| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Fatty Liver, Alcoholic | D005235 | 11 associated lipids |
| Fragile X Syndrome | D005600 | 5 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hepatic Encephalopathy | D006501 | 9 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
| Hyperkinesis | D006948 | 11 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Costa MA et al. | 2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental development. | 2015 | Mol. Cell. Endocrinol. | pmid:25199616 |
| Viader A et al. | Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. | 2015 | Cell Rep | pmid:26212325 |
| Thieme U et al. | Quantification of anandamide and 2-arachidonoylglycerol plasma levels to examine potential influences of tetrahydrocannabinol application on the endocannabinoid system in humans. | 2014 Jan-Feb | Drug Test Anal | pmid:24424856 |
| den Boon FS et al. | Endocannabinoids produced upon action potential firing evoke a Cl(-) current via type-2 cannabinoid receptors in the medial prefrontal cortex. | 2014 | Pflugers Arch. | pmid:24671573 |
| Shonesy BC et al. | Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. | 2014 | Cell Rep | pmid:25466252 |
| Gasperi V et al. | 2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts. | 2014 | Cell Cycle | pmid:25427281 |
| Zhang J et al. | Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease. | 2014 | J. Neurosci. | pmid:25378159 |
| Fezza F et al. | Endocannabinoids, related compounds and their metabolic routes. | 2014 | Molecules | pmid:25347455 |
| Flores-Otero J et al. | Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. | 2014 | Nat Commun | pmid:25081814 |
| Pastor A et al. | Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. | 2014 | J. Lipid Res. | pmid:24610889 |
| Stanley CP and O'Sullivan SE | Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries. | 2014 | Pharmacol. Res. | pmid:24548820 |
| Signorello MG and Leoncini G | Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway. | 2014 | Biochimie | pmid:25068972 |
| Fernández-Suárez D et al. | Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. | 2014 | Neurobiol. Aging | pmid:24973119 |
| Petrenko AB et al. | Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. | 2014 | Behav. Brain Res. | pmid:24906199 |
| Tsurumura T and Tsuge H | Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure. | 2014 | J. Struct. Funct. Genomics | pmid:24894647 |
| Pascual AC et al. | Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging. | 2014 | Exp. Gerontol. | pmid:24768821 |
| Gasperi V et al. | 2-Arachidonoylglycerol modulates human endothelial cell/leukocyte interactions by controlling selectin expression through CB1 and CB2 receptors. | 2014 | Int. J. Biochem. Cell Biol. | pmid:24721209 |
| Lu Y et al. | Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against LPS-induced impairments in rat caudate nucleus. | 2014 | J. Mol. Neurosci. | pmid:24510751 |
| Alhouayek M et al. | Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy. | 2014 | Drug Discov. Today | pmid:23891880 |
| Khasabova IA et al. | JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. | 2014 | Pharmacol. Res. | pmid:25304184 |
| McDougle DR et al. | Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. | 2014 | J. Pharmacol. Exp. Ther. | pmid:25277139 |
| Özdemir B et al. | Endocannabinoids and inflammatory response in periodontal ligament cells. | 2014 | PLoS ONE | pmid:25226300 |
| Lau BK et al. | Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. | 2014 | Br. J. Pharmacol. | pmid:25041240 |
| Laprairie RB et al. | Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. | 2014 | J. Biol. Chem. | pmid:25037227 |
| Navarria A et al. | The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. | 2014 | Pharmacol. Res. | pmid:24861565 |
| Oleson EB et al. | Cannabinoid receptor activation shifts temporally engendered patterns of dopamine release. | 2014 | Neuropsychopharmacology | pmid:24345819 |
| Larose MC et al. | Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol. | 2014 | J. Allergy Clin. Immunol. | pmid:24530098 |
| Abdulnour J et al. | Circulating endocannabinoids in insulin sensitive vs. insulin resistant obese postmenopausal women. A MONET group study. | 2014 | Obesity (Silver Spring) | pmid:23616305 |
| Brantl SA et al. | Activation of platelets by the endocannabinoids 2-arachidonoylglycerol and virodhamine is mediated by their conversion to arachidonic acid and thromboxane A2, not by activation of cannabinoid receptors. | 2014 | Platelets | pmid:24102401 |
| Brantl SA et al. | Mechanism of platelet activation induced by endocannabinoids in blood and plasma. | 2014 | Platelets | pmid:23789792 |
| Iannotti FA et al. | The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24927567 |
| Tiburu EK and Shen L | Distance measurements and conformational analysis of sn-2-arachidonoylglycerol-membrane sample by ²H-³¹P REDOR NMR. | 2014 | J. Membr. Biol. | pmid:24402242 |
| Costa MA et al. | 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. | 2014 | Reproduction | pmid:24324206 |
| Laitinen T et al. | Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. | 2014 | Mol. Pharmacol. | pmid:24368842 |
| Koltyn KF et al. | Mechanisms of exercise-induced hypoalgesia. | 2014 | J Pain | pmid:25261342 |
| Melis M et al. | Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. | 2014 | J. Neurosci. | pmid:25232109 |
| Murataeva N et al. | Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS. | 2014 | Br. J. Pharmacol. | pmid:24102242 |
| Alvheim AR et al. | Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet. | 2014 | Lipids | pmid:24081493 |
| Yang K et al. | Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. | 2014 | Hippocampus | pmid:25087967 |
| Fezza F et al. | Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. | 2014 | Mol. Cell. Neurosci. | pmid:25064144 |
| Jergas B et al. | O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus. | 2014 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:24853577 |
| Pava MJ et al. | Endocannabinoid modulation of cortical up-states and NREM sleep. | 2014 | PLoS ONE | pmid:24520411 |
| Sanson B et al. | Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. | 2014 | Acta Crystallogr. D Biol. Crystallogr. | pmid:24531463 |
| Ohno-Shosaku T and Kano M | Endocannabinoid-mediated retrograde modulation of synaptic transmission. | 2014 | Curr. Opin. Neurobiol. | pmid:24747340 |
| Chianese R et al. | Hypothalamus-pituitary axis: an obligatory target for endocannabinoids to inhibit steroidogenesis in frog testis. | 2014 | Gen. Comp. Endocrinol. | pmid:24566122 |
| Rea K et al. | Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state. | 2014 | Eur. J. Neurosci. | pmid:24494683 |
| Zheng Y et al. | Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system. | 2014 | Eur. J. Pharmacol. | pmid:24508383 |
| Limebeer CL et al. | Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system. | 2014 | Psychopharmacology (Berl.) | pmid:24043345 |
| Kim J and Watkins BA | Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity. | 2014 | J. Nutr. Biochem. | pmid:24854955 |
| Manna JD et al. | Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. | 2014 | J. Biol. Chem. | pmid:25301951 |