2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Epilepsy D004827 35 associated lipids
Nerve Degeneration D009410 53 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Morphine Dependence D009021 9 associated lipids
Catalepsy D002375 30 associated lipids
Hyperkinesis D006948 11 associated lipids
Hyperinsulinism D006946 27 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Hypothermia D007035 19 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Head Injuries, Closed D016489 5 associated lipids
Brain Concussion D001924 5 associated lipids
Encephalitis D004660 15 associated lipids
Memory Disorders D008569 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

Download all related citations
Per page 10 20 50 100 | Total 1060
Authors Title Published Journal PubMed Link
Midtbø LK et al. Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice. 2015 J. Nutr. Biochem. pmid:25776459
Niki M et al. Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice. 2015 J. Physiol. (Lond.) pmid:25728242
Bashashati M et al. Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation. 2015 Br. J. Pharmacol. pmid:25684407
Schaich CL et al. Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. 2015 J. Cardiovasc. Pharmacol. pmid:25636077
Belluomo I et al. Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes. 2015 J. Neurochem. pmid:25626460
Martins CJ et al. Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. 2015 PLoS ONE pmid:26561012
Katz PS et al. Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury. 2015 J. Neurotrauma pmid:25166905
Alizadeh A et al. Role of cannabinoidergic system on food intake in neonatal layer-type chicken. 2015 Vet. Res. Commun. pmid:25902906
Zhang Z et al. Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity. 2015 Hippocampus pmid:25131612
Gomez O et al. A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways. 2015 J Neuroimmune Pharmacol pmid:25900077
Shimizu T et al. Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat. 2015 Neuropharmacology pmid:25882827
Smith M et al. The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. 2015 PLoS ONE pmid:26414859
Gong Y et al. Simultaneous determination of endocannabinoids in murine plasma and brain substructures by surrogate-based LC-MS/MS: Application in tumor-bearing mice. 2015 J Pharm Biomed Anal pmid:25863017
Altamura C et al. Elevation of Plasma 2-Arachidonoylglycerol Levels in Alzheimer's Disease Patients as a Potential Protective Mechanism against Neurodegenerative Decline. 2015 J. Alzheimers Dis. pmid:25818503
Lecru L et al. Cannabinoid receptor 1 is a major mediator of renal fibrosis. 2015 Kidney Int. pmid:25760323
Mann A et al. Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury. 2015 J Neuroimmune Pharmacol pmid:25721934
Marcaggi P Cerebellar endocannabinoids: retrograde signaling from purkinje cells. 2015 Cerebellum pmid:25520276
Szekeres M et al. Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension. 2015 Mol. Cell. Endocrinol. pmid:25595485
Li B et al. Endogenous 2-Arachidonoylglycerol Alleviates Cyclooxygenases-2 Elevation-Mediated Neuronal Injury From SO2 Inhalation via PPARγ Pathway. 2015 Toxicol. Sci. pmid:26209559
Turcotte C et al. Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites. 2015 J. Leukoc. Biol. pmid:25877930
Spaziano G et al. Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. 2015 Biomed Res Int pmid:25866824
Subbanna S et al. Postnatal ethanol exposure alters levels of 2-arachidonylglycerol-metabolizing enzymes and pharmacological inhibition of monoacylglycerol lipase does not cause neurodegeneration in neonatal mice. 2015 J. Neurochem. pmid:25857698
Nicholson J et al. Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. 2015 PLoS ONE pmid:25835291
Patsenker E et al. Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation. 2015 Int J Mol Sci pmid:25826533
Ivanov I et al. A simple method for simultaneous determination of N-arachidonoylethanolamine, N-oleoylethanolamine, N-palmitoylethanolamine and 2-arachidonoylglycerol in human cells. 2015 Anal Bioanal Chem pmid:25519724
Walentiny DM et al. Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice. 2015 Neuropharmacology pmid:25698527
Monteleone AM et al. Deranged endocannabinoid responses to hedonic eating in underweight and recently weight-restored patients with anorexia nervosa. 2015 Am. J. Clin. Nutr. pmid:25646322
Gaskari SA et al. Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids. 2015 J. Hepatol. pmid:25640062
