MeSH term | MeSH ID | Detail |
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Body Weight | D001835 | 333 associated lipids |
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Karwad MA et al. | The role of CB in intestinal permeability and inflammation. | 2017 | FASEB J. | pmid:28404744 |
Bedse G et al. | Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety. | 2017 | Biol. Psychiatry | pmid:28438413 |
Almeida-Santos AF et al. | 2-Arachidonoylglycerol endocannabinoid signaling coupled to metabotropic glutamate receptor type-5 modulates anxiety-like behavior in the rat ventromedial prefrontal cortex. | 2017 | J. Psychopharmacol. (Oxford) | pmid:28440729 |
Fanelli F et al. | Plasma 2-arachidonoylglycerol is a biomarker of age and menopause related insulin resistance and dyslipidemia in lean but not in obese men and women. | 2017 | Mol Metab | pmid:28462075 |
Becker TM et al. | Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese mice. | 2017 | Mol Metab | pmid:28580289 |
Chicca A et al. | Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28584105 |
Francou MM et al. | Human sperm motility, capacitation and acrosome reaction are impaired by 2-arachidonoylglycerol endocannabinoid. | 2017 | Histol. Histopathol. | pmid:28585678 |
Deng H and van der Stelt M | Chemical tools to modulate 2-arachidonoylglycerol biosynthesis. | 2018 | Biotechnol. Appl. Biochem. | pmid:28589628 |
Avraham Y et al. | 2-Arachidonoylglycerol as a possible treatment for anorexia nervosa in animal model in mice. | 2017 | Brain Res. | pmid:28606779 |
Signorello MG and Leoncini G | Activation of CaMKKβ/AMPKα pathway by 2-AG in human platelets. | 2018 | J. Cell. Biochem. | pmid:28661046 |