2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Sagar DR et al. | Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. | 2010 | Arthritis Rheum. | pmid:20722027 |
Ying-Ying Y and Lin HC | Endocannabinoids and non-endocannabinoid fatty acid amides in cirrhosis. | 2010 | Liver Int. | pmid:20408944 |
Spradley JM et al. | Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. | 2010 | Pharmacol. Res. | pmid:20416378 |
Naccarato M et al. | Possible Anandamide and Palmitoylethanolamide involvement in human stroke. | 2010 | Lipids Health Dis | pmid:20470384 |
Mukhopadhyay P et al. | CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. | 2010 | Br. J. Pharmacol. | pmid:20590569 |
Gutierrez-Lopez MD et al. | Involvement of 2-arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine. | 2010 | Br. J. Pharmacol. | pmid:20590579 |
Muccioli GG et al. | The endocannabinoid system links gut microbiota to adipogenesis. | 2010 | Mol. Syst. Biol. | pmid:20664638 |
Suárez J et al. | Endocannabinoid system in the adult rat circumventricular areas: an immunohistochemical study. | 2010 | J. Comp. Neurol. | pmid:20533360 |
Jumpertz R et al. | Circulating endocannabinoids and N-acyl-ethanolamides in patients with sleep apnea--specific role of oleoylethanolamide. | 2010 | Exp. Clin. Endocrinol. Diabetes | pmid:20429051 |
Jyotaki M et al. | Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors. | 2010 | Endocr. J. | pmid:20431269 |
Mukhopadhyay B et al. | Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. | 2010 | J. Biol. Chem. | pmid:20410309 |
Maccarrone M | Endocannabinoid-binding receptors: old friends and new comers. | 2010 | Curr. Med. Chem. | pmid:20441559 |
Skonberg C et al. | Pitfalls in the sample preparation and analysis of N-acylethanolamines. | 2010 | J. Lipid Res. | pmid:20447930 |
Sugiura T | Physiological roles of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. | 2009 Jan-Feb | Biofactors | pmid:19319851 |
Wang J and Ueda N | Biology of endocannabinoid synthesis system. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19126434 |
Vignali M et al. | The endocannabinoid anandamide inhibits potassium conductance in rat cortical astrocytes. | 2009 | Glia | pmid:19031444 |
Dowie MJ et al. | Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. | 2009 | Neuroscience | pmid:19524019 |
Maeda N et al. | Increased serum anandamide level at ruptured plaque site in patients with acute myocardial infarction. | 2009 | Fundam Clin Pharmacol | pmid:19527302 |
Straiker A and Mackie K | Cannabinoid signaling in inhibitory autaptic hippocampal neurons. | 2009 | Neuroscience | pmid:19501632 |
Kinsey SG et al. | Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19502530 |
Guasti L et al. | Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain. | 2009 | Mol Pain | pmid:19570201 |
Grimaldi P et al. | The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19541620 |
Batetta B et al. | Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats. | 2009 | J. Nutr. | pmid:19549757 |
Astarita G et al. | Targeted lipidomics as a tool to investigate endocannabinoid function. | 2009 | Int. Rev. Neurobiol. | pmid:19607960 |
Yates ML and Barker EL | Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonoylglycerol. | 2009 | Mol. Pharmacol. | pmid:19389920 |
Hill MN et al. | Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. | 2009 | Psychoneuroendocrinology | pmid:19394765 |
Guindon J and Hohmann AG | The endocannabinoid system and pain. | 2009 | CNS Neurol Disord Drug Targets | pmid:19839937 |
Marco EM and Viveros MP | The critical role of the endocannabinoid system in emotional homeostasis: avoiding excess and deficiencies. | 2009 | Mini Rev Med Chem | pmid:19929814 |
Katona I | Endocannabinoid receptors: CNS localization of the CBâ‚ cannabinoid receptor. | 2009 | Curr Top Behav Neurosci | pmid:21104380 |
Sun X and Dey SK | Cannabinoid/Endocannabinoid signaling impact on early pregnancy events. | 2009 | Curr Top Behav Neurosci | pmid:21104387 |
Alvarez-Jaimes L et al. | Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats. | 2009 | J. Neurochem. | pmid:19650871 |
Maccarrone M et al. | Lipid rafts regulate 2-arachidonoylglycerol metabolism and physiological activity in the striatum. | 2009 | J. Neurochem. | pmid:19187444 |
