2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Petrenko AB et al. | Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. | 2014 | Behav. Brain Res. | pmid:24906199 |
Tiburu EK and Shen L | Distance measurements and conformational analysis of sn-2-arachidonoylglycerol-membrane sample by ²H-³¹P REDOR NMR. | 2014 | J. Membr. Biol. | pmid:24402242 |
Costa MA et al. | 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. | 2014 | Reproduction | pmid:24324206 |
Pava MJ et al. | Endocannabinoid modulation of cortical up-states and NREM sleep. | 2014 | PLoS ONE | pmid:24520411 |
Pascual AC et al. | Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. | 2013 Mar-Apr | Biofactors | pmid:23281018 |
Fonseca BM et al. | Endogenous cannabinoids revisited: a biochemistry perspective. | 2013 Apr-May | Prostaglandins Other Lipid Mediat. | pmid:23474290 |
Valdeolivas S et al. | The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. | 2013 | Cell Death Dis | pmid:24136226 |
Keimpema E et al. | Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23319656 |
Shimizu T et al. | Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats. | 2013 | J. Pharmacol. Sci. | pmid:23386378 |
Alhouayek M et al. | Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24101490 |
Citraro R et al. | Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy. | 2013 | Neuropharmacology | pmid:23206503 |
Lindgren CA et al. | Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction. | 2013 | J. Physiol. (Lond.) | pmid:23818695 |
Frazier CJ | Preformed vs. on-demand: molecular economics of endocannabinoid signalling. | 2013 | J. Physiol. (Lond.) | pmid:24085490 |
Descalzi F et al. | Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. | 2013 | Tissue Eng Part A | pmid:23578218 |
Bisogno T et al. | A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. | 2013 | Br. J. Pharmacol. | pmid:23072382 |
Hill MN et al. | Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. | 2013 | Psychoneuroendocrinology | pmid:24035186 |
Bernabò N et al. | Systems biology analysis of the endocannabinoid system reveals a scale-free network with distinct roles for anandamide and 2-arachidonoylglycerol. | 2013 | OMICS | pmid:24117401 |
Shinjyo N et al. | Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. | 2013 | J. Neurosci. Res. | pmid:23633391 |
Malenczyk K et al. | CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. | 2013 | J. Biol. Chem. | pmid:24089517 |
Brocato B et al. | Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. | 2013 | Placenta | pmid:24008071 |