Baggelaar MP et al. |
Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain. |
2013 |
Angew. Chem. Int. Ed. Engl. |
pmid:24173880
|
Rea K et al. |
Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats. |
2013 |
Pain |
pmid:23414578
|
Shonesy BC et al. |
CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling. |
2013 |
Nat. Neurosci. |
pmid:23502535
|
Siegmund SV et al. |
Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:23806692
|
Keimpema E et al. |
Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling. |
2013 |
Sci Rep |
pmid:23806960
|
Pérez-Morales M et al. |
2-AG into the lateral hypothalamus increases REM sleep and cFos expression in melanin concentrating hormone neurons in rats. |
2013 |
Pharmacol. Biochem. Behav. |
pmid:23603032
|
Cristino L et al. |
Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons. |
2013 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:23630288
|
Barricklow J and Blatnik M |
2-Arachidonoylglycerol is a substrate for butyrylcholinesterase: A potential mechanism for extracellular endocannabinoid regulation. |
2013 |
Arch. Biochem. Biophys. |
pmid:23689009
|
Bari M et al. |
In vitro and in vivo models of Huntington's disease show alterations in the endocannabinoid system. |
2013 |
FEBS J. |
pmid:23659592
|
Chouinard F et al. |
2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV. |
2013 |
J. Leukoc. Biol. |
pmid:23242611
|
Rivera P et al. |
Cocaine self-administration differentially modulates the expression of endogenous cannabinoid system-related proteins in the hippocampus of Lewis vs. Fischer 344 rats. |
2013 |
Int. J. Neuropsychopharmacol. |
pmid:23217608
|
Jäntti MH et al. |
Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling. |
2013 |
Mol. Pharmacol. |
pmid:23233488
|
Su LD et al. |
Retrograde cPLA2α/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation. |
2013 |
Cerebellum |
pmid:23307660
|
Jain T et al. |
Diacylglycerol lipaseα (DAGLα) and DAGLβ cooperatively regulate the production of 2-arachidonoyl glycerol in autaptic hippocampal neurons. |
2013 |
Mol. Pharmacol. |
pmid:23748223
|
Signorello MG et al. |
The 2-arachidonoylglycerol effect on myosin light chain phosphorylation in human platelets. |
2013 |
Biochimie |
pmid:23702422
|
Higgins A et al. |
Differential modulation of nociceptive versus non-nociceptive synapses by endocannabinoids. |
2013 |
Mol Pain |
pmid:23725095
|
Almeida-Santos AF et al. |
Modulation of anxiety-like behavior by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray. |
2013 |
Behav. Brain Res. |
pmid:23714073
|
Perez-Rosello T et al. |
Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis. |
2013 |
J. Neurosci. |
pmid:23719795
|
Yang Y et al. |
Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. |
2013 |
Cell. Signal. |
pmid:23142606
|
Sticht MA et al. |
2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus. |
2013 |
Physiol. Behav. |
pmid:23958470
|
Chanda D et al. |
Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH. |
2013 |
PLoS ONE |
pmid:23894352
|
Pellkofer HL et al. |
The major brain endocannabinoid 2-AG controls neuropathic pain and mechanical hyperalgesia in patients with neuromyelitis optica. |
2013 |
PLoS ONE |
pmid:23951176
|
Costola-de-Souza C et al. |
Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice. |
2013 |
PLoS ONE |
pmid:24204926
|
Du H et al. |
Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG. |
2013 |
J. Neurosci. |
pmid:24048832
|
Guindon J et al. |
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. |
2013 |
Pharmacol. Res. |
pmid:23127915
|
Han B et al. |
Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor. |
2013 |
Anal. Biochem. |
pmid:23044255
|
Starowicz K et al. |
Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. |
2013 |
PLoS ONE |
pmid:23573230
|
Subbanna S et al. |
Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficits. |
2013 |
J. Neurosci. |
pmid:23575834
|
Morgan CJ et al. |
Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms. |
2013 |
Br J Psychiatry |
pmid:23580381
|
Blankman JL and Cravatt BF |
Chemical probes of endocannabinoid metabolism. |
2013 |
Pharmacol. Rev. |
pmid:23512546
|
Carr RL et al. |
Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure. |
2013 |
Toxicol. Sci. |
pmid:23761300
|
Yuan S and Burrell BD |
Nonnociceptive afferent activity depresses nocifensive behavior and nociceptive synapses via an endocannabinoid-dependent mechanism. |
2013 |
J. Neurophysiol. |
pmid:24027102
|
Blasio A et al. |
Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala. |
2013 |
Neuropsychopharmacology |