Bisogno T et al. | Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. | 2009 | ChemMedChem | pmid:19266526 |
Kreutz S et al. | 2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal-cannabidiol-sensitive receptors on microglial cells. | 2009 | Glia | pmid:18837048 |
Di Marzo V et al. | Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors. | 2009 | Diabetologia | pmid:18972095 |
Avraham Y et al. | Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice. | 2009 | Br. J. Pharmacol. | pmid:19764982 |
Urbanski MJ et al. | Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. | 2009 | Synapse | pmid:19347961 |
Straiker A et al. | Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. | 2009 | Mol. Pharmacol. | pmid:19767452 |
Bajo M et al. | Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands. | 2009 | J. Neurosci. Res. | pmid:18816788 |
Bisogno T et al. | Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. | 2009 | Biochim. Biophys. Acta | pmid:19027877 |
Long JZ et al. | Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. | 2009 | Nat. Chem. Biol. | pmid:19029917 |
Tsuyama S et al. | Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. | 2009 | Nutr Neurosci | pmid:19622239 |
Schlosburg JE et al. | Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation. | 2009 | AAPS J | pmid:19184452 |
Koppel J et al. | Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study. | 2009 | Lipids Health Dis | pmid:19144193 |
Nyilas R et al. | Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia. | 2009 | Eur. J. Neurosci. | pmid:19453631 |
Garcia-Ovejero D et al. | The endocannabinoid system is modulated in response to spinal cord injury in rats. | 2009 | Neurobiol. Dis. | pmid:18930143 |
Wakley AA and Rasmussen EB | Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats. | 2009 | Pharmacol. Biochem. Behav. | pmid:19602424 |
Prusakiewicz JJ et al. | Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid. | 2009 | Biochemistry | pmid:19603831 |
Long JZ et al. | Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19918051 |
Bowman AL and Makriyannis A | Refined homology model of monoacylglycerol lipase: toward a selective inhibitor. | 2009 | J. Comput. Aided Mol. Des. | pmid:19543978 |
Long JZ et al. | Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. | 2009 | Chem. Biol. | pmid:19635411 |
Patel S et al. | Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. | 2009 | Neuropsychopharmacology | pmid:19675536 |
Pan B et al. | Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19666749 |
Li Q and Burrell BD | Two forms of long-term depression in a polysynaptic pathway in the leech CNS: one NMDA receptor-dependent and the other cannabinoid-dependent. | 2009 | J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. | pmid:19657662 |
Morgan NH et al. | Functional CB2 type cannabinoid receptors at CNS synapses. | 2009 | Neuropharmacology | pmid:19616018 |
Izzo AA et al. | Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding. | 2009 | Br. J. Pharmacol. | pmid:19371345 |
Bermúdez-Silva FJ et al. | The role of the pancreatic endocannabinoid system in glucose metabolism. | 2009 | Best Pract. Res. Clin. Endocrinol. Metab. | pmid:19285263 |
Schroeder C et al. | Circulating endocannabinoid concentrations during orthostatic stress. | 2009 | Clin. Auton. Res. | pmid:19756829 |
Catani MV et al. | Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. | 2009 | J. Mol. Med. | pmid:18820887 |
Zhang SY et al. | Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. | 2009 | J. Neurosci. | pmid:19846710 |
Thors L and Fowler CJ | Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids. | 2009 | Eur. J. Pharmacol. | pmid:19715690 |
Won YJ et al. | Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons. | 2009 | J. Neurosci. | pmid:19864572 |
Maison P et al. | BDNF regulates neuronal sensitivity to endocannabinoids. | 2009 | Neurosci. Lett. | pmid:19818836 |
Di Marzo V et al. | Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. | 2009 | Eur. J. Endocrinol. | pmid:19745037 |
Gkini E et al. | Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase. | 2009 | Platelets | pmid:19811221 |
Jiang LS et al. | Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. | 2009 | Cardiovasc. Res. | pmid:19074161 |
