2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Epilepsy D004827 35 associated lipids
Nerve Degeneration D009410 53 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Morphine Dependence D009021 9 associated lipids
Catalepsy D002375 30 associated lipids
Hyperkinesis D006948 11 associated lipids
Hyperinsulinism D006946 27 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Hypothermia D007035 19 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Head Injuries, Closed D016489 5 associated lipids
Brain Concussion D001924 5 associated lipids
Encephalitis D004660 15 associated lipids
Memory Disorders D008569 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2-arachidonoylglycerol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
den Boon FS et al. Endocannabinoids produced upon action potential firing evoke a Cl(-) current via type-2 cannabinoid receptors in the medial prefrontal cortex. 2014 Pflugers Arch. pmid:24671573
Fezza F et al. Endocannabinoids, related compounds and their metabolic routes. 2014 Molecules pmid:25347455
Flores-Otero J et al. Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. 2014 Nat Commun pmid:25081814
Petrenko AB et al. Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. 2014 Behav. Brain Res. pmid:24906199
Tsurumura T and Tsuge H Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure. 2014 J. Struct. Funct. Genomics pmid:24894647
Pascual AC et al. Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging. 2014 Exp. Gerontol. pmid:24768821
Gasperi V et al. 2-Arachidonoylglycerol modulates human endothelial cell/leukocyte interactions by controlling selectin expression through CB1 and CB2 receptors. 2014 Int. J. Biochem. Cell Biol. pmid:24721209
Lu Y et al. Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against LPS-induced impairments in rat caudate nucleus. 2014 J. Mol. Neurosci. pmid:24510751
Khasabova IA et al. JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. 2014 Pharmacol. Res. pmid:25304184
McDougle DR et al. Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. 2014 J. Pharmacol. Exp. Ther. pmid:25277139
Özdemir B et al. Endocannabinoids and inflammatory response in periodontal ligament cells. 2014 PLoS ONE pmid:25226300
Navarria A et al. The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. 2014 Pharmacol. Res. pmid:24861565
Oleson EB et al. Cannabinoid receptor activation shifts temporally engendered patterns of dopamine release. 2014 Neuropsychopharmacology pmid:24345819
Larose MC et al. Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol. 2014 J. Allergy Clin. Immunol. pmid:24530098
Abdulnour J et al. Circulating endocannabinoids in insulin sensitive vs. insulin resistant obese postmenopausal women. A MONET group study. 2014 Obesity (Silver Spring) pmid:23616305
Brantl SA et al. Mechanism of platelet activation induced by endocannabinoids in blood and plasma. 2014 Platelets pmid:23789792
Laitinen T et al. Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. 2014 Mol. Pharmacol. pmid:24368842
Koltyn KF et al. Mechanisms of exercise-induced hypoalgesia. 2014 J Pain pmid:25261342
Alvheim AR et al. Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet. 2014 Lipids pmid:24081493
Jergas B et al. O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus. 2014 Naunyn Schmiedebergs Arch. Pharmacol. pmid:24853577
Ohno-Shosaku T and Kano M Endocannabinoid-mediated retrograde modulation of synaptic transmission. 2014 Curr. Opin. Neurobiol. pmid:24747340
Chianese R et al. Hypothalamus-pituitary axis: an obligatory target for endocannabinoids to inhibit steroidogenesis in frog testis. 2014 Gen. Comp. Endocrinol. pmid:24566122
Kim J and Watkins BA Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity. 2014 J. Nutr. Biochem. pmid:24854955
Manna JD et al. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. 2014 J. Biol. Chem. pmid:25301951
Pascual AC et al. Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. 2013 Mar-Apr Biofactors pmid:23281018
Fonseca BM et al. Endogenous cannabinoids revisited: a biochemistry perspective. 2013 Apr-May Prostaglandins Other Lipid Mediat. pmid:23474290
Fagundo AB et al. Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. 2013 PLoS ONE pmid:23840456
Baggelaar MP et al. Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain. 2013 Angew. Chem. Int. Ed. Engl. pmid:24173880
