2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Battista N et al. | The role of endocannabinoids in gonadal function and fertility along the evolutionary axis. | 2012 | Mol. Cell. Endocrinol. | pmid:22305972 |
Wang PF et al. | Cannabinoid-2 receptor activation protects against infarct and ischemia-reperfusion heart injury. | 2012 | J. Cardiovasc. Pharmacol. | pmid:22113346 |
Fanelli F et al. | Estimation of reference intervals of five endocannabinoids and endocannabinoid related compounds in human plasma by two dimensional-LC/MS/MS. | 2012 | J. Lipid Res. | pmid:22172516 |
Roberts CJ et al. | Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol. | 2012 | Neuroscience | pmid:22192839 |
Giordano C et al. | TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception. | 2012 | Cereb. Cortex | pmid:22139792 |
Higuchi S et al. | Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. | 2012 | PLoS ONE | pmid:22737214 |
Alhouayek M and Muccioli GG | The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. | 2012 | Trends Mol Med | pmid:22917662 |
Li C et al. | Expression and function of monoacylglycerol lipase in mouse β-cells and human islets of Langerhans. | 2012 | Cell. Physiol. Biochem. | pmid:22739267 |
Matuszak N et al. | Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth. | 2012 | Eur J Pharm Sci | pmid:22127371 |
Carloni S et al. | Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. | 2012 | Pediatr. Res. | pmid:22821058 |
Nithipatikom K et al. | Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells. | 2012 | Endocrinology | pmid:22087025 |
Gregg LC et al. | Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. | 2012 | J. Neurosci. | pmid:22787031 |
Deshmukh RR and Sharma PL | Stimulation of accumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats. | 2012 | Pharmacol. Res. | pmid:22728691 |
Clemente JC et al. | Screening and characterization of human monoglyceride lipase active site inhibitors using orthogonal binding and functional assays. | 2012 | J Biomol Screen | pmid:22496098 |
Czifra G et al. | Endocannabinoids regulate growth and survival of human eccrine sweat gland-derived epithelial cells. | 2012 | J. Invest. Dermatol. | pmid:22513781 |
Caprioli A et al. | The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22514334 |
Dubreucq S et al. | Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. | 2012 | Neuropsychopharmacology | pmid:22434220 |
Pucci M et al. | Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. | 2012 | J. Biol. Chem. | pmid:22431736 |
McLaughlin RJ et al. | Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. | 2012 | Eur Neuropsychopharmacol | pmid:22325231 |
Kallendrusch S et al. | Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage. | 2012 | PLoS ONE | pmid:23284665 |
Jones BR et al. | Surrogate matrix and surrogate analyte approaches for definitive quantitation of endogenous biomolecules. | 2012 | Bioanalysis | pmid:23088461 |
Hauer D et al. | Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression. | 2012 | Rev Neurosci | pmid:23006898 |
Gyombolai P et al. | Regulation of endocannabinoid release by G proteins: a paracrine mechanism of G protein-coupled receptor action. | 2012 | Mol. Cell. Endocrinol. | pmid:22075205 |
Song J et al. | Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network. | 2012 | J. Neurosci. | pmid:22496555 |
Psychoyos D et al. | Cannabinoid receptor 1 signaling in embryo neurodevelopment. | 2012 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:22311661 |
Katona I and Freund TF | Multiple functions of endocannabinoid signaling in the brain. | 2012 | Annu. Rev. Neurosci. | pmid:22524785 |
Ueda N et al. | Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol. | 2011 Jan-Feb | Biofactors | pmid:21328621 |
Frazier CJ | Key questions of endocannabinoid signalling in the CNS: which, where and when? | 2011 | J. Physiol. (Lond.) | pmid:22001725 |
Sumislawski JJ et al. | Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. | 2011 | Neuropsychopharmacology | pmid:21849983 |
Zhong P et al. | Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. | 2011 | J. Physiol. (Lond.) | pmid:21911610 |
Marazzi J et al. | Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. | 2011 | J. Immunol. Methods | pmid:21920367 |
Signorello MG et al. | Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway. | 2011 | J. Cell. Biochem. | pmid:21608016 |
Du H et al. | Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. | 2011 | Br. J. Pharmacol. | pmid:21501147 |
Hofmann ME et al. | Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. | 2011 | J. Physiol. (Lond.) | pmid:21646412 |
Sarmad S et al. | Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. | 2011 | J. Neurochem. | pmid:21375532 |
Lourbopoulos A et al. | Administration of 2-arachidonoylglycerol ameliorates both acute and chronic experimental autoimmune encephalomyelitis. | 2011 | Brain Res. | pmid:21406188 |
Kortleven C et al. | The endocannabinoid 2-arachidonoylglycerol inhibits long-term potentiation of glutamatergic synapses onto ventral tegmental area dopamine neurons in mice. | 2011 | Eur. J. Neurosci. | pmid:21410793 |
Oudin MJ et al. | Endocannabinoids regulate the migration of subventricular zone-derived neuroblasts in the postnatal brain. | 2011 | J. Neurosci. | pmid:21411643 |
Hashimotodani Y et al. | Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol. | 2011 | J. Neurosci. | pmid:21414931 |
Howlett AC et al. | Endocannabinoid tone versus constitutive activity of cannabinoid receptors. | 2011 | Br. J. Pharmacol. | pmid:21545414 |
Taschler U et al. | Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. | 2011 | J. Biol. Chem. | pmid:21454566 |
Mulder J et al. | Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. | 2011 | Brain | pmid:21459826 |
Vecchio AJ and Malkowski MG | The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. | 2011 | J. Biol. Chem. | pmid:21489986 |
Balenga NA et al. | GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. | 2011 | Cell Res. | pmid:21467997 |
Shekhar C | Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. | 2011 | Chem. Biol. | pmid:21609833 |
Ho YC et al. | Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition. | 2011 | J. Neurosci. | pmid:21994376 |
Cippitelli A et al. | Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. | 2011 | PLoS ONE | pmid:22140525 |
Brizzi A et al. | Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor. | 2011 | J. Med. Chem. | pmid:22044209 |
Yoshino H et al. | Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. | 2011 | J. Physiol. (Lond.) | pmid:21807615 |
Khasabova IA et al. | Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. | 2011 | Pharmacol. Res. | pmid:21440630 |