2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sheinin A et al. | Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. | 2008 | J. Neurophysiol. | pmid:18497350 |
| Zhang J and Chen C | Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. | 2008 | J. Biol. Chem. | pmid:18534982 |
| Di Filippo M et al. | Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. | 2008 | J. Neurol. Neurosurg. Psychiatr. | pmid:18535023 |
| Nabemoto M et al. | Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha. | 2008 | Eur. J. Pharmacol. | pmid:18539271 |
| Palmer JA et al. | Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. | 2008 | Neuroscience | pmid:18541380 |
| Qin N et al. | TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. | 2008 | J. Neurosci. | pmid:18550765 |
| Motaghedi R and McGraw TE | The CB1 endocannabinoid system modulates adipocyte insulin sensitivity. | 2008 | Obesity (Silver Spring) | pmid:18551116 |
| Endsley MP et al. | Expression and function of fatty acid amide hydrolase in prostate cancer. | 2008 | Int. J. Cancer | pmid:18566995 |
| Rockwell CE et al. | A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells. | 2008 | Biochem. Pharmacol. | pmid:18571623 |
| Njie YF et al. | Aqueous humor outflow effects of 2-arachidonylglycerol. | 2008 | Exp. Eye Res. | pmid:18597752 |
| Baldassarri S et al. | The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors. | 2008 | J. Thromb. Haemost. | pmid:18647220 |
| Hoover HS et al. | Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18657971 |
| Llorente R et al. | Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system. | 2008 | Dev Neurobiol | pmid:18666205 |
| Ellgren M et al. | Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. | 2008 | Eur Neuropsychopharmacol | pmid:18674887 |
| Fowler CJ and Ghafouri N | Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? | 2008 | Pharmacol. Res. | pmid:18675915 |
| Burston JJ et al. | N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18682568 |
| Nomura DK et al. | Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18752948 |
| Placzek EA et al. | Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. | 2008 | Neuropharmacology | pmid:18760289 |
| Avraham Y et al. | 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the evolution of experimental cholestatic liver disease. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18771906 |
| Placzek EA et al. | Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. | 2008 | J. Neurochem. | pmid:18778304 |