Avraham Y et al. | 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the evolution of experimental cholestatic liver disease. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18771906 |
Baldassarri S et al. | The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors. | 2008 | J. Thromb. Haemost. | pmid:18647220 |
Ortar G et al. | Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. | 2008 | Eur J Med Chem | pmid:17452063 |
Shiratsuchi A et al. | Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis. | 2008 | Immunol. Cell Biol. | pmid:17909562 |
Duan Y et al. | Inhibition of [3H]batrachotoxinin A-20alpha-benzoate binding to sodium channels and sodium channel function by endocannabinoids. | 2008 | Neurochem. Int. | pmid:17888543 |
Rimmerman N et al. | Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line. | 2008 | Br. J. Pharmacol. | pmid:17965731 |
Hill MN et al. | Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. | 2008 | Hippocampus | pmid:18058925 |
Maccarrone M et al. | Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. | 2008 | Nat. Neurosci. | pmid:18204441 |
Starowicz KM et al. | Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet. | 2008 | Obesity (Silver Spring) | pmid:18239598 |
Shimizu T and Yokotani K | Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats. | 2008 | Eur. J. Pharmacol. | pmid:18234185 |
Moreira FA et al. | Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. | 2008 | Neuropharmacology | pmid:17709120 |
Tam J et al. | The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. | 2008 | FASEB J. | pmid:17704191 |
Chiu CQ and Castillo PE | Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. | 2008 | Neuropharmacology | pmid:17706254 |
Vellani V et al. | Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin. | 2008 | Neuropharmacology | pmid:18329052 |
Guindon J and Hohmann AG | A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism. | 2008 | Br. J. Pharmacol. | pmid:18297102 |
Hu SS et al. | Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity. | 2008 | Br. J. Pharmacol. | pmid:18297109 |
Friedman SL and Nieto N | Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors. | 2008 | Cell Metab. | pmid:18316020 |
Hill MN et al. | Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. | 2008 | Pharmacopsychiatry | pmid:18311684 |
Jeong WI et al. | Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. | 2008 | Cell Metab. | pmid:18316028 |
Palkovits M et al. | Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain. | 2008 | Neuroscience | pmid:18343585 |
Ortar G et al. | Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. | 2008 | J. Med. Chem. | pmid:18831576 |
Hoover HS et al. | Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18657971 |
Marinelli S et al. | The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons. | 2008 | J. Neurosci. | pmid:19074027 |
Lu TS et al. | Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. | 2008 | J. Immunol. | pmid:18941231 |
Sheinin A et al. | Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. | 2008 | J. Neurophysiol. | pmid:18497350 |
Zhang J and Chen C | Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. | 2008 | J. Biol. Chem. | pmid:18534982 |
Nabemoto M et al. | Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha. | 2008 | Eur. J. Pharmacol. | pmid:18539271 |
Endsley MP et al. | Expression and function of fatty acid amide hydrolase in prostate cancer. | 2008 | Int. J. Cancer | pmid:18566995 |
Rockwell CE et al. | A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells. | 2008 | Biochem. Pharmacol. | pmid:18571623 |
Njie YF et al. | Aqueous humor outflow effects of 2-arachidonylglycerol. | 2008 | Exp. Eye Res. | pmid:18597752 |
Muccioli GG and Stella N | An optimized GC-MS method detects nanomolar amounts of anandamide in mouse brain. | 2008 | Anal. Biochem. | pmid:17981259 |
Motaghedi R and McGraw TE | The CB1 endocannabinoid system modulates adipocyte insulin sensitivity. | 2008 | Obesity (Silver Spring) | pmid:18551116 |
Thiemann G et al. | The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization. | 2008 | Behav. Brain Res. | pmid:17988751 |
Burston JJ et al. | N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18682568 |