2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Weight Gain D015430 101 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Glioma D005910 112 associated lipids
Obesity D009765 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Nervous System Diseases D009422 37 associated lipids
Brain Edema D001929 20 associated lipids
Starvation D013217 47 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
Prusakiewicz JJ et al. Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid. 2009 Biochemistry pmid:19603831
Astarita G et al. Targeted lipidomics as a tool to investigate endocannabinoid function. 2009 Int. Rev. Neurobiol. pmid:19607960
Morgan NH et al. Functional CB2 type cannabinoid receptors at CNS synapses. 2009 Neuropharmacology pmid:19616018
Amorós I et al. Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner. 2010 J. Mol. Cell. Cardiol. pmid:19616555
Tsuyama S et al. Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. 2009 Nutr Neurosci pmid:19622239
Long JZ et al. Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. 2009 Chem. Biol. pmid:19635411
Alvarez-Jaimes L et al. Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats. 2009 J. Neurochem. pmid:19650871
Li Q and Burrell BD Two forms of long-term depression in a polysynaptic pathway in the leech CNS: one NMDA receptor-dependent and the other cannabinoid-dependent. 2009 J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. pmid:19657662
Lane JR et al. The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor. 2010 Biochem. Pharmacol. pmid:19665453
Pan B et al. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. 2009 J. Pharmacol. Exp. Ther. pmid:19666749
Patel S et al. Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. 2009 Neuropsychopharmacology pmid:19675536
Duclos RI The total synthesis of 2-O-arachidonoyl-1-O-stearoyl-sn-glycero-3-phosphocholine-1,3,1'-(13)C3 and -2,1'-(13)C2 by a novel chemoenzymatic method. 2010 Chem. Phys. Lipids pmid:19682980
Thors L and Fowler CJ Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids. 2009 Eur. J. Pharmacol. pmid:19715690
Di Marzo V et al. Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. 2009 Eur. J. Endocrinol. pmid:19745037
Schroeder C et al. Circulating endocannabinoid concentrations during orthostatic stress. 2009 Clin. Auton. Res. pmid:19756829
Avraham Y et al. Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice. 2009 Br. J. Pharmacol. pmid:19764982
Straiker A et al. Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. 2009 Mol. Pharmacol. pmid:19767452
Piccinetti CC et al. Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. 2010 Gen. Comp. Endocrinol. pmid:19800340
Gkini E et al. Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase. 2009 Platelets pmid:19811221
Cobellis G et al. A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up. 2010 Biol. Reprod. pmid:19812302
Romigi A et al. Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. 2010 Epilepsia pmid:19817812
Maison P et al. BDNF regulates neuronal sensitivity to endocannabinoids. 2009 Neurosci. Lett. pmid:19818836
Guindon J and Hohmann AG The endocannabinoid system and pain. 2009 CNS Neurol Disord Drug Targets pmid:19839937
Caraceni P et al. Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. 2010 Liver Int. pmid:19840245
Zhang SY et al. Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. 2009 J. Neurosci. pmid:19846710
Won YJ et al. Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons. 2009 J. Neurosci. pmid:19864572
Telleria-Diaz A et al. Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids. 2010 Pain pmid:19879047
Bradshaw H CB1-induced side effects of specific COX-2 inhibitors: a feature, not a bug. 2010 Pain pmid:19913999
Long JZ et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19918051
Marco EM and Viveros MP The critical role of the endocannabinoid system in emotional homeostasis: avoiding excess and deficiencies. 2009 Mini Rev Med Chem pmid:19929814
Weis F et al. Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure. 2010 J. Mol. Cell. Cardiol. pmid:19931541
Zhang MY et al. Simultaneous determination of 2-arachidonoylglycerol, 1-arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry. 2010 J Mass Spectrom pmid:19950120