Sergi M et al. Determination of the two major endocannabinoids in human plasma by μ-SPE followed by HPLC-MS/MS. 2013 Anal Bioanal Chem pmid:22847477
Ueda N et al. Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways. 2013 FEBS J. pmid:23425575
Sugaya Y et al. The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus. 2013 J. Neurosci. pmid:23426686
DiPatrizio NV et al. Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. 2013 FASEB J. pmid:23463697
Yuan S and Burrell BD Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation. 2013 J. Neurosci. pmid:23467351
Kinsey SG et al. Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects. 2013 J. Pharmacol. Exp. Ther. pmid:23412396
Rea K et al. Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats. 2013 Pain pmid:23414578
Shonesy BC et al. CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling. 2013 Nat. Neurosci. pmid:23502535
Siegmund SV et al. Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. 2013 Biochem. Biophys. Res. Commun. pmid:23806692
Keimpema E et al. Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling. 2013 Sci Rep pmid:23806960
Pérez-Morales M et al. 2-AG into the lateral hypothalamus increases REM sleep and cFos expression in melanin concentrating hormone neurons in rats. 2013 Pharmacol. Biochem. Behav. pmid:23603032
Chiou LC et al. Targeting the cannabinoid system for pain relief? 2013 Acta Anaesthesiol Taiwan pmid:24529672
Cristino L et al. Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23630288
Barricklow J and Blatnik M 2-Arachidonoylglycerol is a substrate for butyrylcholinesterase: A potential mechanism for extracellular endocannabinoid regulation. 2013 Arch. Biochem. Biophys. pmid:23689009
Bari M et al. In vitro and in vivo models of Huntington's disease show alterations in the endocannabinoid system. 2013 FEBS J. pmid:23659592
Chouinard F et al. 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV. 2013 J. Leukoc. Biol. pmid:23242611
Rivera P et al. Cocaine self-administration differentially modulates the expression of endogenous cannabinoid system-related proteins in the hippocampus of Lewis vs. Fischer 344 rats. 2013 Int. J. Neuropsychopharmacol. pmid:23217608
Valdeolivas S et al. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. 2013 Cell Death Dis pmid:24136226
Jäntti MH et al. Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling. 2013 Mol. Pharmacol. pmid:23233488
Su LD et al. Retrograde cPLA2α/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation. 2013 Cerebellum pmid:23307660
Keimpema E et al. Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23319656
Shimizu T et al. Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats. 2013 J. Pharmacol. Sci. pmid:23386378
Tchantchou F and Zhang Y Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. 2013 J. Neurotrauma pmid:23151067
Alhouayek M et al. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24101490
Iannotti FA et al. Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23830028
Neumeister A et al. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. 2013 Mol. Psychiatry pmid:23670490
Jain T et al. Diacylglycerol lipaseα (DAGLα) and DAGLβ cooperatively regulate the production of 2-arachidonoyl glycerol in autaptic hippocampal neurons. 2013 Mol. Pharmacol. pmid:23748223
Citraro R et al. Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy. 2013 Neuropharmacology pmid:23206503
Signorello MG et al. The 2-arachidonoylglycerol effect on myosin light chain phosphorylation in human platelets. 2013 Biochimie pmid:23702422
Higgins A et al. Differential modulation of nociceptive versus non-nociceptive synapses by endocannabinoids. 2013 Mol Pain pmid:23725095
Almeida-Santos AF et al. Modulation of anxiety-like behavior by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray. 2013 Behav. Brain Res. pmid:23714073
Perez-Rosello T et al. Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis. 2013 J. Neurosci. pmid:23719795
Yang Y et al. Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. 2013 Cell. Signal. pmid:23142606
Sticht MA et al. 2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus. 2013 Physiol. Behav. pmid:23958470
Chanda D et al. Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH. 2013 PLoS ONE pmid:23894352
Pellkofer HL et al. The major brain endocannabinoid 2-AG controls neuropathic pain and mechanical hyperalgesia in patients with neuromyelitis optica. 2013 PLoS ONE pmid:23951176
