| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Baggelaar MP et al. | Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:24173880 |
| Sergi M et al. | Determination of the two major endocannabinoids in human plasma by μ-SPE followed by HPLC-MS/MS. | 2013 | Anal Bioanal Chem | pmid:22847477 |
| Ueda N et al. | Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways. | 2013 | FEBS J. | pmid:23425575 |
| Sugaya Y et al. | The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus. | 2013 | J. Neurosci. | pmid:23426686 |
| DiPatrizio NV et al. | Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. | 2013 | FASEB J. | pmid:23463697 |
| Yuan S and Burrell BD | Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation. | 2013 | J. Neurosci. | pmid:23467351 |
| Kinsey SG et al. | Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23412396 |
| Chiou LC et al. | Targeting the cannabinoid system for pain relief? | 2013 | Acta Anaesthesiol Taiwan | pmid:24529672 |
| Valdeolivas S et al. | The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. | 2013 | Cell Death Dis | pmid:24136226 |
| Su LD et al. | Retrograde cPLA2α/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation. | 2013 | Cerebellum | pmid:23307660 |
| Alhouayek M et al. | Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24101490 |
| Iannotti FA et al. | Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23830028 |
| Citraro R et al. | Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy. | 2013 | Neuropharmacology | pmid:23206503 |
| Perez-Rosello T et al. | Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis. | 2013 | J. Neurosci. | pmid:23719795 |
| Yang Y et al. | Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. | 2013 | Cell. Signal. | pmid:23142606 |
| Sticht MA et al. | 2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus. | 2013 | Physiol. Behav. | pmid:23958470 |
| Chanda D et al. | Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH. | 2013 | PLoS ONE | pmid:23894352 |
| Pellkofer HL et al. | The major brain endocannabinoid 2-AG controls neuropathic pain and mechanical hyperalgesia in patients with neuromyelitis optica. | 2013 | PLoS ONE | pmid:23951176 |
| Costola-de-Souza C et al. | Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice. | 2013 | PLoS ONE | pmid:24204926 |
| Du H et al. | Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG. | 2013 | J. Neurosci. | pmid:24048832 |
| Hashimotodani Y et al. | Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: evidence for on-demand biosynthesis of 2-arachidonoylglycerol. | 2013 | J. Physiol. (Lond.) | pmid:23858009 |
| Kerr DM et al. | The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. | 2013 | Br. J. Pharmacol. | pmid:23043675 |
| Han B et al. | Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor. | 2013 | Anal. Biochem. | pmid:23044255 |
| Lindgren CA et al. | Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction. | 2013 | J. Physiol. (Lond.) | pmid:23818695 |
| Frazier CJ | Preformed vs. on-demand: molecular economics of endocannabinoid signalling. | 2013 | J. Physiol. (Lond.) | pmid:24085490 |
| Descalzi F et al. | Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. | 2013 | Tissue Eng Part A | pmid:23578218 |
| Bisogno T et al. | A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. | 2013 | Br. J. Pharmacol. | pmid:23072382 |
| Carr RL et al. | Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure. | 2013 | Toxicol. Sci. | pmid:23761300 |
| Ilayan E et al. | Do cannabinoids exhibit a tyramine-like effect? | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23900610 |
| Krumbholz A et al. | Diagnostic value of concentration profiles of glucocorticosteroids and endocannabinoids in hair. | 2013 | Ther Drug Monit | pmid:23942543 |
| Bernabò N et al. | Systems biology analysis of the endocannabinoid system reveals a scale-free network with distinct roles for anandamide and 2-arachidonoylglycerol. | 2013 | OMICS | pmid:24117401 |
| Gesell FK et al. | Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. | 2013 | BMC Vet. Res. | pmid:24370333 |
| Shinjyo N et al. | Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. | 2013 | J. Neurosci. Res. | pmid:23633391 |
| Malenczyk K et al. | CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. | 2013 | J. Biol. Chem. | pmid:24089517 |
| Fonseca BM et al. | Endogenous cannabinoids revisited: a biochemistry perspective. | 2013 Apr-May | Prostaglandins Other Lipid Mediat. | pmid:23474290 |
| Pascual AC et al. | Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. | 2013 Mar-Apr | Biofactors | pmid:23281018 |
| den Boon FS et al. | Endocannabinoids produced upon action potential firing evoke a Cl(-) current via type-2 cannabinoid receptors in the medial prefrontal cortex. | 2014 | Pflugers Arch. | pmid:24671573 |
| Flores-Otero J et al. | Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. | 2014 | Nat Commun | pmid:25081814 |
| Gasperi V et al. | 2-Arachidonoylglycerol modulates human endothelial cell/leukocyte interactions by controlling selectin expression through CB1 and CB2 receptors. | 2014 | Int. J. Biochem. Cell Biol. | pmid:24721209 |
| Lu Y et al. | Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against LPS-induced impairments in rat caudate nucleus. | 2014 | J. Mol. Neurosci. | pmid:24510751 |
| Özdemir B et al. | Endocannabinoids and inflammatory response in periodontal ligament cells. | 2014 | PLoS ONE | pmid:25226300 |
| Lau BK et al. | Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. | 2014 | Br. J. Pharmacol. | pmid:25041240 |
| Larose MC et al. | Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol. | 2014 | J. Allergy Clin. Immunol. | pmid:24530098 |
| Abdulnour J et al. | Circulating endocannabinoids in insulin sensitive vs. insulin resistant obese postmenopausal women. A MONET group study. | 2014 | Obesity (Silver Spring) | pmid:23616305 |
| Laitinen T et al. | Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. | 2014 | Mol. Pharmacol. | pmid:24368842 |
| Melis M et al. | Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. | 2014 | J. Neurosci. | pmid:25232109 |
| Murataeva N et al. | Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS. | 2014 | Br. J. Pharmacol. | pmid:24102242 |
| Ohno-Shosaku T and Kano M | Endocannabinoid-mediated retrograde modulation of synaptic transmission. | 2014 | Curr. Opin. Neurobiol. | pmid:24747340 |
| Chianese R et al. | Hypothalamus-pituitary axis: an obligatory target for endocannabinoids to inhibit steroidogenesis in frog testis. | 2014 | Gen. Comp. Endocrinol. | pmid:24566122 |
| Zheng Y et al. | Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system. | 2014 | Eur. J. Pharmacol. | pmid:24508383 |