2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Haj-Dahmane S et al. | Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses. | 2018 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29531087 |
Atsak P et al. | Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22331883 |
Piomelli D et al. | Structural determinants for recognition and translocation by the anandamide transporter. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10318965 |
Chicca A et al. | Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28584105 |
Morena M et al. | Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25489086 |
Adermark L and Lovinger DM | Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077376 |
Cristino L et al. | Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23630288 |
Keimpema E et al. | Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23319656 |
Alhouayek M et al. | Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24101490 |
Lauckner JE et al. | The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16365309 |
Iannotti FA et al. | The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24927567 |
Yoshida T et al. | Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21282604 |
Witting A et al. | P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:14976257 |
Long JZ et al. | Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19918051 |
Buczynski MW et al. | Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26755579 |
Ogasawara D et al. | Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26668358 |
Dinh TP et al. | Brain monoglyceride lipase participating in endocannabinoid inactivation. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12136125 |
Pertwee RG | Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications. | 2014 | Proc Nutr Soc | pmid:24135210 |
Burston JJ and Woodhams SG | Endocannabinoid system and pain: an introduction. | 2014 | Proc Nutr Soc | pmid:24148358 |
Karabowicz P et al. | [Role of endocannabinoid 2-arachidonoylglycerol in the physiology and pathophysiology of the cardiovascular system]. | 2014 | Postepy Hig Med Dosw (Online) | pmid:24934539 |
Jehle J et al. | Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. | 2018 | PLoS ONE | pmid:29813086 |
Martins CJ et al. | Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. | 2015 | PLoS ONE | pmid:26561012 |
Smith M et al. | The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. | 2015 | PLoS ONE | pmid:26414859 |
Fagundo AB et al. | Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. | 2013 | PLoS ONE | pmid:23840456 |
Chon SH et al. | Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity. | 2012 | PLoS ONE | pmid:22937137 |
Zhang L et al. | Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase. | 2011 | PLoS ONE | pmid:21305054 |
Wang DJ et al. | Cytosolic phospholipase A2 alpha/arachidonic acid signaling mediates depolarization-induced suppression of excitation in the cerebellum. | 2012 | PLoS ONE | pmid:22927908 |
Nicholson J et al. | Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. | 2015 | PLoS ONE | pmid:25835291 |
Higuchi S et al. | Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. | 2012 | PLoS ONE | pmid:22737214 |
Özdemir B et al. | Endocannabinoids and inflammatory response in periodontal ligament cells. | 2014 | PLoS ONE | pmid:25226300 |
Kallendrusch S et al. | Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage. | 2012 | PLoS ONE | pmid:23284665 |
Lafourcade M et al. | Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. | 2007 | PLoS ONE | pmid:17684555 |
Chanda D et al. | Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH. | 2013 | PLoS ONE | pmid:23894352 |
Pellkofer HL et al. | The major brain endocannabinoid 2-AG controls neuropathic pain and mechanical hyperalgesia in patients with neuromyelitis optica. | 2013 | PLoS ONE | pmid:23951176 |
Costola-de-Souza C et al. | Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice. | 2013 | PLoS ONE | pmid:24204926 |
Starowicz K et al. | Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. | 2013 | PLoS ONE | pmid:23573230 |
Zygmunt PM et al. | Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. | 2013 | PLoS ONE | pmid:24312564 |
Pava MJ et al. | Endocannabinoid modulation of cortical up-states and NREM sleep. | 2014 | PLoS ONE | pmid:24520411 |
Cippitelli A et al. | Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. | 2011 | PLoS ONE | pmid:22140525 |
Pastor A et al. | A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women. | 2016 | PLoS ONE | pmid:26849214 |
Jalin AM et al. | Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity. | 2015 | PLoS ONE | pmid:26517721 |
Kita Y et al. | Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2. | 2015 | PLoS ONE | pmid:26196692 |
Brantl SA et al. | Activation of platelets by the endocannabinoids 2-arachidonoylglycerol and virodhamine is mediated by their conversion to arachidonic acid and thromboxane A2, not by activation of cannabinoid receptors. | 2014 | Platelets | pmid:24102401 |
Brantl SA et al. | Mechanism of platelet activation induced by endocannabinoids in blood and plasma. | 2014 | Platelets | pmid:23789792 |
Gkini E et al. | Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase. | 2009 | Platelets | pmid:19811221 |
Brocato B et al. | Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. | 2013 | Placenta | pmid:24008071 |
Pacioni G et al. | Truffles contain endocannabinoid metabolic enzymes and anandamide. | 2015 | Phytochemistry | pmid:25433633 |
Argueta DA and DiPatrizio NV | Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity. | 2017 | Physiol. Behav. | pmid:28065722 |
Thompson Z et al. | Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes. | 2017 | Physiol. Behav. | pmid:28017680 |
Sticht MA et al. | 2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus. | 2013 | Physiol. Behav. | pmid:23958470 |
Reisenberg M et al. | The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108545 |
Melis M and Pistis M | Hub and switches: endocannabinoid signalling in midbrain dopamine neurons. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108546 |
Skaper SD and Di Marzo V | Endocannabinoids in nervous system health and disease: the big picture in a nutshell. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108539 |