Labar G et al. Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. 2010 Chembiochem pmid:19957260
Banni S and Di Marzo V Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood. 2010 Mol Nutr Food Res pmid:20013888
Eisenstein SA et al. A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. 2010 Pharmacol. Res. pmid:20044005
Sang N et al. Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway. 2010 Neurochem. Int. pmid:20064571
Lourenço J et al. Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. 2010 Nat. Neurosci. pmid:20081851
Carrasquer A et al. Functional consequences of nonsynonymous single nucleotide polymorphisms in the CB2 cannabinoid receptor. 2010 Pharmacogenet. Genomics pmid:20124950
Guida M et al. The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma. 2010 Endocrinology pmid:20133454
Casida JE et al. S-Arachidonoyl-2-thioglycerol synthesis and use for fluorimetric and colorimetric assays of monoacylglycerol lipase. 2010 Bioorg. Med. Chem. pmid:20138526
Gao Y et al. Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. 2010 J. Neurosci. pmid:20147530
Lerner TN et al. Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. 2010 J. Neurosci. pmid:20147543
Arevalo-Martin A et al. The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury. 2010 Neurobiol. Dis. pmid:20156559
Best AR and Regehr WG Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain. 2010 Neuron pmid:20159441
Yasuo S et al. An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes. 2010 Cell Tissue Res. pmid:20165884
Reggio PH Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. 2010 Curr. Med. Chem. pmid:20166921
Musella A et al. Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum. 2010 Neuroscience pmid:20219639
Hurst DP et al. A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor. 2010 J. Biol. Chem. pmid:20220143
Kozono S et al. Involvement of the endocannabinoid system in periodontal healing. 2010 Biochem. Biophys. Res. Commun. pmid:20233580
Muccioli GG Endocannabinoid biosynthesis and inactivation, from simple to complex. 2010 Drug Discov. Today pmid:20304091
Kvasnicka T [The endocannabinoid system and interference with thrombogenesis]. 2010 Vnitr Lek pmid:20329583
Frampton G et al. Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling. 2010 Exp. Cell Res. pmid:20347808
Kim J and Alger BE Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. 2010 Nat. Neurosci. pmid:20348918
Minkkilä A et al. Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors. 2010 Curr Top Med Chem pmid:20370710
Hoot MR et al. Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. 2010 Brain Res. pmid:20380816
Maccarrone M et al. Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA. 2010 Neuropsychopharmacology pmid:20393458
Ying-Ying Y and Lin HC Endocannabinoids and non-endocannabinoid fatty acid amides in cirrhosis. 2010 Liver Int. pmid:20408944
Mukhopadhyay B et al. Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. 2010 J. Biol. Chem. pmid:20410309
Spradley JM et al. Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. 2010 Pharmacol. Res. pmid:20416378
Placzek EA et al. Lipidomic metabolism analysis of the endogenous cannabinoid anandamide (N-arachidonylethanolamide). 2010 J Pharm Biomed Anal pmid:20417049
Jumpertz R et al. Circulating endocannabinoids and N-acyl-ethanolamides in patients with sleep apnea--specific role of oleoylethanolamide. 2010 Exp. Clin. Endocrinol. Diabetes pmid:20429051
Jyotaki M et al. Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors. 2010 Endocr. J. pmid:20431269
Maccarrone M Endocannabinoid-binding receptors: old friends and new comers. 2010 Curr. Med. Chem. pmid:20441559
Massa F et al. Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. 2010 J. Neurosci. pmid:20445053
Bari M et al. Characterization of the endocannabinoid system in mouse embryonic stem cells. 2011 Stem Cells Dev. pmid:20446814
Skonberg C et al. Pitfalls in the sample preparation and analysis of N-acylethanolamines. 2010 J. Lipid Res. pmid:20447930
Bardell TK and Barker EL Activation of TRPC6 channels promotes endocannabinoid biosynthesis in neuronal CAD cells. 2010 Neurochem. Int. pmid:20466028
Naccarato M et al. Possible Anandamide and Palmitoylethanolamide involvement in human stroke. 2010 Lipids Health Dis pmid:20470384
