2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Weight Gain D015430 101 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Glioma D005910 112 associated lipids
Obesity D009765 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Nervous System Diseases D009422 37 associated lipids
Brain Edema D001929 20 associated lipids
Starvation D013217 47 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

Download all related citations
Per page 10 20 50 100 | Total 1060
Authors Title Published Journal PubMed Link
Ryberg E et al. The orphan receptor GPR55 is a novel cannabinoid receptor. 2007 Br. J. Pharmacol. pmid:17876302
Sakamoto Y et al. Clinical responses and improvement of some laboratory parameters following polymyxin B-immobilized fiber treatment in septic shock. 2007 Sep-Oct ASAIO J. pmid:17885340
Duan Y et al. Inhibition of [3H]batrachotoxinin A-20alpha-benzoate binding to sodium channels and sodium channel function by endocannabinoids. 2008 Neurochem. Int. pmid:17888543
Hillard CJ et al. Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. 2007 Br. J. Pharmacol. pmid:17891162
Opitz CA et al. Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells. 2007 FEBS Lett. pmid:17904123
Shiratsuchi A et al. Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis. 2008 Immunol. Cell Biol. pmid:17909562
Tanikawa T et al. Induction of preferential chemotaxis of unstimulated B-lymphocytes by 2-arachidonoylglycerol in immunized mice. 2007 Microbiol. Immunol. pmid:17951991
Rimmerman N et al. Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line. 2008 Br. J. Pharmacol. pmid:17965731
Mukhopadhyay S and Tulis DA Endocannabinoid regulation of matrix metalloproteinases: implications in ischemic stroke. 2007 Cardiovasc Hematol Agents Med Chem pmid:17979695
Dainese E et al. Modulation of the endocannabinoid system by lipid rafts. 2007 Curr. Med. Chem. pmid:17979719
Muccioli GG and Stella N An optimized GC-MS method detects nanomolar amounts of anandamide in mouse brain. 2008 Anal. Biochem. pmid:17981259
Thiemann G et al. The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization. 2008 Behav. Brain Res. pmid:17988751
Béquet F et al. CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus. 2007 Eur. J. Neurosci. pmid:18052990
Hill MN et al. Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. 2008 Hippocampus pmid:18058925
Adermark L and Lovinger DM Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:18077376
Marrs W and Stella N 2-AG + 2 new players = forecast for therapeutic advances. 2007 Chem. Biol. pmid:18096497
Imming P Fatty pain cures. 2007 Chem. Biol. pmid:18096498
Blankman JL et al. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. 2007 Chem. Biol. pmid:18096503
King AR et al. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. 2007 Chem. Biol. pmid:18096504
Maccarrone M et al. Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. 2008 Nat. Neurosci. pmid:18204441
Shimizu T and Yokotani K Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats. 2008 Eur. J. Pharmacol. pmid:18234185
Starowicz KM et al. Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet. 2008 Obesity (Silver Spring) pmid:18239598
Guindon J and Hohmann AG A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism. 2008 Br. J. Pharmacol. pmid:18297102
Hu SS et al. Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity. 2008 Br. J. Pharmacol. pmid:18297109
Oláh M et al. The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG. 2008 Mol. Cell. Endocrinol. pmid:18308464
Hill MN et al. Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. 2008 Pharmacopsychiatry pmid:18311684
Friedman SL and Nieto N Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors. 2008 Cell Metab. pmid:18316020
Jeong WI et al. Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. 2008 Cell Metab. pmid:18316028
Vellani V et al. Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin. 2008 Neuropharmacology pmid:18329052
Palkovits M et al. Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain. 2008 Neuroscience pmid:18343585
Engeli S et al. Peripheral endocannabinoid system activity in patients treated with sibutramine. 2008 Obesity (Silver Spring) pmid:18356837
Rubio M et al. CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. 2008 Neuropharmacology pmid:18371990
Awumey EM et al. Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18375719
Di Marzo V and Maccarrone M FAAH and anandamide: is 2-AG really the odd one out? 2008 Trends Pharmacol. Sci. pmid:18394720
Solinas M et al. The endocannabinoid system in brain reward processes. 2008 Br. J. Pharmacol. pmid:18414385
Richardson D et al. Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. 2008 Arthritis Res. Ther. pmid:18416822
Bisogno T Endogenous cannabinoids: structure and metabolism. 2008 J. Neuroendocrinol. pmid:18426492
Nomura DK et al. Activation of the endocannabinoid system by organophosphorus nerve agents. 2008 Nat. Chem. Biol. pmid:18438404
Di Marzo V Endocannabinoids: synthesis and degradation. 2008 Rev. Physiol. Biochem. Pharmacol. pmid:18481028
Pertwee RG Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. 2008 Addict Biol pmid:18482430
Sheinin A et al. Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. 2008 J. Neurophysiol. pmid:18497350
Zhang J and Chen C Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. 2008 J. Biol. Chem. pmid:18534982
Di Filippo M et al. Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. 2008 J. Neurol. Neurosurg. Psychiatr. pmid:18535023
Nabemoto M et al. Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha. 2008 Eur. J. Pharmacol. pmid:18539271
Palmer JA et al. Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. 2008 Neuroscience pmid:18541380
Qin N et al. TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. 2008 J. Neurosci. pmid:18550765
Motaghedi R and McGraw TE The CB1 endocannabinoid system modulates adipocyte insulin sensitivity. 2008 Obesity (Silver Spring) pmid:18551116
Endsley MP et al. Expression and function of fatty acid amide hydrolase in prostate cancer. 2008 Int. J. Cancer pmid:18566995
Rockwell CE et al. A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells. 2008 Biochem. Pharmacol. pmid:18571623
Njie YF et al. Aqueous humor outflow effects of 2-arachidonylglycerol. 2008 Exp. Eye Res. pmid:18597752