2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Battista N et al. | The role of endocannabinoids in gonadal function and fertility along the evolutionary axis. | 2012 | Mol. Cell. Endocrinol. | pmid:22305972 |
Wang PF et al. | Cannabinoid-2 receptor activation protects against infarct and ischemia-reperfusion heart injury. | 2012 | J. Cardiovasc. Pharmacol. | pmid:22113346 |
Alhouayek M and Muccioli GG | The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. | 2012 | Trends Mol Med | pmid:22917662 |
Nithipatikom K et al. | Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells. | 2012 | Endocrinology | pmid:22087025 |
Deshmukh RR and Sharma PL | Stimulation of accumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats. | 2012 | Pharmacol. Res. | pmid:22728691 |
Clemente JC et al. | Screening and characterization of human monoglyceride lipase active site inhibitors using orthogonal binding and functional assays. | 2012 | J Biomol Screen | pmid:22496098 |
Wu X et al. | Alteration of endocannabinoid system in human gliomas. | 2012 | J. Neurochem. | pmid:22176552 |
Wang M et al. | Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation. | 2012 | J. Psychopharmacol. (Oxford) | pmid:21890595 |
Savinainen JR et al. | The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors. | 2012 | Acta Physiol (Oxf) | pmid:21418147 |
Mimura T et al. | Involvement of the endogenous cannabinoid 2 ligand 2-arachidonyl glycerol in allergic inflammation. | 2012 | Int. Arch. Allergy Immunol. | pmid:22652530 |
Luchicchi A and Pistis M | Anandamide and 2-arachidonoylglycerol: pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids. | 2012 | Mol. Neurobiol. | pmid:22801993 |
Jung KM et al. | 2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. | 2012 | Cell Metab. | pmid:22405068 |
Krishnan G and Chatterjee N | Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation. | 2012 | Glia | pmid:22807196 |
Lara-Celador I et al. | Endocannabinoids reduce cerebral damage after hypoxic-ischemic injury in perinatal rats. | 2012 | Brain Res. | pmid:22841538 |
Hsu KL et al. | DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. | 2012 | Nat. Chem. Biol. | pmid:23103940 |
Reisenberg M et al. | The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108545 |
Jones BR et al. | Surrogate matrix and surrogate analyte approaches for definitive quantitation of endogenous biomolecules. | 2012 | Bioanalysis | pmid:23088461 |
Hauer D et al. | Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression. | 2012 | Rev Neurosci | pmid:23006898 |
Psychoyos D et al. | Cannabinoid receptor 1 signaling in embryo neurodevelopment. | 2012 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:22311661 |
Alger BE | Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know. | 2012 | J. Physiol. (Lond.) | pmid:22289914 |