2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Llorente R et al. | Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system. | 2008 | Dev Neurobiol | pmid:18666205 |
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Solinas M et al. | The endocannabinoid system in brain reward processes. | 2008 | Br. J. Pharmacol. | pmid:18414385 |
Richardson D et al. | Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. | 2008 | Arthritis Res. Ther. | pmid:18416822 |
Ruby MA et al. | Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18794527 |
Ortar G et al. | Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. | 2008 | J. Med. Chem. | pmid:18831576 |
Hoover HS et al. | Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18657971 |
Marinelli S et al. | The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons. | 2008 | J. Neurosci. | pmid:19074027 |
Lu TS et al. | Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. | 2008 | J. Immunol. | pmid:18941231 |
Di Marzo V | Endocannabinoids: synthesis and degradation. | 2008 | Rev. Physiol. Biochem. Pharmacol. | pmid:18481028 |
Awumey EM et al. | Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18375719 |
Hill MN et al. | Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. | 2008 | J Neural Transm | pmid:18974922 |
Ellgren M et al. | Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. | 2008 | Eur Neuropsychopharmacol | pmid:18674887 |
Placzek EA et al. | Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. | 2008 | J. Neurochem. | pmid:18778304 |
Placzek EA et al. | Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. | 2008 | Neuropharmacology | pmid:18760289 |
Qin N et al. | TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. | 2008 | J. Neurosci. | pmid:18550765 |
Lehtonen M et al. | Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes. | 2008 | Chem. Biodivers. | pmid:19035572 |
Njie YF et al. | Aqueous humor outflow effects of 2-arachidonylglycerol. | 2008 | Exp. Eye Res. | pmid:18597752 |
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Motaghedi R and McGraw TE | The CB1 endocannabinoid system modulates adipocyte insulin sensitivity. | 2008 | Obesity (Silver Spring) | pmid:18551116 |
Thiemann G et al. | The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization. | 2008 | Behav. Brain Res. | pmid:17988751 |
Burston JJ et al. | N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18682568 |
Avraham Y et al. | 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the evolution of experimental cholestatic liver disease. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18771906 |
Nyilas R et al. | Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia. | 2009 | Eur. J. Neurosci. | pmid:19453631 |
Garcia-Ovejero D et al. | The endocannabinoid system is modulated in response to spinal cord injury in rats. | 2009 | Neurobiol. Dis. | pmid:18930143 |
Wakley AA and Rasmussen EB | Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats. | 2009 | Pharmacol. Biochem. Behav. | pmid:19602424 |
Prusakiewicz JJ et al. | Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid. | 2009 | Biochemistry | pmid:19603831 |
Long JZ et al. | Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19918051 |
Catani MV et al. | Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. | 2009 | J. Mol. Med. | pmid:18820887 |