2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Jones BR et al. | Surrogate matrix and surrogate analyte approaches for definitive quantitation of endogenous biomolecules. | 2012 | Bioanalysis | pmid:23088461 |
Hauer D et al. | Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression. | 2012 | Rev Neurosci | pmid:23006898 |
Psychoyos D et al. | Cannabinoid receptor 1 signaling in embryo neurodevelopment. | 2012 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:22311661 |
Alger BE | Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know. | 2012 | J. Physiol. (Lond.) | pmid:22289914 |
Ueda N et al. | Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol. | 2011 Jan-Feb | Biofactors | pmid:21328621 |
Frazier CJ | Key questions of endocannabinoid signalling in the CNS: which, where and when? | 2011 | J. Physiol. (Lond.) | pmid:22001725 |
Nomura DK et al. | Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. | 2011 | Science | pmid:22021672 |
Muppidi JR et al. | Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. | 2011 | J. Exp. Med. | pmid:21875957 |
Du H et al. | Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. | 2011 | Br. J. Pharmacol. | pmid:21501147 |
Raman P et al. | 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. | 2011 | Mol. Pharmacol. | pmid:21511917 |
Hofmann ME et al. | Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. | 2011 | J. Physiol. (Lond.) | pmid:21646412 |
Sarmad S et al. | Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. | 2011 | J. Neurochem. | pmid:21375532 |
Howlett AC et al. | Endocannabinoid tone versus constitutive activity of cannabinoid receptors. | 2011 | Br. J. Pharmacol. | pmid:21545414 |
Carr RL et al. | Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. | 2011 | Toxicol. Sci. | pmid:21507991 |
Vecchio AJ and Malkowski MG | The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. | 2011 | J. Biol. Chem. | pmid:21489986 |
Balenga NA et al. | GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. | 2011 | Cell Res. | pmid:21467997 |
Chen X et al. | Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults. | 2011 | Neuroscience | pmid:21256197 |
Yoshida T et al. | Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21282604 |
Liao HT et al. | Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition. | 2011 | Br. J. Pharmacol. | pmid:21232043 |
Soderstrom K et al. | Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness. | 2011 | BMC Neurosci | pmid:21211022 |
Petrosino S et al. | Alteration of the endocannabinoid system in mouse brain during prion disease. | 2011 | Neuroscience | pmid:21195746 |
Guindon J et al. | Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. | 2011 | Br. J. Pharmacol. | pmid:21198549 |
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Brizzi A et al. | Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor. | 2011 | J. Med. Chem. | pmid:22044209 |
Yoshino H et al. | Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. | 2011 | J. Physiol. (Lond.) | pmid:21807615 |
Chouinard F et al. | The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis. | 2011 | J. Immunol. | pmid:21278347 |
Khasabova IA et al. | Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. | 2011 | Pharmacol. Res. | pmid:21440630 |
Catanzaro G et al. | Effect of capacitation on the endocannabinoid system of mouse sperm. | 2011 | Mol. Cell. Endocrinol. | pmid:21723369 |