quantitation of endogenous biomolecules. | 2012 | Bioanalysis | pmid:23088461 |
Hsu KL et al. | DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. | 2012 | Nat. Chem. Biol. | pmid:23103940 |
Skaper SD and Di Marzo V | Endocannabinoids in nervous system health and disease: the big picture in a nutshell. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108539 |
Di Marzo V and De Petrocellis L | Why do cannabinoid receptors have more than one endogenous ligand? | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108541 |
Puighermanal E et al. | Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108544 |
Reisenberg M et al. | The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108545 |
Melis M and Pistis M | Hub and switches: endocannabinoid signalling in midbrain dopamine neurons. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108546 |
Starowicz K and Przewlocka B | Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108547 |
Rani Sagar D et al. | Dynamic changes to the endocannabinoid system in models of chronic pain. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108548 |
Guindon J et al. | Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. | 2013 | Pharmacol. Res. | pmid:23127915 |
Yang Y et al. | Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. | 2013 | Cell. Signal. | pmid:23142606 |
Tchantchou F and Zhang Y | Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. | 2013 | J. Neurotrauma | pmid:23151067 |
Citraro R et al. | Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy. | 2013 | Neuropharmacology | pmid:23206503 |
Rivera P et al. | Cocaine self-administration differentially modulates the expression of endogenous cannabinoid system-related proteins in the hippocampus of Lewis vs. Fischer 344 rats. | 2013 | Int. J. Neuropsychopharmacol. | pmid:23217608 |
Jäntti MH et al. | Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling. | 2013 | Mol. Pharmacol. | pmid:23233488 |
Chouinard F et al. | 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV. | 2013 | J. Leukoc. Biol. | pmid:23242611 |