2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kim J and Alger BE | Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. | 2010 | Nat. Neurosci. | pmid:20348918 |
Makara JK et al. | Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. | 2005 | Nat. Neurosci. | pmid:16116451 |
Hohmann AG et al. | An endocannabinoid mechanism for stress-induced analgesia. | 2005 | Nature | pmid:15973410 |
Di Marzo V et al. | Trick or treat from food endocannabinoids? | 1998 | Nature | pmid:9872309 |
Panikashvili D et al. | An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. | 2001 | Nature | pmid:11586361 |
Di Marzo V et al. | Leptin-regulated endocannabinoids are involved in maintaining food intake. | 2001 | Nature | pmid:11298451 |
Wilson RI and Nicoll RA | Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. | 2001 | Nature | pmid:11279497 |
Stella N et al. | A second endogenous cannabinoid that modulates long-term potentiation. | 1997 | Nature | pmid:9285589 |
Feliszek M et al. | Lack of hippocampal CB1 receptor desensitization by Δ(9)-tetrahydrocannabinol in aged mice and by low doses of JZL 184. | 2016 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:26984820 |
Schulte K et al. | Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor. | 2012 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:22215206 |
Ameri A and Simmet T | Effects of 2-arachidonylglycerol, an endogenous cannabinoid, on neuronal activity in rat hippocampal slices. | 2000 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:10731038 |
Ilayan E et al. | Do cannabinoids exhibit a tyramine-like effect? | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23900610 |
Jergas B et al. | O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus. | 2014 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:24853577 |
Fernández-Suárez D et al. | Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. | 2014 | Neurobiol. Aging | pmid:24973119 |
Arevalo-Martin A et al. | The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury. | 2010 | Neurobiol. Dis. | pmid:20156559 |
Piomelli D et al. | Endogenous cannabinoid signaling. | 1998 | Neurobiol. Dis. | pmid:9974178 |
Panikashvili D et al. | The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. | 2006 | Neurobiol. Dis. | pmid:16364651 |
Garcia-Ovejero D et al. | The endocannabinoid system is modulated in response to spinal cord injury in rats. | 2009 | Neurobiol. Dis. | pmid:18930143 |
Melis M et al. | Protective activation of the endocannabinoid system during ischemia in dopamine neurons. | 2006 | Neurobiol. Dis. | pmid:16762556 |
Cabranes A et al. | Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis. | 2005 | Neurobiol. Dis. | pmid:16242629 |