| MeSH term | MeSH ID | Detail |
|---|---|---|
| Memory Disorders | D008569 | 33 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Obesity | D009765 | 29 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Myocardial Reperfusion Injury | D015428 | 20 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Liver Cirrhosis, Alcoholic | D008104 | 17 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Hyperkinesis | D006948 | 11 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shonesy BC et al. | Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. | 2014 | Cell Rep | pmid:25466252 |
| Gasperi V et al. | 2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts. | 2014 | Cell Cycle | pmid:25427281 |
| Smaga I et al. | Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures. | 2014 | Neurotox Res | pmid:24652522 |
| Kohnz RA and Nomura DK | Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids. | 2014 | Chem Soc Rev | pmid:24676249 |
| Pastor A et al. | Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. | 2014 | J. Lipid Res. | pmid:24610889 |
| Stanley CP and O'Sullivan SE | Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries. | 2014 | Pharmacol. Res. | pmid:24548820 |
| Pérez-Morales M et al. | 2-Arachidonoylglycerol into the lateral hypothalamus improves reduced sleep in adult rats subjected to maternal separation. | 2014 | Neuroreport | pmid:25356522 |
| Signorello MG and Leoncini G | Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway. | 2014 | Biochimie | pmid:25068972 |
| Morena M et al. | Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25489086 |
| Wiley JL et al. | Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents. | 2014 | Eur. J. Pharmacol. | pmid:24858366 |
| Nader J et al. | Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. | 2014 | Neuropharmacology | pmid:24709540 |
| Sun LJ et al. | Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication. | 2014 | Int. J. Infect. Dis. | pmid:24704332 |
| Basavarajappa BS et al. | Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice. | 2014 | Hippocampus | pmid:24648181 |
| Aaltonen N et al. | Brain regional cannabinoid CB(1) receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice. | 2014 | Eur J Pharm Sci | pmid:24012970 |
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| Iannotti FA et al. | The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24927567 |
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| Burston JJ and Woodhams SG | Endocannabinoid system and pain: an introduction. | 2014 | Proc Nutr Soc | pmid:24148358 |
| Desroches J et al. | Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CBâ‚ and CBâ‚‚ receptors. | 2014 | Neuropharmacology | pmid:24148808 |
| Yang K et al. | Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. | 2014 | Hippocampus | pmid:25087967 |
| Fezza F et al. | Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. | 2014 | Mol. Cell. Neurosci. | pmid:25064144 |
| Sanson B et al. | Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. | 2014 | Acta Crystallogr. D Biol. Crystallogr. | pmid:24531463 |
| Schaefer C et al. | Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders. | 2014 | Eur Arch Psychiatry Clin Neurosci | pmid:24253425 |
| Limebeer CL et al. | Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system. | 2014 | Psychopharmacology (Berl.) | pmid:24043345 |
| Pascual AC et al. | Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. | 2013 Mar-Apr | Biofactors | pmid:23281018 |
| Fonseca BM et al. | Endogenous cannabinoids revisited: a biochemistry perspective. | 2013 Apr-May | Prostaglandins Other Lipid Mediat. | pmid:23474290 |
| Fagundo AB et al. | Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. | 2013 | PLoS ONE | pmid:23840456 |
| Chouinard F et al. | 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV. | 2013 | J. Leukoc. Biol. | pmid:23242611 |
| Rivera P et al. | Cocaine self-administration differentially modulates the expression of endogenous cannabinoid system-related proteins in the hippocampus of Lewis vs. Fischer 344 rats. | 2013 | Int. J. Neuropsychopharmacol. | pmid:23217608 |
| Valdeolivas S et al. | The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. | 2013 | Cell Death Dis | pmid:24136226 |
| Jäntti MH et al. | Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling. | 2013 | Mol. Pharmacol. | pmid:23233488 |
| Su LD et al. | Retrograde cPLA2α/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation. | 2013 | Cerebellum | pmid:23307660 |
| Keimpema E et al. | Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23319656 |
| Shimizu T et al. | Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats. | 2013 | J. Pharmacol. Sci. | pmid:23386378 |
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| Alhouayek M et al. | Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24101490 |
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| Lindgren CA et al. | Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction. | 2013 | J. Physiol. (Lond.) | pmid:23818695 |
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| Bisogno T et al. | A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. | 2013 | Br. J. Pharmacol. | pmid:23072382 |
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| Hill MN et al. | Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. | 2013 | Psychoneuroendocrinology | pmid:24035186 |
| Bernabò N et al. | Systems biology analysis of the endocannabinoid system reveals a scale-free network with distinct roles for anandamide and 2-arachidonoylglycerol. | 2013 | OMICS | pmid:24117401 |
| Gesell FK et al. | Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. | 2013 | BMC Vet. Res. | pmid:24370333 |
| Shinjyo N et al. | Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. | 2013 | J. Neurosci. Res. | pmid:23633391 |
| Malenczyk K et al. | CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. | 2013 | J. Biol. Chem. | pmid:24089517 |
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