2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sugiura T and Waku K | Cannabinoid receptors and their endogenous ligands. | 2002 | J. Biochem. | pmid:12097154 |
Jordà MA et al. | Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol. | 2002 | Blood | pmid:11929767 |
Kirkham TC et al. | Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. | 2002 | Br. J. Pharmacol. | pmid:12055133 |
Maccarrone M et al. | Endocannabinoid degradation, endotoxic shock and inflammation. | 2002 | Curr Drug Targets Inflamm Allergy | pmid:14561206 |
Darmani NA | The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids. | 2002 | J. Pharmacol. Exp. Ther. | pmid:11752094 |
González S et al. | Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine. | 2002 | Brain Res. | pmid:12393235 |
Rouzer CA et al. | Chemical stability of 2-arachidonylglycerol under biological conditions. | 2002 | Chem. Phys. Lipids | pmid:12270674 |
Bisogno T et al. | Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications. | 2002 | Curr. Pharm. Des. | pmid:11945157 |
Lichtman AH et al. | Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12065702 |
Dinh TP et al. | A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. | 2002 | Chem. Phys. Lipids | pmid:12505697 |
Kojima S et al. | Contractile response to a cannabimimetic eicosanoid, 2-arachidonoylglycerol, of longitudinal smooth muscle from the guinea-pig distal colon in vitro. | 2002 | Eur. J. Pharmacol. | pmid:12063081 |
Razdan RK and Mahadevan A | Recent advances in the synthesis of endocannabinoid related ligands. | 2002 | Chem. Phys. Lipids | pmid:12505687 |
Kunos G et al. | The quest for a vascular endothelial cannabinoid receptor. | 2002 | Chem. Phys. Lipids | pmid:12505689 |
Schmid HH et al. | Cell signaling by endocannabinoids and their congeners: questions of selectivity and other challenges. | 2002 | Chem. Phys. Lipids | pmid:12505695 |
Kozak KR et al. | Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. | 2002 | J. Biol. Chem. | pmid:12244105 |
Mechoulam R et al. | Cannabinoids and brain injury: therapeutic implications. | 2002 | Trends Mol Med | pmid:11815270 |
Dinh TP et al. | Brain monoglyceride lipase participating in endocannabinoid inactivation. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12136125 |
Matias I et al. | Presence and regulation of the endocannabinoid system in human dendritic cells. | 2002 | Eur. J. Biochem. | pmid:12153574 |
Gubellini P et al. | Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. | 2002 | J. Neurosci. | pmid:12177188 |
Kozak KR et al. | 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. | 2002 | J. Biol. Chem. | pmid:11956198 |