2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hanlon EC et al. | Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. | 2016 | Sleep | pmid:26612385 |
Motobe T et al. | Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome. | 2004 | Shock | pmid:14676677 |
Wang SL et al. | [Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells]. | 2017 | Sheng Li Xue Bao | pmid:29063116 |
Hillard CJ | Stress regulates endocannabinoid-CB1 receptor signaling. | 2014 | Semin. Immunol. | pmid:24882055 |
Sugiura T | [2-Arachidonoylglycerol: an endogenous cannabinoid receptor ligand]. | 2007 | Seikagaku | pmid:17763698 |
Karsak M et al. | Attenuation of allergic contact dermatitis through the endocannabinoid system. | 2007 | Science | pmid:17556587 |
Nomura DK et al. | Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. | 2011 | Science | pmid:22021672 |
Stella N | Cell biology. Anatomy of prostaglandin signals. | 2011 | Science | pmid:22076368 |
Marsicano G et al. | CB1 cannabinoid receptors and on-demand defense against excitotoxicity. | 2003 | Science | pmid:14526074 |
Miller MR et al. | Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. | 2016 | Science | pmid:26989199 |