Juan CC et al. Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome. 2015 Fertil. Steril. pmid:25935491
Vázquez C et al. Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies. 2015 Neurobiol. Dis. pmid:25917763
Jokisch V et al. Endocannabinoid Levels in Newborns in Relation to the Mode of Delivery. 2015 Am J Perinatol pmid:25915139
Manduca A et al. Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. 2015 Eur Neuropsychopharmacol pmid:25914159
Llorente-Berzal A et al. 2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons. 2015 Psychopharmacology (Berl.) pmid:25814137
Pisanti S et al. Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. 2015 J. Cell. Physiol. pmid:25684344
Aliczki M et al. Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. 2015 Psychopharmacology (Berl.) pmid:25547462
Urquhart P et al. Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases. 2015 Biochim. Biophys. Acta pmid:25543004
Park SW et al. Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species. 2015 Head Neck pmid:24797795
Wollank Y et al. Inhibition of FAAH confers increased stem cell migration via PPARα. 2015 J. Lipid Res. pmid:26263913
Checa A et al. Lipid mediator profile in vernix caseosa reflects skin barrier development. 2015 Sci Rep pmid:26521946
Jalin AM et al. Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity. 2015 PLoS ONE pmid:26517721
Morena M et al. Training-Associated Emotional Arousal Shapes Endocannabinoid Modulation of Spatial Memory Retrieval in Rats. 2015 J. Neurosci. pmid:26468197
Zheng G et al. Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways. 2015 Exp. Neurol. pmid:26408049
Szafran B et al. Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate inflammation. 2015 Prostaglandins Other Lipid Mediat. pmid:26403860
Mitchener MM et al. Competition and allostery govern substrate selectivity of cyclooxygenase-2. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26392530
Wang H et al. Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. 2015 Cell Rep pmid:26365195
Ho WS et al. Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol. 2015 Br. J. Pharmacol. pmid:26294342
DiPatrizio NV et al. Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. 2015 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:26290104
La Porta C et al. Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain. 2015 Pain pmid:26067584
Hutch CR et al. An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction. 2015 Neuroscience pmid:26037800
Dotsey EY et al. Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. 2015 Chem. Biol. pmid:26000748
Chicca A et al. 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. 2015 J Neuroinflammation pmid:25962384
Liu Z et al. Involvement of GluR2 up-regulation in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptor in mice. 2015 Sci Rep pmid:25830356
Thieme U et al. Quantification of anandamide and 2-arachidonoylglycerol plasma levels to examine potential influences of tetrahydrocannabinol application on the endocannabinoid system in humans. 2014 Jan-Feb Drug Test Anal pmid:24424856
den Boon FS et al. Endocannabinoids produced upon action potential firing evoke a Cl(-) current via type-2 cannabinoid receptors in the medial prefrontal cortex. 2014 Pflugers Arch. pmid:24671573
Shonesy BC et al. Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. 2014 Cell Rep pmid:25466252
Gasperi V et al. 2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts. 2014 Cell Cycle pmid:25427281
Zhang J et al. Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease. 2014 J. Neurosci. pmid:25378159
Fezza F et al. Endocannabinoids, related compounds and their metabolic routes. 2014 Molecules pmid:25347455
Smaga I et al. Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures. 2014 Neurotox Res pmid:24652522
Kohnz RA and Nomura DK Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids. 2014 Chem Soc Rev pmid:24676249
Pastor A et al. Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. 2014 J. Lipid Res. pmid:24610889
Stanley CP and O'Sullivan SE Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries. 2014 Pharmacol. Res. pmid:24548820
Pérez-Morales M et al. 2-Arachidonoylglycerol into the lateral hypothalamus improves reduced sleep in adult rats subjected to maternal separation. 2014 Neuroreport pmid:25356522
Signorello MG and Leoncini G Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway. 2014 Biochimie pmid:25068972