pmid:23793355
|
Baur R et al. |
Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors. |
2013 |
J. Neurochem. |
pmid:23600744
|
Fonseca BM et al. |
Endogenous cannabinoids revisited: a biochemistry perspective. |
2013 Apr-May |
Prostaglandins Other Lipid Mediat. |
pmid:23474290
|
Pascual AC et al. |
Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. |
2013 Mar-Apr |
Biofactors |
pmid:23281018
|
den Boon FS et al. |
Endocannabinoids produced upon action potential firing evoke a Cl(-) current via type-2 cannabinoid receptors in the medial prefrontal cortex. |
2014 |
Pflugers Arch. |
pmid:24671573
|
Shonesy BC et al. |
Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. |
2014 |
Cell Rep |
pmid:25466252
|
Gasperi V et al. |
2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts. |
2014 |
Cell Cycle |
pmid:25427281
|
Zhang J et al. |
Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease. |
2014 |
J. Neurosci. |
pmid:25378159
|
Fezza F et al. |
Endocannabinoids, related compounds and their metabolic routes. |
2014 |
Molecules |
pmid:25347455
|
Flores-Otero J et al. |
Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. |
2014 |
Nat Commun |
pmid:25081814
|
Nithipatikom K et al. |
A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol. |
2014 |
J. Lipid Res. |
pmid:24958911
|
Karabowicz P et al. |
[Role of endocannabinoid 2-arachidonoylglycerol in the physiology and pathophysiology of the cardiovascular system]. |
2014 |
Postepy Hig Med Dosw (Online) |
pmid:24934539
|
Hillard CJ |
Stress regulates endocannabinoid-CB1 receptor signaling. |
2014 |
Semin. Immunol. |
pmid:24882055
|
Pastor A et al. |
Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. |
2014 |
J. Lipid Res. |
pmid:24610889
|
Stanley CP and O'Sullivan SE |
Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries. |
2014 |
Pharmacol. Res. |
pmid:24548820
|
Signorello MG and Leoncini G |
Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway. |
2014 |
Biochimie |
pmid:25068972
|
Fernández-Suárez D et al. |
Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. |
2014 |
Neurobiol. Aging |
pmid:24973119
|
Petrenko AB et al. |
Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. |
2014 |
Behav. Brain Res. |
pmid:24906199
|
Tsurumura T and Tsuge H |
Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure. |
2014 |
J. Struct. Funct. Genomics |
pmid:24894647
|
Pascual AC et al. |
Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging. |
2014 |
Exp. Gerontol. |
pmid:24768821
|
Gasperi V et al. |
2-Arachidonoylglycerol modulates human endothelial cell/leukocyte interactions by controlling selectin expression through CB1 and CB2 receptors. |
2014 |
Int. J. Biochem. Cell Biol. |
pmid:24721209
|
Lu Y et al. |
Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against LPS-induced impairments in rat caudate nucleus. |
2014 |
J. Mol. Neurosci. |
pmid:24510751
|
Alhouayek M et al. |
Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy. |
2014 |
Drug Discov. Today |
pmid:23891880
|
Khasabova IA et al. |
JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. |
2014 |
Pharmacol. Res. |
pmid:25304184
|
McDougle DR et al. |
Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. |
2014 |
J. Pharmacol. Exp. Ther. |
pmid:25277139
|
Özdemir B et al. |
Endocannabinoids and inflammatory response in periodontal ligament cells. |
2014 |
PLoS ONE |
pmid:25226300
|
Lau BK et al. |
Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. |
2014 |
Br. J. Pharmacol. |
pmid:25041240
|
Laprairie RB et al. |
Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. |
2014 |
J. Biol. Chem. |
pmid:25037227
|
Cipriano M et al. |
The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. |
2014 |
BMC Res Notes |
pmid:25012825
|
Wiley JL et al. |
Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents. |
2014 |
Eur. J. Pharmacol. |
pmid:24858366
|
Navarria A et al. |
The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. |
2014 |
Pharmacol. Res. |
pmid:24861565
|
Nader J et al. |
Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. |
2014 |
Neuropharmacology |
pmid:24709540
|
Sun LJ et al. |
Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication. |
2014 |
Int. J. Infect. Dis. |
pmid:24704332
|
Oleson EB et al. |
Cannabinoid receptor activation shifts temporally engendered patterns of dopamine release. |
2014 |
Neuropsychopharmacology |
pmid:24345819
|
Larose MC et al. |
Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol. |
2014 |
J. Allergy Clin. Immunol. |
pmid:24530098
|
Abdulnour J et al. |