Di Marzo V and De Petrocellis L | Why do cannabinoid receptors have more than one endogenous ligand? | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108541 |
Puighermanal E et al. | Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108544 |
Starowicz K and Przewlocka B | Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108547 |
Rani Sagar D et al. | Dynamic changes to the endocannabinoid system in models of chronic pain. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108548 |
Hill MN et al. | Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. | 2008 | Pharmacopsychiatry | pmid:18311684 |
Haruna T et al. | The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice. | 2017 | Pharmacology | pmid:28214870 |
Blankman JL and Cravatt BF | Chemical probes of endocannabinoid metabolism. | 2013 | Pharmacol. Rev. | pmid:23512546 |
Stanley CP and O'Sullivan SE | Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries. | 2014 | Pharmacol. Res. | pmid:24548820 |
Eisenstein SA et al. | A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. | 2010 | Pharmacol. Res. | pmid:20044005 |
Deshmukh RR and Sharma PL | Stimulation of accumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats. | 2012 | Pharmacol. Res. | pmid:22728691 |
Khasabova IA et al. | JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. | 2014 | Pharmacol. Res. | pmid:25304184 |
Navarria A et al. | The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. | 2014 | Pharmacol. Res. | pmid:24861565 |
Spradley JM et al. | Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. | 2010 | Pharmacol. Res. | pmid:20416378 |
Leishman E et al. | Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. | 2016 | Pharmacol. Res. | pmid:27109320 |
Guindon J et al. | Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. | 2013 | Pharmacol. Res. | pmid:23127915 |
Sciolino NR et al. | Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. | 2011 | Pharmacol. Res. | pmid:21600985 |
Stefano GB et al. | 2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1. | 2000 | Pharmacol. Res. | pmid:10987990 |
Malek N et al. | The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain. | 2016 | Pharmacol. Res. | pmid:27326920 |
Fowler CJ and Ghafouri N | Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? | 2008 | Pharmacol. Res. | pmid:18675915 |
Nicolussi S et al. | Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice. | 2014 | Pharmacol. Res. | pmid:24412246 |
Khasabova IA et al. | Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. | 2011 | Pharmacol. Res. | pmid:21440630 |
Bakas T et al. | The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABA receptors. | 2017 | Pharmacol. Res. | pmid:28249817 |
Pagano E et al. | Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis. | 2017 | Pharmacol. Res. | pmid:28193521 |
Straiker A et al. | Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model. | 2015 | Pharmacol. Res. | pmid:26211948 |
Imperatore R et al. | Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation. | 2016 | Pharmacol. Res. | pmid:27436148 |
Pérez-Morales M et al. | 2-AG into the lateral hypothalamus increases REM sleep and cFos expression in melanin concentrating hormone neurons in rats. | 2013 | Pharmacol. Biochem. Behav. | pmid:23603032 |
Wakley AA and Rasmussen EB | Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats. | 2009 | Pharmacol. Biochem. Behav. | pmid:19602424 |
Carrasquer A et al. | Functional consequences of nonsynonymous single nucleotide polymorphisms in the CB2 cannabinoid receptor. | 2010 | Pharmacogenet. Genomics | pmid:20124950 |
den Boon FS et al. | Endocannabinoids produced upon action potential firing evoke a Cl(-) current via type-2 cannabinoid receptors in the medial prefrontal cortex. | 2014 | Pflugers Arch. | pmid:24671573 |
Carloni S et al. | Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. | 2012 | Pediatr. Res. | pmid:22821058 |
Rea K et al. | Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats. | 2013 | Pain | pmid:23414578 |
Telleria-Diaz A et al. | Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids. | 2010 | Pain | pmid:19879047 |
Bradshaw H | CB1-induced side effects of specific COX-2 inhibitors: a feature, not a bug. | 2010 | Pain | pmid:19913999 |
La Porta C et al. | Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain. | 2015 | Pain | pmid:26067584 |
Vujic N et al. | Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice. | 2017 | Oncotarget | pmid:28380440 |
Echigo R et al. | Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells. | 2012 | Oncol. Rep. | pmid:22842590 |
Orellana-Serradell O et al. | Proapoptotic effect of endocannabinoids in prostate cancer cells. | 2015 | Oncol. Rep. | pmid:25606819 |
Bernabò N et al. | Systems biology analysis of the endocannabinoid system reveals a scale-free network with distinct roles for anandamide and 2-arachidonoylglycerol. | 2013 | OMICS | pmid:24117401 |
Haas MJ et al. | Inhibition of apolipoprotein A-I gene expression by obesity-associated endocannabinoids. | 2012 | Obesity (Silver Spring) | pmid:22016100 |
Gonthier MP et al. | Identification of endocannabinoids and related compounds in human fat cells. | 2007 | Obesity (Silver Spring) | pmid:17426318 |
Starowicz KM et al. | Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet. | 2008 | Obesity (Silver Spring) | pmid:18239598 |
Zelber-Sagi S et al. | Serum levels of endocannabinoids are independently associated with nonalcoholic fatty liver disease. | 2017 | Obesity (Silver Spring) | pmid:27863097 |
Abdulnour J et al. | Circulating endocannabinoids in insulin sensitive vs. insulin resistant obese postmenopausal women. A MONET group study. | 2014 | Obesity (Silver Spring) | pmid:23616305 |
Engeli S et al. | Peripheral endocannabinoid system activity in patients treated with sibutramine. | 2008 | Obesity (Silver Spring) | pmid:18356837 |
Motaghedi R and McGraw TE | The CB1 endocannabinoid system modulates adipocyte insulin sensitivity. | 2008 | Obesity (Silver Spring) | pmid:18551116 |
Tsuyama S et al. | Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. | 2009 | Nutr Neurosci | pmid:19622239 |
Carr RL et al. | Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development. | 2017 | Neurotoxicology | pmid:26642910 |