Fernández-Suárez D et al. Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. 2014 Neurobiol. Aging pmid:24973119
Petrenko AB et al. Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. 2014 Behav. Brain Res. pmid:24906199
Tsurumura T and Tsuge H Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure. 2014 J. Struct. Funct. Genomics pmid:24894647
Pascual AC et al. Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging. 2014 Exp. Gerontol. pmid:24768821
Gasperi V et al. 2-Arachidonoylglycerol modulates human endothelial cell/leukocyte interactions by controlling selectin expression through CB1 and CB2 receptors. 2014 Int. J. Biochem. Cell Biol. pmid:24721209
Alhouayek M et al. Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy. 2014 Drug Discov. Today pmid:23891880
Morena M et al. Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25489086
Khasabova IA et al. JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. 2014 Pharmacol. Res. pmid:25304184
McDougle DR et al. Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. 2014 J. Pharmacol. Exp. Ther. pmid:25277139
Özdemir B et al. Endocannabinoids and inflammatory response in periodontal ligament cells. 2014 PLoS ONE pmid:25226300
Navarria A et al. The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. 2014 Pharmacol. Res. pmid:24861565
Nader J et al. Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. 2014 Neuropharmacology pmid:24709540
Sun LJ et al. Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication. 2014 Int. J. Infect. Dis. pmid:24704332
Basavarajappa BS et al. Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice. 2014 Hippocampus pmid:24648181
Oleson EB et al. Cannabinoid receptor activation shifts temporally engendered patterns of dopamine release. 2014 Neuropsychopharmacology pmid:24345819
Aaltonen N et al. Brain regional cannabinoid CB(1) receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice. 2014 Eur J Pharm Sci pmid:24012970
Brantl SA et al. Activation of platelets by the endocannabinoids 2-arachidonoylglycerol and virodhamine is mediated by their conversion to arachidonic acid and thromboxane A2, not by activation of cannabinoid receptors. 2014 Platelets pmid:24102401
Brantl SA et al. Mechanism of platelet activation induced by endocannabinoids in blood and plasma. 2014 Platelets pmid:23789792
Iannotti FA et al. The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24927567
Tiburu EK and Shen L Distance measurements and conformational analysis of sn-2-arachidonoylglycerol-membrane sample by ²H-³¹P REDOR NMR. 2014 J. Membr. Biol. pmid:24402242
Costa MA et al. 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. 2014 Reproduction pmid:24324206
Laitinen T et al. Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. 2014 Mol. Pharmacol. pmid:24368842
Koltyn KF et al. Mechanisms of exercise-induced hypoalgesia. 2014 J Pain pmid:25261342
Alvheim AR et al. Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet. 2014 Lipids pmid:24081493
Pertwee RG Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications. 2014 Proc Nutr Soc pmid:24135210
Burston JJ and Woodhams SG Endocannabinoid system and pain: an introduction. 2014 Proc Nutr Soc pmid:24148358
Desroches J et al. Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB₁ and CB₂ receptors. 2014 Neuropharmacology pmid:24148808
Yang K et al. Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. 2014 Hippocampus pmid:25087967
Fezza F et al. Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. 2014 Mol. Cell. Neurosci. pmid:25064144
Jergas B et al. O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus. 2014 Naunyn Schmiedebergs Arch. Pharmacol. pmid:24853577
Pava MJ et al. Endocannabinoid modulation of cortical up-states and NREM sleep. 2014 PLoS ONE pmid:24520411
Sanson B et al. Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. 2014 Acta Crystallogr. D Biol. Crystallogr. pmid:24531463
Ohno-Shosaku T and Kano M Endocannabinoid-mediated retrograde modulation of synaptic transmission. 2014 Curr. Opin. Neurobiol. pmid:24747340
Limebeer CL et al. Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system. 2014 Psychopharmacology (Berl.) pmid:24043345
Kim J and Watkins BA Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity. 2014 J. Nutr. Biochem. pmid:24854955
Manna JD et al. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. 2014 J. Biol. Chem. pmid:25301951