| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Obesity | D009765 | 29 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Starvation | D013217 | 47 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Martins CJ et al. | Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. | 2015 | PLoS ONE | pmid:26561012 |
| Katz PS et al. | Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury. | 2015 | J. Neurotrauma | pmid:25166905 |
| Zhang Z et al. | Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity. | 2015 | Hippocampus | pmid:25131612 |
| Altamura C et al. | Elevation of Plasma 2-Arachidonoylglycerol Levels in Alzheimer's Disease Patients as a Potential Protective Mechanism against Neurodegenerative Decline. | 2015 | J. Alzheimers Dis. | pmid:25818503 |
| Lecru L et al. | Cannabinoid receptor 1 is a major mediator of renal fibrosis. | 2015 | Kidney Int. | pmid:25760323 |
| Mann A et al. | Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury. | 2015 | J Neuroimmune Pharmacol | pmid:25721934 |
| Szekeres M et al. | Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension. | 2015 | Mol. Cell. Endocrinol. | pmid:25595485 |
| Turcotte C et al. | Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites. | 2015 | J. Leukoc. Biol. | pmid:25877930 |
| Spaziano G et al. | Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. | 2015 | Biomed Res Int | pmid:25866824 |
| Subbanna S et al. | Postnatal ethanol exposure alters levels of 2-arachidonylglycerol-metabolizing enzymes and pharmacological inhibition of monoacylglycerol lipase does not cause neurodegeneration in neonatal mice. | 2015 | J. Neurochem. | pmid:25857698 |
| Nicholson J et al. | Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. | 2015 | PLoS ONE | pmid:25835291 |
| Llorente-Berzal A et al. | 2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons. | 2015 | Psychopharmacology (Berl.) | pmid:25814137 |
| Pisanti S et al. | Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. | 2015 | J. Cell. Physiol. | pmid:25684344 |
| Aliczki M et al. | Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. | 2015 | Psychopharmacology (Berl.) | pmid:25547462 |
| Checa A et al. | Lipid mediator profile in vernix caseosa reflects skin barrier development. | 2015 | Sci Rep | pmid:26521946 |
| Jalin AM et al. | Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity. | 2015 | PLoS ONE | pmid:26517721 |
| Morena M et al. | Training-Associated Emotional Arousal Shapes Endocannabinoid Modulation of Spatial Memory Retrieval in Rats. | 2015 | J. Neurosci. | pmid:26468197 |
| Dotsey EY et al. | Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. | 2015 | Chem. Biol. | pmid:26000748 |
| Chicca A et al. | 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. | 2015 | J Neuroinflammation | pmid:25962384 |
| Liu Z et al. | Involvement of GluR2 up-regulation in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptor in mice. | 2015 | Sci Rep | pmid:25830356 |