2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Hyperkinesis D006948 11 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Encephalitis D004660 15 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Hypothermia D007035 19 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Brain Edema D001929 20 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

Download all related citations
Per page 10 20 50 100 | Total 1060
Authors Title Published Journal PubMed Link
Zou Z et al. Endocannabinoid 2-Arachidonoylglycerol Suppresses LPS-Induced Inhibition of A-Type Potassium Channel Currents in Caudate Nucleus Neurons Through CB1 Receptor. 2016 J. Mol. Neurosci. pmid:27129498
Limebeer CL et al. Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model. 2016 Behav. Neurosci. pmid:26974857
Wang X et al. Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. 2016 Biomed Res Int pmid:26904688
González-Mariscal I et al. Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. 2016 Mol. Cell. Endocrinol. pmid:26724516
Gobira PH et al. Role of the endocannabinoid 2-arachidonoylglycerol in aversive responses mediated by the dorsolateral periaqueductal grey. 2016 Eur Neuropsychopharmacol pmid:26628106
Lu HC and Mackie K An Introduction to the Endogenous Cannabinoid System. 2016 Biol. Psychiatry pmid:26698193
Signorello MG and Leoncini G Regulation of cAMP Intracellular Levels in Human Platelets Stimulated by 2-Arachidonoylglycerol. 2016 J. Cell. Biochem. pmid:26460717
Wang F et al. 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation. 2016 Rejuvenation Res pmid:26414218
Knani I et al. Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome. 2016 Mol Metab pmid:27900261
Liu X et al. Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase. 2016 Sci Rep pmid:27775008
Tung LW et al. Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. 2016 Nat Commun pmid:27448020
Kudalkar SN et al. Assay of Endocannabinoid Oxidation by Cyclooxygenase-2. 2016 Methods Mol. Biol. pmid:27245906
Jung KM and Piomelli D Assay of Monoacylglycerol Lipase Activity. 2016 Methods Mol. Biol. pmid:27245902
Reddy IA et al. Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. 2016 Transl Psychiatry pmid:27187231
Gray JM et al. Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. 2016 Psychoneuroendocrinology pmid:26821211
Dong L et al. Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2. 2016 J. Lipid Res. pmid:27059979
Morena M et al. Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. 2016 Neuropharmacology pmid:27553121
Veeraraghavan P et al. A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro. 2016 Neuroscience pmid:27450568
van Zadelhoff G and van der Stelt M Oxygenation of Anandamide by Lipoxygenases. 2016 Methods Mol. Biol. pmid:27245907
Martella A et al. Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop. 2016 Endocrinology pmid:27014939
Yang W et al. Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells. 2016 Neuroscience pmid:26621126
Sustkova-Fiserova M et al. Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens. 2016 Psychopharmacology (Berl.) pmid:26507196
Leishman E et al. Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. 2016 Pharmacol. Res. pmid:27109320
Rajaraman G et al. G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction. 2016 Mol Nutr Food Res pmid:26337420
Leishman E et al. Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain. 2016 Biochim. Biophys. Acta pmid:26956082
Petrosino S et al. The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels. 2016 Br. J. Pharmacol. pmid:25598150
Sido JM et al. Production of endocannabinoids by activated T cells and B cells modulates inflammation associated with delayed-type hypersensitivity. 2016 Eur. J. Immunol. pmid:27064137
Brose SA et al. Brain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia-Injury Which Is Prevented by Microwave Irradiation. 2016 Lipids pmid:27021494
Delgado-Peraza F et al. Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor. 2016 Mol. Pharmacol. pmid:27009233
Miller MR et al. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. 2016 Science pmid:26989199
Yan W et al. NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication. 2016 Sci Rep pmid:26928013
Hartley ND et al. 2-arachidonoylglycerol signaling impairs short-term fear extinction. 2016 Transl Psychiatry pmid:26926885
Brindisi M et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. 2016 J. Med. Chem. pmid:26888301
Tegeder I Endocannabinoids as Guardians of Metastasis. 2016 Int J Mol Sci pmid:26875980
Pastor A et al. A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women. 2016 PLoS ONE pmid:26849214
Wilkerson JL et al. The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. 2016 J. Pharmacol. Exp. Ther. pmid:26791602
Aso C et al. Protein purification and cloning of diacylglycerol lipase from rat brain. 2016 J. Biochem. pmid:26790472
Buczynski MW et al. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:26755579
Lim J et al. Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. 2016 Neuropsychopharmacology pmid:26361059
Volk DW and Lewis DA The Role of Endocannabinoid Signaling in Cortical Inhibitory Neuron Dysfunction in Schizophrenia. 2016 Biol. Psychiatry pmid:26210060
Fisette A et al. α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. 2016 Cell Rep pmid:27783937
Sugaya Y et al. Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures. 2016 Cell Rep pmid:27452464
Bosch-Bouju C et al. Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress. 2016 Cell Rep pmid:27452462
Cristino L et al. Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency. 2016 Neuropsychopharmacology pmid:26081302
Imperatore R et al. Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation. 2016 Pharmacol. Res. pmid:27436148
Janssen FJ and van der Stelt M Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. 2016 Bioorg. Med. Chem. Lett. pmid:27394666
Mwanza C et al. Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. 2016 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:27318292
Bisogno T Assay of DAGLα/β Activity. 2016 Methods Mol. Biol. pmid:27245901
Battista N and Sergi M Determination of 2-Arachidonoylglycerol by μSPE-LC-MS/MS. 2016 Methods Mol. Biol. pmid:27245888
Liisberg U et al. Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice. 2016 J. Nutr. Biochem. pmid:27155918