Haj-Dahmane S and Shen RY Regulation of plasticity of glutamate synapses by endocannabinoids and the cyclic-AMP/protein kinase A pathway in midbrain dopamine neurons. 2010 J. Physiol. (Lond.) pmid:20498231
Smith SL and Rasmussen EB Effects of 2-AG on the reinforcing properties of wheel activity in obese and lean Zucker rats. 2010 Behav Pharmacol pmid:20512031
Shimizu T et al. Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats. 2010 Eur. J. Pharmacol. pmid:20519139
Mecs L et al. Peripheral antinociceptive effect of 2-arachidonoyl-glycerol and its interaction with endomorphin-1 in arthritic rat ankle joints. 2010 Clin. Exp. Pharmacol. Physiol. pmid:20529093
Suárez J et al. Endocannabinoid system in the adult rat circumventricular areas: an immunohistochemical study. 2010 J. Comp. Neurol. pmid:20533360
Urbanski MJ et al. Endocannabinoid-mediated synaptically evoked suppression of GABAergic transmission in the cerebellar cortex. 2010 Neuroscience pmid:20553815
Mukhopadhyay P et al. CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. 2010 Br. J. Pharmacol. pmid:20590569
Ho WS et al. Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex. 2010 Br. J. Pharmacol. pmid:20590576
Gutierrez-Lopez MD et al. Involvement of 2-arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine. 2010 Br. J. Pharmacol. pmid:20590579
Breunig E et al. The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. 2010 J. Neurosci. pmid:20592217
Fino E et al. Distinct coincidence detectors govern the corticostriatal spike timing-dependent plasticity. 2010 J. Physiol. (Lond.) pmid:20603333
Keown OP et al. 2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors. 2010 Br J Clin Pharmacol pmid:20653671
Marrs WR et al. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. 2010 Nat. Neurosci. pmid:20657592
Muccioli GG et al. The endocannabinoid system links gut microbiota to adipogenesis. 2010 Mol. Syst. Biol. pmid:20664638
Sagar DR et al. Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. 2010 Arthritis Rheum. pmid:20722027
Fonseca BM et al. The endocannabinoid 2-arachidonoylglycerol (2-AG) and metabolizing enzymes during rat fetoplacental development: a role in uterine remodelling. 2010 Int. J. Biochem. Cell Biol. pmid:20727980
Higuchi S et al. Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors. 2011 Behav. Brain Res. pmid:20817042
Jiang S et al. Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. 2010 J. Biol. Chem. pmid:20826813
Gomez O et al. The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation. 2010 Glia pmid:20878765
Evagorou A et al. Hydrolysis of 2-arachidonoylglycerol in Tetrahymena thermophila. Identification and partial characterization of a Monoacylglycerol Lipase-like enzyme. 2010 Eur. J. Protistol. pmid:20889319
Farkas I et al. Retrograde endocannabinoid signaling reduces GABAergic synaptic transmission to gonadotropin-releasing hormone neurons. 2010 Endocrinology pmid:20926585
Lichtman AH et al. Endocannabinoid overload. 2010 Mol. Pharmacol. pmid:20952498
Yasuo S et al. Localization of an endocannabinoid system in the hypophysial pars tuberalis and pars distalis of man. 2010 Cell Tissue Res. pmid:20957495
Keimpema E et al. Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. 2010 J. Neurosci. pmid:20962221
Ludányi A et al. Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. 2011 Neuroscience pmid:21035522
Xie S et al. Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. 2010 Chem. Res. Toxicol. pmid:21049984
Higuchi S et al. Reducing acyl migration during purification of 2-arachidonoylglycerol from biological samples before gas chromatography mass spectrometry analysis. 2010 Anal Sci pmid:21079352
Katona I Endocannabinoid receptors: CNS localization of the CB₁ cannabinoid receptor. 2009 Curr Top Behav Neurosci pmid:21104380
Sun X and Dey SK Cannabinoid/Endocannabinoid signaling impact on early pregnancy events. 2009 Curr Top Behav Neurosci pmid:21104387
De Petrocellis L et al. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. 2011 Br. J. Pharmacol. pmid:21175579
Jumpertz R et al. Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. 2011 J. Clin. Endocrinol. Metab. pmid:21177788
Di Marzo V Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. 2011 Nat. Neurosci. pmid:21187849