2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fezza F et al. | Endocannabinoids, related compounds and their metabolic routes. | 2014 | Molecules | pmid:25347455 |
Flores-Otero J et al. | Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. | 2014 | Nat Commun | pmid:25081814 |
Bluett RJ et al. | Endocannabinoid signalling modulates susceptibility to traumatic stress exposure. | 2017 | Nat Commun | pmid:28348378 |
Tung LW et al. | Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. | 2016 | Nat Commun | pmid:27448020 |
Jung KM et al. | Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. | 2012 | Nat Commun | pmid:23011134 |
Alpár A et al. | Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. | 2014 | Nat Commun | pmid:25030704 |
Iannotti FA et al. | Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy. | 2018 | Nat Commun | pmid:30262909 |
Duggan KC et al. | (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. | 2011 | Nat. Chem. Biol. | pmid:22053353 |
Hsu KL et al. | DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. | 2012 | Nat. Chem. Biol. | pmid:23103940 |
Nomura DK et al. | Activation of the endocannabinoid system by organophosphorus nerve agents. | 2008 | Nat. Chem. Biol. | pmid:18438404 |
Long JZ et al. | Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. | 2009 | Nat. Chem. Biol. | pmid:19029917 |
Kim J and Alger BE | Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. | 2004 | Nat. Neurosci. | pmid:15184902 |
Lourenço J et al. | Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. | 2010 | Nat. Neurosci. | pmid:20081851 |
Puente N et al. | Polymodal activation of the endocannabinoid system in the extended amygdala. | 2011 | Nat. Neurosci. | pmid:22057189 |
Self DW | Anandamide: a candidate neurotransmitter heads for the big leagues. | 1999 | Nat. Neurosci. | pmid:10204533 |
Shonesy BC et al. | CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling. | 2013 | Nat. Neurosci. | pmid:23502535 |
Kim J and Alger BE | Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. | 2010 | Nat. Neurosci. | pmid:20348918 |
Maccarrone M et al. | Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. | 2008 | Nat. Neurosci. | pmid:18204441 |
Di Marzo V | Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. | 2011 | Nat. Neurosci. | pmid:21187849 |
Makara JK et al. | Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. | 2005 | Nat. Neurosci. | pmid:16116451 |