2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Belluomo I et al. | Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes. | 2015 | J. Neurochem. | pmid:25626460 |
Brosnihan KB et al. | Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. | 2015 | Reprod. Biol. Endocrinol. | pmid:25596750 |
Griebel G et al. | Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. | 2015 | Sci Rep | pmid:25560837 |
Zhang J et al. | Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. | 2015 | J. Cereb. Blood Flow Metab. | pmid:25492114 |
Shonesy BC et al. | The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. | 2015 | Neuropharmacology | pmid:25484252 |
Martins CJ et al. | Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. | 2015 | PLoS ONE | pmid:26561012 |
Hanlon EC et al. | Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol. | 2015 | J. Clin. Endocrinol. Metab. | pmid:25368979 |
Petrenko AB et al. | Genetic inactivation and prolonged pharmacologic inhibition of monoacylglycerol lipase have opposite effects on anesthetic sensitivity to propofol. | 2015 | Eur. J. Pharmacol. | pmid:26318148 |
Zou Z et al. | Effect of Homocysteine on Voltage-Gated Sodium Channel Currents in Primary Cultured Rat Caudate Nucleus Neurons and Its Modulation by 2-Arachidonylglycerol. | 2015 | J. Mol. Neurosci. | pmid:26179279 |
GarcÃa del Caño G et al. | Nuclear diacylglycerol lipase-α in rat brain cortical neurons: evidence of 2-arachidonoylglycerol production in concert with phospholipase C-β activity. | 2015 | J. Neurochem. | pmid:25308538 |
Ma L et al. | Involvement of cannabinoid receptors in infrasonic noise-induced neuronal impairment. | 2015 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:26058582 |
Katz PS et al. | Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury. | 2015 | J. Neurotrauma | pmid:25166905 |
Alizadeh A et al. | Role of cannabinoidergic system on food intake in neonatal layer-type chicken. | 2015 | Vet. Res. Commun. | pmid:25902906 |
Mennella I et al. | Food Liking Enhances the Plasma Response of 2-Arachidonoylglycerol and of Pancreatic Polypeptide upon Modified Sham Feeding in Humans. | 2015 | J. Nutr. | pmid:26180248 |
Li B et al. | Endogenous 2-Arachidonoylglycerol Alleviates Cyclooxygenases-2 Elevation-Mediated Neuronal Injury From SO2 Inhalation via PPARγ Pathway. | 2015 | Toxicol. Sci. | pmid:26209559 |
Costa MA et al. | 2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental development. | 2015 | Mol. Cell. Endocrinol. | pmid:25199616 |
Dong M et al. | Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against homocysteine-induced impairments in rat caudate nucleus through CB1 receptor. | 2015 | J. Mol. Neurosci. | pmid:25007951 |
Turcotte C et al. | Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites. | 2015 | J. Leukoc. Biol. | pmid:25877930 |
Ivanov I et al. | A simple method for simultaneous determination of N-arachidonoylethanolamine, N-oleoylethanolamine, N-palmitoylethanolamine and 2-arachidonoylglycerol in human cells. | 2015 | Anal Bioanal Chem | pmid:25519724 |
Scotchie JG et al. | Endocannabinoid regulation in human endometrium across the menstrual cycle. | 2015 | Reprod Sci | pmid:24819878 |
Pasquarelli N et al. | Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue. | 2015 | Neuropharmacology | pmid:25497453 |
Qi M et al. | A robust capillary liquid chromatography/tandem mass spectrometry method for quantitation of neuromodulatory endocannabinoids. | 2015 | Rapid Commun. Mass Spectrom. | pmid:26411510 |
Cascio MG and Marini P | Biosynthesis and Fate of Endocannabinoids. | 2015 | Handb Exp Pharmacol | pmid:26408157 |
Piyanova A et al. | Age-related changes in the endocannabinoid system in the mouse hippocampus. | 2015 | Mech. Ageing Dev. | pmid:26278494 |
Mecha M et al. | Endocannabinoids drive the acquisition of an alternative phenotype in microglia. | 2015 | Brain Behav. Immun. | pmid:26086345 |
Juan CC et al. | Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome. | 2015 | Fertil. Steril. | pmid:25935491 |
Vázquez C et al. | Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies. | 2015 | Neurobiol. Dis. | pmid:25917763 |
Jokisch V et al. | Endocannabinoid Levels in Newborns in Relation to the Mode of Delivery. | 2015 | Am J Perinatol | pmid:25915139 |
Manduca A et al. | Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. | 2015 | Eur Neuropsychopharmacol | pmid:25914159 |
Liu J et al. | Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum. | 2015 | Neurotoxicology | pmid:26215119 |
Ford GK et al. | Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. | 2015 | Eur J Pain | pmid:25504741 |
Sticht MA et al. | Intra-visceral insular cortex 2-arachidonoylglycerol, but not N-arachidonoylethanolamide, suppresses acute nausea-induced conditioned gaping in rats. | 2015 | Neuroscience | pmid:25499318 |
Orellana-Serradell O et al. | Proapoptotic effect of endocannabinoids in prostate cancer cells. | 2015 | Oncol. Rep. | pmid:25606819 |
Pacioni G et al. | Truffles contain endocannabinoid metabolic enzymes and anandamide. | 2015 | Phytochemistry | pmid:25433633 |
Alhouayek M et al. | N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis. | 2015 | FASEB J. | pmid:25384424 |
Park SW et al. | Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species. | 2015 | Head Neck | pmid:24797795 |
Checa A et al. | Lipid mediator profile in vernix caseosa reflects skin barrier development. | 2015 | Sci Rep | pmid:26521946 |
Mounsey RB et al. | Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. | 2015 | Exp. Neurol. | pmid:26244281 |
Guggenhuber S et al. | Impaired 2-AG Signaling in Hippocampal Glutamatergic Neurons: Aggravation of Anxiety-Like Behavior and Unaltered Seizure Susceptibility. | 2015 | Int. J. Neuropsychopharmacol. | pmid:26232789 |
Imperatore R et al. | Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CBâ‚R signaling and anxiety-like behavior. | 2015 | J. Neurochem. | pmid:26223500 |
Anderson GR et al. | β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. | 2015 | Cell | pmid:26213384 |
Viader A et al. | Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. | 2015 | Cell Rep | pmid:26212325 |
Straiker A et al. | Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model. | 2015 | Pharmacol. Res. | pmid:26211948 |
Kita Y et al. | Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2. | 2015 | PLoS ONE | pmid:26196692 |
Lee SH et al. | Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release. | 2015 | J. Neurosci. | pmid:26157003 |
Parker KE et al. | Effects of co-administration of 2-arachidonylglycerol (2-AG) and a selective µ-opioid receptor agonist into the nucleus accumbens on high-fat feeding behaviors in the rat. | 2015 | Brain Res. | pmid:26100333 |
La Porta C et al. | Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain. | 2015 | Pain | pmid:26067584 |
Hutch CR et al. | An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction. | 2015 | Neuroscience | pmid:26037800 |
Dotsey EY et al. | Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. | 2015 | Chem. Biol. | pmid:26000748 |
Chicca A et al. | 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. | 2015 | J Neuroinflammation | pmid:25962384 |