| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acute Pain | D059787 | 3 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Fetal Nutrition Disorders | D048070 | 1 associated lipids |
| Ganglion Cysts | D045888 | 1 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Cholangiocarcinoma | D018281 | 7 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Head Injuries, Closed | D016489 | 5 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Myocardial Reperfusion Injury | D015428 | 20 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Starvation | D013217 | 47 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Obesity | D009765 | 29 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Laine K et al. | Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12356827 |
| Darmani NA | The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids. | 2002 | J. Pharmacol. Exp. Ther. | pmid:11752094 |
| González S et al. | Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine. | 2002 | Brain Res. | pmid:12393235 |
| Razdan RK and Mahadevan A | Recent advances in the synthesis of endocannabinoid related ligands. | 2002 | Chem. Phys. Lipids | pmid:12505687 |
| Kunos G et al. | The quest for a vascular endothelial cannabinoid receptor. | 2002 | Chem. Phys. Lipids | pmid:12505689 |
| Schmid HH et al. | Cell signaling by endocannabinoids and their congeners: questions of selectivity and other challenges. | 2002 | Chem. Phys. Lipids | pmid:12505695 |
| Sugiura T et al. | Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. | 2002 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12052034 |
| Fowler CJ and Jacobsson SO | Cellular transport of anandamide, 2-arachidonoylglycerol and palmitoylethanolamide--targets for drug development? | 2002 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12052035 |
| Högestätt ED and Zygmunt PM | Cardiovascular pharmacology of anandamide. | 2002 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12052048 |
| van der Stelt M et al. | Acute neuronal injury, excitotoxicity, and the endocannabinoid system. | 2002 Oct-Dec | Mol. Neurobiol. | pmid:12428763 |
| Patel S et al. | Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12808005 |
| Watanabe S et al. | n-3 Polyunsaturated fatty acid (PUFA) deficiency elevates and n-3 PUFA enrichment reduces brain 2-arachidonoylglycerol level in mice. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878451 |
| Hanus L et al. | Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain. | 2003 | Brain Res. | pmid:12914975 |
| Maccarrone M et al. | Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. | 2003 | J. Biol. Chem. | pmid:12799380 |
| Franklin A et al. | Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. | 2003 | J. Neurosci. | pmid:12944505 |
| Liu J et al. | Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. | 2003 | J. Biol. Chem. | pmid:12949078 |
| Derkinderen P et al. | Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. | 2003 | J. Neurosci. | pmid:12657697 |
| Gaetani S et al. | Anandamide hydrolysis: a new target for anti-anxiety drugs? | 2003 | Trends Mol Med | pmid:14604824 |
| Lépicier P et al. | Endocannabinoids protect the rat isolated heart against ischaemia. | 2003 | Br. J. Pharmacol. | pmid:12813004 |
| Marsicano G et al. | CB1 cannabinoid receptors and on-demand defense against excitotoxicity. | 2003 | Science | pmid:14526074 |