| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Fatty Liver, Alcoholic | D005235 | 11 associated lipids |
| Fragile X Syndrome | D005600 | 5 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hepatic Encephalopathy | D006501 | 9 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
| Hyperkinesis | D006948 | 11 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lambert DM and Fowler CJ | The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. | 2005 | J. Med. Chem. | pmid:16078824 |
| Hayase T et al. | Persistent anxiogenic effects of a single or repeated doses of cocaine and methamphetamine: interactions with endogenous cannabinoid receptor ligands. | 2005 | Behav Pharmacol | pmid:16148444 |
| Gokoh M et al. | 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells. | 2005 | Biochem. J. | pmid:15456404 |
| Hohmann AG et al. | An endocannabinoid mechanism for stress-induced analgesia. | 2005 | Nature | pmid:15973410 |
| Sancho R et al. | Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine. | 2005 | J. Immunol. | pmid:16148147 |
| Harada N et al. | Effects of cannabinoids on colonic muscle contractility and tension in guinea pigs. | 2005 | J Nippon Med Sch | pmid:15834207 |
| Oka S et al. | Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear. | 2005 | J. Biol. Chem. | pmid:15749716 |
| Kishimoto S et al. | Endogenous cannabinoid receptor ligand induces the migration of human natural killer cells. | 2005 | J. Biochem. | pmid:15749836 |
| Kaplan BL et al. | 2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2. | 2005 | J. Leukoc. Biol. | pmid:15774549 |
| Lauckner JE et al. | The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16365309 |
| Hill MN et al. | Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala. | 2005 | Eur. J. Pharmacol. | pmid:16324692 |
| Gokoh M et al. | 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, enhances the adhesion of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes. | 2005 | FEBS Lett. | pmid:16288744 |
| Straiker A and Mackie K | Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. | 2005 | J. Physiol. (Lond.) | pmid:16179366 |
| Iturralde M et al. | Characterization of the lipolytic pathways that mediate free fatty acid release during Fas/CD95-induced apoptosis. | 2005 | Apoptosis | pmid:16215685 |
| Engeli S et al. | Activation of the peripheral endocannabinoid system in human obesity. | 2005 | Diabetes | pmid:16186383 |
| Safo PK and Regehr WG | Endocannabinoids control the induction of cerebellar LTD. | 2005 | Neuron | pmid:16301180 |
| Alger BE | Endocannabinoid identification in the brain: studies of breakdown lead to breakthrough, and there may be NO hope. | 2005 | Sci. STKE | pmid:16278487 |
| Maccarrone M et al. | Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. | 2005 | Mol. Hum. Reprod. | pmid:15563449 |
| Rademacher DJ et al. | Waterborne lead exposure affects brain endocannabinoid content in male but not female fathead minnows (Pimephales promelas). | 2005 | Neurotoxicology | pmid:15527869 |
| Shoemaker JL et al. | Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors. | 2005 | J. Pharmacol. Exp. Ther. | pmid:16081674 |
| Ligresti A et al. | Endocannabinoid metabolic pathways and enzymes. | 2005 | Curr Drug Targets CNS Neurol Disord | pmid:16375679 |
| Gopez JJ et al. | Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury. | 2005 | Neurosurgery | pmid:15730585 |
| Zhao Q et al. | 2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells. | 2005 | J. Biol. Chem. | pmid:15886210 |
| Rouzer CA and Marnett LJ | Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus. | 2005 | J. Biol. Chem. | pmid:15917246 |
| Nithipatikom K et al. | A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15919052 |
| Darmani NA et al. | Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew. | 2005 | Neuropharmacology | pmid:15921709 |
| Kola B et al. | Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. | 2005 | J. Biol. Chem. | pmid:15899896 |
| Shoemaker JL et al. | The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15901805 |
| Saario SM et al. | Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. | 2005 | Chem. Biol. | pmid:15975510 |
| Di S et al. | Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. | 2005 | J. Physiol. (Lond.) | pmid:16239276 |
| Cabranes A et al. | Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis. | 2005 | Neurobiol. Dis. | pmid:16242629 |
| Wagner JA et al. | Coronary vasodilator effects of endogenous cannabinoids in vasopressin-preconstricted unpaced rat isolated hearts. | 2005 | J. Cardiovasc. Pharmacol. | pmid:16116341 |
| McPartland JM et al. | Cannabimimetic effects of osteopathic manipulative treatment. | 2005 | J Am Osteopath Assoc | pmid:16118355 |
| Wahn H et al. | The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16055511 |
| Kurabayashi M et al. | 2-Arachidonoylglycerol increases in ischemia-reperfusion injury of the rat liver. | 2005 Jan-Feb | J Invest Surg | pmid:15804949 |
| Matias I et al. | Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17011761 |
| Spoto B et al. | Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. | 2006 | Biochimie | pmid:16949718 |
| Wagner JA et al. | 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts. | 2006 | J. Cardiovasc. Pharmacol. | pmid:16775503 |
| Quistad GB et al. | Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16310817 |
| Panikashvili D et al. | The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. | 2006 | Neurobiol. Dis. | pmid:16364651 |
| Avraham Y et al. | Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice. | 2006 | Neurobiol. Dis. | pmid:16102970 |
| Saario SM et al. | URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain. | 2006 | Chem. Biol. | pmid:16931330 |
| Sang N et al. | PGE2 glycerol ester, a COX-2 oxidative metabolite of 2-arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neurons. | 2006 | J. Physiol. (Lond.) | pmid:16484297 |
| Parkkari T et al. | Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16466915 |
| Kurihara R et al. | Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils. | 2006 | J. Biol. Chem. | pmid:16513651 |
| Mestre L et al. | The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection. | 2006 | Biochem. Pharmacol. | pmid:16914119 |
| Blüher M et al. | Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. | 2006 | Diabetes | pmid:17065342 |
| Shiga N et al. | Elimination of 2-arachidonoylglycerol action by direct hemoperfusion through immobilized polymyxin B fibers: an experimental study in conscious guinea pigs. | 2006 | Ther Apher Dial | pmid:17199882 |
| McCarron RM et al. | Endothelial-mediated regulation of cerebral microcirculation. | 2006 | J. Physiol. Pharmacol. | pmid:17244945 |
| Parrish JC and Nichols DE | Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism. | 2006 | J. Neurochem. | pmid:17010161 |