2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Acute Pain D059787 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


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What lipids are associated with 2-arachidonoylglycerol?

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What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
Battista N et al. The role of endocannabinoids in gonadal function and fertility along the evolutionary axis. 2012 Mol. Cell. Endocrinol. pmid:22305972
Fanelli F et al. Estimation of reference intervals of five endocannabinoids and endocannabinoid related compounds in human plasma by two dimensional-LC/MS/MS. 2012 J. Lipid Res. pmid:22172516
Roberts CJ et al. Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol. 2012 Neuroscience pmid:22192839
Giordano C et al. TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception. 2012 Cereb. Cortex pmid:22139792
Higuchi S et al. Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. 2012 PLoS ONE pmid:22737214
Alhouayek M and Muccioli GG The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. 2012 Trends Mol Med pmid:22917662
Li C et al. Expression and function of monoacylglycerol lipase in mouse β-cells and human islets of Langerhans. 2012 Cell. Physiol. Biochem. pmid:22739267
Matuszak N et al. Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth. 2012 Eur J Pharm Sci pmid:22127371
Carloni S et al. Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. 2012 Pediatr. Res. pmid:22821058
Nithipatikom K et al. Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells. 2012 Endocrinology pmid:22087025
Gregg LC et al. Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. 2012 J. Neurosci. pmid:22787031
Deshmukh RR and Sharma PL Stimulation of accumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats. 2012 Pharmacol. Res. pmid:22728691
Clemente JC et al. Screening and characterization of human monoglyceride lipase active site inhibitors using orthogonal binding and functional assays. 2012 J Biomol Screen pmid:22496098
Czifra G et al. Endocannabinoids regulate growth and survival of human eccrine sweat gland-derived epithelial cells. 2012 J. Invest. Dermatol. pmid:22513781
Caprioli A et al. The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models. 2012 J. Pharmacol. Exp. Ther. pmid:22514334
Dubreucq S et al. Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. 2012 Neuropsychopharmacology pmid:22434220
Pucci M et al. Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. 2012 J. Biol. Chem. pmid:22431736
McLaughlin RJ et al. Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. 2012 Eur Neuropsychopharmacol pmid:22325231
Kallendrusch S et al. Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage. 2012 PLoS ONE pmid:23284665
Jones BR et al. Surrogate matrix and surrogate analyte approaches for definitive quantitation of endogenous biomolecules. 2012 Bioanalysis pmid:23088461
Hauer D et al. Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression. 2012 Rev Neurosci pmid:23006898
Gyombolai P et al. Regulation of endocannabinoid release by G proteins: a paracrine mechanism of G protein-coupled receptor action. 2012 Mol. Cell. Endocrinol. pmid:22075205
Song J et al. Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network. 2012 J. Neurosci. pmid:22496555
Psychoyos D et al. Cannabinoid receptor 1 signaling in embryo neurodevelopment. 2012 Birth Defects Res. B Dev. Reprod. Toxicol. pmid:22311661
Katona I and Freund TF Multiple functions of endocannabinoid signaling in the brain. 2012 Annu. Rev. Neurosci. pmid:22524785
Gould GG et al. Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice. 2012 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:22542870
Ueda N et al. Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol. 2011 Jan-Feb Biofactors pmid:21328621
Frazier CJ Key questions of endocannabinoid signalling in the CNS: which, where and when? 2011 J. Physiol. (Lond.) pmid:22001725
Sumislawski JJ et al. Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. 2011 Neuropsychopharmacology pmid:21849983
Zhong P et al. Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. 2011 J. Physiol. (Lond.) pmid:21911610
Marazzi J et al. Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. 2011 J. Immunol. Methods pmid:21920367
Signorello MG et al. Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway. 2011 J. Cell. Biochem. pmid:21608016
Du H et al. Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. 2011 Br. J. Pharmacol. pmid:21501147
Hofmann ME et al. Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. 2011 J. Physiol. (Lond.) pmid:21646412
Sarmad S et al. Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. 2011 J. Neurochem. pmid:21375532
Howlett AC et al. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. 2011 Br. J. Pharmacol. pmid:21545414
Vecchio AJ and Malkowski MG The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. 2011 J. Biol. Chem. pmid:21489986
Balenga NA et al. GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. 2011 Cell Res. pmid:21467997
Chen X et al. Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults. 2011 Neuroscience pmid:21256197
Yoshida T et al. Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21282604
Liao HT et al. Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition. 2011 Br. J. Pharmacol. pmid:21232043
Soderstrom K et al. Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness. 2011 BMC Neurosci pmid:21211022
Petrosino S et al. Alteration of the endocannabinoid system in mouse brain during prion disease. 2011 Neuroscience pmid:21195746
Sciolino NR et al. Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. 2011 Pharmacol. Res. pmid:21600985
Shekhar C Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. 2011 Chem. Biol. pmid:21609833
Ho YC et al. Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition. 2011 J. Neurosci. pmid:21994376
Cippitelli A et al. Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. 2011 PLoS ONE pmid:22140525
Brizzi A et al. Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor. 2011 J. Med. Chem. pmid:22044209
Yoshino H et al. Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. 2011 J. Physiol. (Lond.) pmid:21807615
Khasabova IA et al. Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. 2011 Pharmacol. Res. pmid:21440630