Costola-de-Souza C et al. Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice. 2013 PLoS ONE pmid:24204926
Du H et al. Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG. 2013 J. Neurosci. pmid:24048832
Guindon J et al. Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. 2013 Pharmacol. Res. pmid:23127915
Hashimotodani Y et al. Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: evidence for on-demand biosynthesis of 2-arachidonoylglycerol. 2013 J. Physiol. (Lond.) pmid:23858009
Kerr DM et al. The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. 2013 Br. J. Pharmacol. pmid:23043675
Han B et al. Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor. 2013 Anal. Biochem. pmid:23044255
Lindgren CA et al. Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction. 2013 J. Physiol. (Lond.) pmid:23818695
Frazier CJ Preformed vs. on-demand: molecular economics of endocannabinoid signalling. 2013 J. Physiol. (Lond.) pmid:24085490
Starowicz K et al. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. 2013 PLoS ONE pmid:23573230
Subbanna S et al. Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficits. 2013 J. Neurosci. pmid:23575834
Descalzi F et al. Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. 2013 Tissue Eng Part A pmid:23578218
Morgan CJ et al. Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms. 2013 Br J Psychiatry pmid:23580381
Bisogno T et al. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. 2013 Br. J. Pharmacol. pmid:23072382
Blankman JL and Cravatt BF Chemical probes of endocannabinoid metabolism. 2013 Pharmacol. Rev. pmid:23512546
Berge K et al. Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men. 2013 Lipids Health Dis pmid:23706001
Zygmunt PM et al. Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. 2013 PLoS ONE pmid:24312564
Carr RL et al. Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure. 2013 Toxicol. Sci. pmid:23761300
Wang R et al. Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme. 2013 Biochemistry pmid:24083319
Ikeda H et al. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. 2013 Neuroscience pmid:23892011
Yuan S and Burrell BD Nonnociceptive afferent activity depresses nocifensive behavior and nociceptive synapses via an endocannabinoid-dependent mechanism. 2013 J. Neurophysiol. pmid:24027102
Ilayan E et al. Do cannabinoids exhibit a tyramine-like effect? 2013 Naunyn Schmiedebergs Arch. Pharmacol. pmid:23900610
Krumbholz A et al. Diagnostic value of concentration profiles of glucocorticosteroids and endocannabinoids in hair. 2013 Ther Drug Monit pmid:23942543
Hill MN et al. Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. 2013 Psychoneuroendocrinology pmid:24035186
Blasio A et al. Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala. 2013 Neuropsychopharmacology pmid:23793355
Bernabò N et al. Systems biology analysis of the endocannabinoid system reveals a scale-free network with distinct roles for anandamide and 2-arachidonoylglycerol. 2013 OMICS pmid:24117401
Gesell FK et al. Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. 2013 BMC Vet. Res. pmid:24370333
Shinjyo N et al. Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. 2013 J. Neurosci. Res. pmid:23633391
Malenczyk K et al. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. 2013 J. Biol. Chem. pmid:24089517
Brocato B et al. Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. 2013 Placenta pmid:24008071
Baur R et al. Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors. 2013 J. Neurochem. pmid:23600744
Feuerecker M et al. Effect of an acute consumption of a moderate amount of ethanol on plasma endocannabinoid levels in humans. 2012 May-Jun Alcohol Alcohol. pmid:22278319
Xu JY et al. Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids. 2012 J. Physiol. (Lond.) pmid:22411015
Petrovszki Z et al. The effects of peptide and lipid endocannabinoids on arthritic pain at the spinal level. 2012 Anesth. Analg. pmid:22451592
Tsumura M et al. TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. 2012 Cell Calcium pmid:22656960
Chanda D et al. Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene. 2012 J. Biol. Chem. pmid:22989885
Strewe C et al. Effects of parabolic flight and spaceflight on the endocannabinoid system in humans. 2012 Rev Neurosci pmid:23023882