2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Hypotension D007022 41 associated lipids
Hypothermia D007035 19 associated lipids
Inflammation D007249 119 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Memory Disorders D008569 33 associated lipids
Morphine Dependence D009021 9 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neuralgia D009437 28 associated lipids
Neuromyelitis Optica D009471 2 associated lipids
Obesity D009765 29 associated lipids
Pain D010146 64 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Starvation D013217 47 associated lipids
Stomach Ulcer D013276 75 associated lipids
Reperfusion Injury D015427 65 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Weight Gain D015430 101 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

Download all related citations
Per page 10 20 50 100 | Total 1060
Authors Title Published Journal PubMed Link
Park SW et al. Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species. 2015 Head Neck pmid:24797795
Scotchie JG et al. Endocannabinoid regulation in human endometrium across the menstrual cycle. 2015 Reprod Sci pmid:24819878
Jergas B et al. O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus. 2014 Naunyn Schmiedebergs Arch. Pharmacol. pmid:24853577
Kim J and Watkins BA Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity. 2014 J. Nutr. Biochem. pmid:24854955
Wiley JL et al. Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents. 2014 Eur. J. Pharmacol. pmid:24858366
Navarria A et al. The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. 2014 Pharmacol. Res. pmid:24861565
Hillard CJ Stress regulates endocannabinoid-CB1 receptor signaling. 2014 Semin. Immunol. pmid:24882055
Tsurumura T and Tsuge H Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure. 2014 J. Struct. Funct. Genomics pmid:24894647
Petrenko AB et al. Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. 2014 Behav. Brain Res. pmid:24906199
Iannotti FA et al. The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24927567
Karabowicz P et al. [Role of endocannabinoid 2-arachidonoylglycerol in the physiology and pathophysiology of the cardiovascular system]. 2014 Postepy Hig Med Dosw (Online) pmid:24934539
Pulgar VM et al. Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. 2014 Hypertension pmid:24935942
Nithipatikom K et al. A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol. 2014 J. Lipid Res. pmid:24958911
Fernández-Suárez D et al. Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. 2014 Neurobiol. Aging pmid:24973119
Dong M et al. Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against homocysteine-induced impairments in rat caudate nucleus through CB1 receptor. 2015 J. Mol. Neurosci. pmid:25007951
Cipriano M et al. The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. 2014 BMC Res Notes pmid:25012825
Alpár A et al. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. 2014 Nat Commun pmid:25030704
Laprairie RB et al. Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. 2014 J. Biol. Chem. pmid:25037227
Lau BK et al. Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. 2014 Br. J. Pharmacol. pmid:25041240
Fezza F et al. Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. 2014 Mol. Cell. Neurosci. pmid:25064144
Signorello MG and Leoncini G Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway. 2014 Biochimie pmid:25068972
Flores-Otero J et al. Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. 2014 Nat Commun pmid:25081814
Yang K et al. Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. 2014 Hippocampus pmid:25087967
Zhang Z et al. Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity. 2015 Hippocampus pmid:25131612
Katz PS et al. Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury. 2015 J. Neurotrauma pmid:25166905
Costa MA et al. 2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental development. 2015 Mol. Cell. Endocrinol. pmid:25199616
Özdemir B et al. Endocannabinoids and inflammatory response in periodontal ligament cells. 2014 PLoS ONE pmid:25226300
Melis M et al. Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. 2014 J. Neurosci. pmid:25232109
Koltyn KF et al. Mechanisms of exercise-induced hypoalgesia. 2014 J Pain pmid:25261342
McDougle DR et al. Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. 2014 J. Pharmacol. Exp. Ther. pmid:25277139
Manna JD et al. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. 2014 J. Biol. Chem. pmid:25301951
Khasabova IA et al. JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. 2014 Pharmacol. Res. pmid:25304184
García del Caño G et al. Nuclear diacylglycerol lipase-α in rat brain cortical neurons: evidence of 2-arachidonoylglycerol production in concert with phospholipase C-β activity. 2015 J. Neurochem. pmid:25308538
Fezza F et al. Endocannabinoids, related compounds and their metabolic routes. 2014 Molecules pmid:25347455
Pérez-Morales M et al. 2-Arachidonoylglycerol into the lateral hypothalamus improves reduced sleep in adult rats subjected to maternal separation. 2014 Neuroreport pmid:25356522
Hanlon EC et al. Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol. 2015 J. Clin. Endocrinol. Metab. pmid:25368979
Zhang J et al. Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease. 2014 J. Neurosci. pmid:25378159
Alhouayek M et al. N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis. 2015 FASEB J. pmid:25384424
Gasperi V et al. 2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts. 2014 Cell Cycle pmid:25427281
Pacioni G et al. Truffles contain endocannabinoid metabolic enzymes and anandamide. 2015 Phytochemistry pmid:25433633
Shonesy BC et al. Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. 2014 Cell Rep pmid:25466252
Shonesy BC et al. The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. 2015 Neuropharmacology pmid:25484252
Morena M et al. Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25489086
Zhang J et al. Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. 2015 J. Cereb. Blood Flow Metab. pmid:25492114
Pasquarelli N et al. Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue. 2015 Neuropharmacology pmid:25497453
Sticht MA et al. Intra-visceral insular cortex 2-arachidonoylglycerol, but not N-arachidonoylethanolamide, suppresses acute nausea-induced conditioned gaping in rats. 2015 Neuroscience pmid:25499318
Ford GK et al. Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. 2015 Eur J Pain pmid:25504741
Ivanov I et al. A simple method for simultaneous determination of N-arachidonoylethanolamine, N-oleoylethanolamine, N-palmitoylethanolamine and 2-arachidonoylglycerol in human cells. 2015 Anal Bioanal Chem pmid:25519724
Marcaggi P Cerebellar endocannabinoids: retrograde signaling from purkinje cells. 2015 Cerebellum pmid:25520276
Urquhart P et al. Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases. 2015 Biochim. Biophys. Acta pmid:25543004