Circulating endocannabinoids in insulin sensitive vs. insulin resistant obese postmenopausal women. A MONET group study. |
2014 |
Obesity (Silver Spring) |
pmid:23616305
|
Aaltonen N et al. |
Brain regional cannabinoid CB(1) receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice. |
2014 |
Eur J Pharm Sci |
pmid:24012970
|
Brantl SA et al. |
Activation of platelets by the endocannabinoids 2-arachidonoylglycerol and virodhamine is mediated by their conversion to arachidonic acid and thromboxane A2, not by activation of cannabinoid receptors. |
2014 |
Platelets |
pmid:24102401
|
Brantl SA et al. |
Mechanism of platelet activation induced by endocannabinoids in blood and plasma. |
2014 |
Platelets |
pmid:23789792
|
Iannotti FA et al. |
The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. |
2014 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:24927567
|
Tiburu EK and Shen L |
Distance measurements and conformational analysis of sn-2-arachidonoylglycerol-membrane sample by ²H-³¹P REDOR NMR. |
2014 |
J. Membr. Biol. |
pmid:24402242
|
Costa MA et al. |
2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. |
2014 |
Reproduction |
pmid:24324206
|
Laitinen T et al. |
Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. |
2014 |
Mol. Pharmacol. |
pmid:24368842
|
Koltyn KF et al. |
Mechanisms of exercise-induced hypoalgesia. |
2014 |
J Pain |
pmid:25261342
|
Melis M et al. |
Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. |
2014 |
J. Neurosci. |
pmid:25232109
|
Murataeva N et al. |
Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS. |
2014 |
Br. J. Pharmacol. |
pmid:24102242
|
Yasuo S et al. |
2-Arachidonoyl glycerol sensitizes the pars distalis and enhances forskolin-stimulated prolactin secretion in Syrian hamsters. |
2014 |
Chronobiol. Int. |
pmid:24200164
|
Alvheim AR et al. |
Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet. |
2014 |
Lipids |
pmid:24081493
|
Desroches J et al. |
Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CBâ‚ and CBâ‚‚ receptors. |
2014 |
Neuropharmacology |
pmid:24148808
|
Yang K et al. |
Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. |
2014 |
Hippocampus |
pmid:25087967
|
Fezza F et al. |
Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. |
2014 |
Mol. Cell. Neurosci. |
pmid:25064144
|
Pulgar VM et al. |
Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. |
2014 |
Hypertension |
pmid:24935942
|
Jergas B et al. |
O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus. |
2014 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:24853577
|
Pava MJ et al. |
Endocannabinoid modulation of cortical up-states and NREM sleep. |
2014 |
PLoS ONE |
pmid:24520411
|
Sanson B et al. |
Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. |
2014 |
Acta Crystallogr. D Biol. Crystallogr. |
pmid:24531463
|
Ohno-Shosaku T and Kano M |
Endocannabinoid-mediated retrograde modulation of synaptic transmission. |
2014 |
Curr. Opin. Neurobiol. |
pmid:24747340
|
Fowler CJ |
Has FLAT fallen flat? |
2014 |
Trends Pharmacol. Sci. |
pmid:24398120
|
Chianese R et al. |
Hypothalamus-pituitary axis: an obligatory target for endocannabinoids to inhibit steroidogenesis in frog testis. |
2014 |
Gen. Comp. Endocrinol. |
pmid:24566122
|
Rea K et al. |
Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state. |
2014 |
Eur. J. Neurosci. |
pmid:24494683
|
Zheng Y et al. |
Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system. |
2014 |
Eur. J. Pharmacol. |
pmid:24508383
|
Krishnan G and Chatterjee N |
Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity. |
2014 |
Mol. Cell. Neurosci. |
pmid:24418364
|
Nicolussi S et al. |
Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice. |
2014 |
Pharmacol. Res. |
pmid:24412246
|
Bystrowska B et al. |
Changes in endocannabinoid and N-acylethanolamine levels in rat brain structures following cocaine self-administration and extinction training. |
2014 |
Prog. Neuropsychopharmacol. Biol. Psychiatry |
pmid:24334211
|
Schaefer C et al. |
Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders. |
2014 |
Eur Arch Psychiatry Clin Neurosci |
pmid:24253425
|
Limebeer CL et al. |
Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system. |
2014 |
Psychopharmacology (Berl.) |
pmid:24043345
|
Kim J and Watkins BA |
Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity. |
2014 |
J. Nutr. Biochem. |
pmid:24854955
|
Alpár A et al. |
Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. |
2014 |
Nat Commun |
pmid:25030704
|
Manna JD et al. |
Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. |
2014 |
J. Biol. Chem. |
pmid:25301951
|